Percepción sobre los usos de suelo en el barrio San Antonio de la ciudad de Cali: entre lo cultural, residencial y comercial

El presente informe es el resultado de un trabajo grado que busca exponer las percepciones de los actores sociales del barrio San Antonio de la ciudad de Santiago de Cali, por los diferentes usos de suelo que se dan entre lo cultural, lo residencial y lo comercial. Para lograr identificar las percepciones, se abordó el tema desde los tres grupos de interés. El primero fue residencial, cuyo objetivo principal de estos actores era que el barrio continuara siendo netamente un lugar para vivir, manteniendo a San Antonio sin establecimientos comerciales, a excepción de tiendas pequeñas. El segundo fue todo lo relacionado con la cultura que caracteriza al barrio, donde el propósito es mantener las tradiciones y poder dar acceso a todo el público por medio del arte, la pintura, las artesanías, el teatro, las actividades musicales, etc., promoviendo de esta forma el turismo en el sector. El tercer grupo de interés son los comerciantes, actores que tienen sus establecimientos tales como: restaurantes, tiendas, fuentes de soda, tertuliaderos, hoteles, hostales, almacenes, oficinas, etc., deseando así la permanencia en la zona, ejerciendo y emprendiendo cada vez más sus actividades comerciales. Este informe se realizó por medio de una investigación cualitativa, se utilizaron instrumentos como: entrevistas, recolección de información en periódicos, revistas, documentación para el marco teórico y análisis del Plan de Ordenamiento Territorial - POT del 2000, creado por la Oficina de Planeación Municipal y la Alcaldía Municipal de Santiago de CaliProyecto de grado (Comunicador Social-Periodista)-- Universidad Autónoma de Occidente, 2014PregradoComunicador(a) Social – Periodist

Packet forwarding for heterogeneous technologies for integrated fronthaul/backhaul

Proceeding of: 2016 European Conference on Networks and Communications (EuCNC)To meet the future mobile user demand at a reduced cost, operators are looking at solutions such as C-RAN and different functional splits to decrease the cost of deploying and maintaining cell sites. The use of these technologies forces operators to manage two physically separated networks, one for backhaul and one for fronthaul. To solve this issue, transport networks for 5G will carry both fronthaul and backhaul traffic operating over heterogeneous data plane technologies. Such an integrated fronthaul/backhaul (denoted as 5G-Crosshaul) transport network will be software-controlled to adapt to the fluctuating capacity demand of the new generation air interfaces. Based on a proposed data- and control-plane architecture for 5G-Crosshaul, we propose a frame format common to both fronthaul and backhaul traffic as well as a corresponding abstraction of the forwarding behavior of the network elements. The common frame format and the forwarding abstraction define the information to be exchanged at the southbound interface (SBI) of the 5G-Crosshaul Control Infrastructure (XCI). This paper derives requirements for the SBI from 5G use cases.The authors of this paper have been sponsored in part by the project H2020-ICT-2014-2 “5G-Crosshaul”: The 5G integrated fronthaul/backhaul” (671598

Development of a research and innovation network on Fluoride and dental Fluorosis in latin america: Desenvolvimento da rede de pesquisa e inovação em Flúor e Fluorose dentária na américa latina

Dental Fluorosis is a growing public health problem in many parts of the world. Dental Fluorosis in the world youngster population is increasing, as it is highlighted in the latest Latin American epidemiological report. There are few   studies on fluorosis and its prevalence in the region.  These are the basis for the creation of this international network, including Chile, Colombia, Ecuador, Paraguay and Argentina. In these countries there has been a significant increase in Dental Fluorosis, with values between 50% and 60%. A central goal of this network is to understand the “production-consumption source”, environment and the monitoring of systemic fluoride exposure, key to promote the benefits of fluorides and minimize the risks of chronic overexposure, leading to fluorosis. The significant increase in fluorosis in the Latin American region led to the formation of this research network. Its aim is to create a network of research centers in Latin America based on the management of spaces for communication, exchange and generation of knowledge on the subject of fluorides and dental fluorosis, and to generate products that can be used as inputs for public policy in the national health systems of the countries

Dataplane Measurements on a Fronthaul and Backhaul integrated network

Future transport networks serving next generation accesses are expected to carry both fronthaul (FH) and backhaul (BH) traffic simultaneously. This new concept of network which integrates the FH and BH traffic over the same transport substrate is called Crosshaul. A Crosshaul network will use heterogeneous technologies, such as fiber, mmWave, or microwave, and selects the most appropriates ones depending on the use case. Moreover, the softwarization/virtualization trend on the networking industry indicates that Virtual Network Functions (VNFs) will process and exchange both BH and FH data plane traffic. This paper presents performance measurements on promising technologies for the implementation of a Crosshaul network. We investigate to which extent the requirements to carry FH traffic are satisfied by mmWave links, software and multi-layer hardware switches

El número y tamaño de las aftas afectan la calidad de vida

19 p.Las aftas son úlceras dolorosas recurrentes orales que pueden afectar importantes actividades diarias, como la higiene oral y la alimentación. En este estudio observacional prospectivo mostramos que, durante los episodios de úlceras, los pacientes reportan una peor calidad de vida en comparación a los periodos libre de úlceras, y que ese impacto se asocia de forma positiva con el número y tamaño de las lesiones. Nuestros resultados sugieren que, si se interviene de forma local, se podría lograr un alivio general del cuadro. Palabras clave: estomatitis aftosa, calidad de vida, estudios de casos y controle

Removing of Direct Red 83:1 using α- and HP-α-CDs polymerized with epichlorohydrin: Kinetic and equilibrium studies

