New insight into the Pleistocene deposits of Monte delle Piche, Rome, and remarks on the biochronology of Hippopotamus (Mammalia, Hippopotamidae) and Stephanorhinus etruscus (Mammalia, Rhinocerotidae) in Italy

Several large mammal assemblages have been collected in the Roman basin since the XIX century, but they usually lack any stratigraphic datum or details about the fossiliferous localities. In this work, the stratigraphic provenance of large mammal remains discovered at Monte delle Piche (Rome) is investigated. The systematic revision of these specimens allows the recording of the presence of Hippopotamus sp., Stephanorhinus sp. and Stephanorhinus etruscus. On the basis of micropalaeontological analysis performed on sediment sampled from the studied specimens and considering the stratigraphy of the area, two fossiliferous levels are recognised at Monte delle Piche. The remain of the hippopotamus was collected in fluvial gravels and sand deposits, in which the presence of Cyprideis is also recorded. This deposit is chronologically related to the latest Early-early Middle Pleistocene. Hippopotamus was present in Italy and Western Europe from the latest Villafranchian to MIS 4/3. The mandible of S. etruscus was collected in marine deposits along with abundant foraminifera and ostracods, which correlate with the late Early Pleistocene. Stephanorhinus etruscus occurred in Western Europe at the beginning of the Villafranchian, and it was documented until the end of the Villafranchian in Italy and until the Early-Middle Pleistocene transition in the Iberian Peninsula

Can Twitter be a source of information on allergy? Correlation of pollen counts with tweets reporting symptoms of allergic rhinoconjunctivitis and names of antihistamine drugs

Pollen forecasts are in use everywhere to inform therapeutic decisions for patients with allergic rhinoconjunctivitis (ARC). We exploited data derived from Twitter in order to identify tweets reporting a combination of symptoms consistent with a case definition of ARC and those reporting the name of an antihistamine drug. In order to increase the sensitivity of the system, we applied an algorithm aimed at automatically identifying jargon expressions related to medical terms. We compared weekly Twitter trends with National Allergy Bureau weekly pollen counts derived from US stations, and found a high correlation of the sum of the total pollen counts from each stations with tweets reporting ARC symptoms (Pearson's correlation coefficient: 0.95) and with tweets reporting antihistamine drug names (Pearson's correlation coefficient: 0.93). Longitude and latitude of the pollen stations affected the strength of the correlation. Twitter and other social networks may play a role in allergic disease surveillance and in signaling drug consumptions trends

Proof-of-principle of a new geometry for sampling calorimetry using inorganic scintillator plates

A novel geometry for a sampling calorimeter employing inorganic scintillators as an active medium is presented. To overcome the mechanical challenges of construction, an innovative light collection geometry has been pioneered, that minimises the complexity of construction. First test results are presented, demonstrating a successful signal extraction. The geometry consists of a sampling calorimeter with passive absorber layers interleaved with layers of an active medium made of inorganic scintillating crystals. Wavelength-shifting (WLS) fibres run along the four long, chamfered edges of the stack, transporting the light to photodetectors at the rear. To maximise the amount of scintillation light reaching the WLS fibres, the scintillator chamfers are depolished. It is shown herein that this concept is working for cerium fluoride (CeF$_3$) as a scintillator. Coupled to it, several different types of materials have been tested as WLS medium. In particular, materials that might be sufficiently resistant to the High-Luminosity Large Hadron Collider radiation environment, such as cerium-doped Lutetium-Yttrium Orthosilicate (LYSO) and cerium-doped quartz, are compared to conventional plastic WLS fibres. Finally, an outlook is presented on the possible optimisation of the different components, and the construction and commissioning of a full calorimeter cell prototype is presented.Comment: Submitted to Proceedings CALOR 2014, the 16th International Conference on Calorimetry in High-Energy Physics, Giessen (Germany) 6 - 11 April 2014. To be published in Journal of Physics: Conference Series (10 pages, 15 figures

Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML

HTIF1α, a transcription coactivator which is able to mediate RARα activity and functionally interact with PML, is encoded by a gene on chromosome 7q32–34, which is a critical region in acute myeloid leukemias (AML). With the assumption that this gene may be related to AML, we investigated the HTIF1α DNA structure and RNA expression in leukemic cells from 36 M1–M5 AML patients (28 ‘de novo’ and eight ‘secondary’ to myelodysplastic syndrome (MDS)). Abnormal HTIF1α DNA fragments were never found, whereas loss of HTIF1α DNA was observed in the patients with chromosome 7q32 deletion and translocation, and in one case without detectable chromosome 7 abnormality. HTIF1α RNA was found in acute myelocytic leukemic blasts, and was almost undetectable in normal mononuclear cells. The expression varied among the patients: higher in M1 to M3 subtypes, with the highest values in M1; low levels were constantly observed in M4 and M5 AML. In addition, HTIF1α was significantly overexpressed in MDS-related AML (MDR-AML), but not in MDS. We also found that HTIF1α expression was high in myeloid cell lines. In myeloblastic HL60 and promyelocytic NB4 cells, induced to differentiate along the monocytic–macrophage pathway by TPA or vitamin D3, HTIF1α expression decreased, whereas it was maintained at high levels on induction to granulocytic differentiation by RA or DMSO. In K562 cells, HTIF1α RNA levels did not change after hemin-induced erythroid differentiation. These results suggest that HTIF1α could play a role in myeloid differentiation, being distinctly regulated in hematopoietic lineages

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling.

