Conocimiento y actitud sobre protección radiológica del personal de salud del Instituto Regional de Enfermedades Neoplásicas Centro - 2023

Objetivo: Establecer la relación entre el conocimiento y la actitud sobre protección radiológica del personal de salud del Instituto Regional de Enfermedades Neoplásicas Centro - 2023. Metodología: Tipo básica, enfoque cuantitativo, nivel correlacional, diseño no experimental y corte transversal, cuya muestra se compuso de 70 integrantes del personal de salud del Instituto Regional de Enfermedades Neoplásicas Centro de los departamentos de diagnóstico por imágenes y radioterapia, mediante muestreo no probabilístico - censal, a quienes se les administraron dos cuestionarios. Resultados: Respecto al nivel de conocimiento, todos los participantes se clasificaron dentro de la categoría “Muy bueno”. Por otra parte, la prueba Rho de Spearman dio un resultado un coeficiente de -,289 y un nivel de significancia de 0.015 entre las variables. Conclusiones: Existe una correlación negativa, débil y estadísticamente significativa entre el conocimiento sobre protección radiológica y la actitud sobre protección radiológica

AERO-MAP: A data compilation and modelling approach to understand spatial variability in fine and coarse mode aerosol composition

Aerosol particles are an important part of the Earth system, but their concentrations are spatially and temporally heterogeneous, as well as variable in size and composition. Particles can interact with incoming solar radiation and outgoing long wave radiation, change cloud properties, affect photochemistry, impact surface air quality, change the surface albedo of snow and ice, and modulate carbon dioxide uptake by the land and ocean. High particulate matter concentrations at the surface represent an important public health hazard. There are substantial datasets describing aerosol particles in the literature or in public health databases, but they have not been compiled for easy use by the climate and air quality modelling community. Here we present a new compilation of PM2.5 and PM10 aerosol observations, focusing on the spatial variability across different observational stations, including composition, and demonstrate a method for comparing the datasets to model output. Overall, most of the planet or even the land fraction does not have sufficient observations of surface concentrations, and especially particle composition to understand the current distribution of particles. Most climate models exclude 10–30 % of the aerosol particles in both PM2.5 and PM10 size fractions across large swaths of the globe in their current configurations, with ammonium nitrate and agricultural dust aerosol being the most important omitted aerosol types

Amma, une étude multidisciplinaire de la mousson ouest-africaine

International audienceLe projet international Amma, d'initiative française, a pour objectif d'améliorer la connaissance et la compréhension de la mousson d'Afrique de l'Ouest et de sa variabilité, de l'échelle journalière à l'échelle interannuelle. Le projet est motivé par la forte variabilité des précipitations associées à ce système de mousson, et par ses conséquences sur la sécurité alimentaire, les ressources en eau et la santé

Subunit Interactions and Requirements for Inhibition of the Yeast V1-ATPase*S⃞

Disassembly of the yeast V-ATPase into cytosolic V1 and membrane V0 sectors inactivates MgATPase activity of the V1-ATPase. This inactivation requires the V1 H subunit (Parra, K. J., Keenan, K. L., and Kane, P. M. (2000) J. Biol. Chem. 275, 21761–21767), but its mechanism is not fully understood. The H subunit has two domains. Interactions of each domain with V1 and V0 subunits were identified by two-hybrid assay. The B subunit of the V1 catalytic headgroup interacted with the H subunit N-terminal domain (H-NT), and the C-terminal domain (H-CT) interacted with V1 subunits B, E (peripheral stalk), and D (central stalk), and the cytosolic N-terminal domain of V0 subunit Vph1p. V1-ATPase complexes from yeast expressing H-NT are partially inhibited, exhibiting 26% the MgATPase activity of complexes with no H subunit. The H-CT domain does not copurify with V1 when expressed in yeast, but the bacterially expressed and purified H-CT domain inhibits MgATPase activity in V1 lacking H almost as well as the full-length H subunit. Binding of full-length H subunit to V1 was more stable than binding of either H-NT or H-CT, suggesting that both domains contribute to binding and inhibition. Intact H and H-CT can bind to the expressed N-terminal domain of Vph1p, but this fragment of Vph1p does not bind to V1 complexes containing subunit H. We propose that upon disassembly, the H subunit undergoes a conformational change that inhibits V1-ATPase activity and precludes V0 interactions