The adsorption properties of two cyclodextrin-epichlorohydrin polymers to remove Direct Red 83:1 textile dye from wastewater solutions was evaluated. Adsorption studies were performed in a batch reactor, and the efficiency of the polymers under different parametric values such as contact time, adsorbent dosage, initial dye concentration, pH of initial solution and temperature was followed by spectrophotometry. Both Langmuir and Freundlich equations were used to fit the equilibrium isotherms and the kinetic data were analyzed by the pseudo-first-order and pseudo-second-order models. Adsorption process follows a pseudo-second-order kinetic and was influenced by intraparticle diffusion model, dye concentration and contact time, reaching equilibrium within the first 30 min. Experimental data were better fitted to Freundlich isotherm model than to Langmuir and Temkin isotherms. Since about 93% of dye removal was achieved under optimized conditions, the α-cyclodextrin-epichlorohydrin polymer seems to be a useful device for removing Direct Red 83:1 from aqueous solutions and industrial effluents.Ciencias Ambientale

Long-Term Real-World Effectiveness and Safety of Ustekinumab in Crohn’s Disease Patients: The SUSTAIN Study

Background Large real-world-evidence studies are required to confirm the durability of response, effectiveness, and safety of ustekinumab in Crohn’s disease (CD) patients in real-world clinical practice. Methods A retrospective, multicentre study was conducted in Spain in patients with active CD who had received ≥1 intravenous dose of ustekinumab for ≥6 months. Primary outcome was ustekinumab retention rate; secondary outcomes were to identify predictive factors for drug retention, short-term remission (week 16), loss of response and predictive factors for short-term efficacy and loss of response, and ustekinumab safety. Results A total of 463 patients were included. Mean baseline Harvey-Bradshaw Index was 8.4. A total of 447 (96.5%) patients had received prior biologic therapy, 141 (30.5%) of whom had received ≥3 agents. In addition, 35.2% received concomitant immunosuppressants, and 47.1% had ≥1 abdominal surgery. At week 16, 56% had remission, 70% had response, and 26.1% required dose escalation or intensification; of these, 24.8% did not subsequently reduce dose. After a median follow-up of 15 months, 356 (77%) patients continued treatment. The incidence rate of ustekinumab discontinuation was 18% per patient-year of follow-up. Previous intestinal surgery and concomitant steroid treatment were associated with higher risk of ustekinumab discontinuation, while a maintenance schedule every 12 weeks had a lower risk; neither concomitant immunosuppressants nor the number of previous biologics were associated with ustekinumab discontinuation risk. Fifty adverse events were reported in 39 (8.4%) patients; 4 of them were severe (2 infections, 1 malignancy, and 1 fever). Conclusions Ustekinumab is effective and safe as short- and long-term treatment in a refractory cohort of CD patients in real-world clinical practice

Using Interpretable Machine Learning to Identify Baseline Predictive Factors of Remission and Drug Durability in Crohn’s Disease Patients on Ustekinumab

Ustekinumab has shown efficacy in Crohn's Disease (CD) patients. To identify patient profiles of those who benefit the most from this treatment would help to position this drug in the therapeutic paradigm of CD and generate hypotheses for future trials. The objective of this analysis was to determine whether baseline patient characteristics are predictive of remission and the drug durability of ustekinumab, and whether its positioning with respect to prior use of biologics has a significant effect after correcting for disease severity and phenotype at baseline using interpretable machine learning. Patients' data from SUSTAIN, a retrospective multicenter single-arm cohort study, were used. Disease phenotype, baseline laboratory data, and prior treatment characteristics were documented. Clinical remission was defined as the Harvey Bradshaw Index <= 4 and was tracked longitudinally. Drug durability was defined as the time until a patient discontinued treatment. A total of 439 participants from 60 centers were included and a total of 20 baseline covariates considered. Less exposure to previous biologics had a positive effect on remission, even after controlling for baseline disease severity using a non-linear, additive, multivariable model. Additionally, age, body mass index, and fecal calprotectin at baseline were found to be statistically significant as independent negative risk factors for both remission and drug survival, with further risk factors identified for remission

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

We report a medium‐throughput drug‐screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metastasis, we identified several vulnerabilities. Among them, a blood–brain barrier permeable HSP90 inhibitor showed high potency against mouse and human brain metastases at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery. Furthermore, in situ proteomic analysis applied to metastases treated with the chaperone inhibitor uncovered a novel molecular program in brain metastasis, which includes biomarkers of poor prognosis and actionable mechanisms of resistance. Our work validates METPlatform as a potent resource for metastasis research integrating drug‐screening and unbiased omic approaches that is compatible with human samples. Thus, this clinically relevant strategy is aimed to personalize the management of metastatic disease in the brain and elsewhere

Un discurrir en el hábitat más íntimo del ser [humano]

¿Qué es una Casa? ¿Qué significa LA CASA? Resulta muy diferente definir LA CASA en términos de concepto que definirla en términos de significado. En la Psicología, se utilizan dos términos relacionados con cada objeto: significado y significante. El significado hace referencia al concepto en sí y, en ese sentido, una casa sería un lugar para habitar, es decir, “un techo encima de la cabeza”, en palabras del profesor mencionado por el editor de este libro. El significante, por su lado, hace referencia al sentido, a la representación mental, al símbolo, a la imagen, a la percepción que, de ese concepto, pueda construir cada persona y, en ese sentido, puede evocar otros conceptos como hogar, refugio, protección, unión, afecto, recuerdos, oportunidades, valores, sabores, olores, eventos, familia, pareja, realización, pasado, futuro, etc