One challenge in biology is signal transduction monitoring in a physiological context. Intravital imaging techniques are revolutionizing our understanding of tumor and host cell behaviors in the tumor environment. However, these deep tissue imaging techniques have not yet been adopted to investigate the second messenger calcium (Ca2+). In the present study, we established conditions that allow the in vivo detection of Ca2+ signaling in three-dimensional tumor masses in mouse models. By combining intravital imaging and a skinfold chamber technique, we determined the ability of photodynamic cancer therapy to induce an increase in intracellular Ca2+ concentrations and, consequently, an increase in cell death in a p53-dependent pathway

Performance of a Tungsten-Cerium Fluoride Sampling Calorimeter in High-Energy Electron Beam Tests

A prototype for a sampling calorimeter made out of cerium fluoride crystals interleaved with tungsten plates, and read out by wavelength-shifting fibres, has been exposed to beams of electrons with energies between 20 and 150 GeV, produced by the CERN Super Proton Synchrotron accelerator complex. The performance of the prototype is presented and compared to that of a Geant4 simulation of the apparatus. Particular emphasis is given to the response uniformity across the channel front face, and to the prototype's energy resolution.Comment: 6 pages, 6 figures, Submitted to NIM

Interacting Multiple Try Algorithms with Different Proposal Distributions

We propose a new class of interacting Markov chain Monte Carlo (MCMC) algorithms designed for increasing the efficiency of a modified multiple-try Metropolis (MTM) algorithm. The extension with respect to the existing MCMC literature is twofold. The sampler proposed extends the basic MTM algorithm by allowing different proposal distributions in the multiple-try generation step. We exploit the structure of the MTM algorithm with different proposal distributions to naturally introduce an interacting MTM mechanism (IMTM) that expands the class of population Monte Carlo methods. We show the validity of the algorithm and discuss the choice of the selection weights and of the different proposals. We provide numerical studies which show that the new algorithm can perform better than the basic MTM algorithm and that the interaction mechanism allows the IMTM to efficiently explore the state space

Simulation of the growth of the 3D Rayleigh-Taylor instability in Supernova Remnants using an expanding reference frame

Context: The Rayleigh-Taylor instabilities generated by the deceleration of a supernova remnant during the ejecta-dominated phase are known to produce finger-like structures in the matter distribution which modify the geometry of the remnant. The morphology of supernova remnants is also expected to be modified when efficient particle acceleration occurs at their shocks. Aims: The impact of the Rayleigh-Taylor instabilities from the ejecta-dominated to the Sedov-Taylor phase is investigated over one octant of the supernova remnant. We also study the effect of efficient particle acceleration at the forward shock on the growth of the Rayleigh-Taylor instabilities. Methods: We modified the Adaptive Mesh Refinement code RAMSES to study with hydrodynamic numerical simulations the evolution of supernova remnants in the framework of an expanding reference frame. The adiabatic index of a relativistic gas between the forward shock and the contact discontinuity mimics the presence of accelerated particles. Results: The great advantage of the super-comoving coordinate system adopted here is that it minimizes numerical diffusion at the contact discontinuity, since it is stationary with respect to the grid. We propose an accurate expression for the growth of the Rayleigh-Taylor structures that connects smoothly the early growth to the asymptotic self-similar behaviour. Conclusions: The development of the Rayleigh-Taylor structures is affected, although not drastically, if the blast wave is dominated by cosmic rays. The amount of ejecta that makes it into the shocked interstellar medium is smaller in the latter case. If acceleration occurs at both shocks the extent of the Rayleigh-Taylor structures is similar but the reverse shock is strongly perturbed.Comment: 15 pages, 12 figures, accepted for publication in Astronomy and Astrophysics with minor editorial changes. Version with full resolution images can be found at http://www.lpl.arizona.edu/~ffrasche/~12692.pd

Socio-Economic and Clinical Factors as Predictors of Disease Evolution and Acute Events in COPD Patients

BACKGROUND: Socio-economic, cultural and environmental factors are becoming increasingly important determinants of chronic obstructive pulmonary disease (COPD). We conducted a study to investigate socio-demographic, lifestyle and clinical factors, and to assess their role as predictors of acute events (mortality or hospitalization for respiratory causes) in a group of COPD patients. METHODS: Subjects were recruited among outpatients who were undertaking respiratory function tests at the Pneumology Unit of the Sant'Orsola-Malpighi Hospital, Bologna. Patients were classified according to the GOLD Guidelines. RESULTS: 229 patients with COPD were included in the study, 44 with Mild, 68 Moderate, 52 Severe and 65 Very Severe COPD (GOLD stage). Significant differences among COPD stage, in terms of smoking status and fragility index, were detected. COPD stage significantly affected the values of all clinical tests (spirometry and ABG analysis). Kaplan-Meier estimates showed a significant difference between survival curves by COPD stage with lower event-free probability in very severe COPD stage. Significant risk factors for acute events were: underweight (HR = 4.08; 95% CI 1.01-16.54), having two or more comorbidities (HR = 4.71; 95% CI 2.52-8.83), belonging to moderate (HR = 3.50; 95% CI 1.01-12.18) or very severe COPD stage (HR = 8.23; 95% CI 2.35-28.85). CONCLUSIONS: Our findings indicate that fragility is associated with COPD stage and that comorbidities and the low body mass index are predictors of mortality or hospitalization. Besides spirometric analyses, FeNO measure and comorbidities, body mass index could also be considered in the management and monitoring of COPD patients