342 research outputs found
Efeito da Acupunctura nas Células NK em Doentes com Cancro Colorectal submetidos a Quimioterapia
Evaluation of immunoexpression and MDR1 promoter methylation levels in prostatic tissue samples
Os objectivos deste estudo foram: (1) Determinar os níveis de metilação do promotor do MDR1 em tecido prostático
com adenocarcinoma (CaP), neoplasia intraepitelial prostática de alto grau (HGPIN), hiperplasia benigna (BPH) e tecido
morfologicamente normal (MNP). (2) Correlacionar os níveis de metilação com a imunoexpressão da gp-P.
Os nossos resultados demonstram que a hipermetilação do MDR1 constitui um mecanismo eficaz de regulação da
sua expressão. Estudos futuros permitirão avaliar o impacto destes resultados na terapêutica do cancro da próstata.
Our aims were: (1) To determine the MDR1 methylation levels in tissue of Prostate cancer (PCa), high grade prostatic
intraepithelial neoplasia (HGPIN), benign prostatic hyperplasia (BPH) and morphologically normal prostate tissue
(MNP); (2) to correlate the methylation levels of the MDR1 promoter with the immunoexpression of P-gp.
Our results demonstrate that MDR1 hypermethylation constitutes an effective mechanism of P-gp expression regulation.
Future studies will be able to evaluate the impact of these results in the treatment of PCa patients
Evaluation of immunoexpression and MDR1 promoter methylation levels in prostatic tissue samples
Os objectivos deste estudo foram: (1) Determinar os níveis de metilação do promotor do MDR1 em tecido prostático
com adenocarcinoma (CaP), neoplasia intraepitelial prostática de alto grau (HGPIN), hiperplasia benigna (BPH) e tecido
morfologicamente normal (MNP). (2) Correlacionar os níveis de metilação com a imunoexpressão da gp-P.
Os nossos resultados demonstram que a hipermetilação do MDR1 constitui um mecanismo eficaz de regulação da
sua expressão. Estudos futuros permitirão avaliar o impacto destes resultados na terapêutica do cancro da próstata.
Our aims were: (1) To determine the MDR1 methylation levels in tissue of Prostate cancer (PCa), high grade prostatic
intraepithelial neoplasia (HGPIN), benign prostatic hyperplasia (BPH) and morphologically normal prostate tissue
(MNP); (2) to correlate the methylation levels of the MDR1 promoter with the immunoexpression of P-gp.
Our results demonstrate that MDR1 hypermethylation constitutes an effective mechanism of P-gp expression regulation.
Future studies will be able to evaluate the impact of these results in the treatment of PCa patients
Producción de textos en lenguas indígenas para uso escolar
En este trabajo presentamos una serie de reflexiones que son producto de diferentes investigaciones y actividades de extensión universitaria que venimos desarrollando -desde el año 1999- en el campo de la Educación Intercultural Bilingüe (EIB) junto a un colectivo de agentes educativos indígenas del Núcleo educativo de Santa Victoria Este (Departamento de Rivadavia), provincia de Salta. Lo que exponemos a continuación, centrado en la experiencia de producción grupal de materiales escritos en lenguas indígenas para uso escolar, intenta ser un aporte para la construcción de una EIB que contemple la diversidad lingüística y cultural, e incorpore las propuestas surgidas desde los propios sujetos.Fil: Petz, Ivanna Lys. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cervera Novo, Juan Pablo. No especifíca;Fil: Corbato, Graciela Irene. No especifíca;Fil: Hecht, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pais, Graciela. No especifíca;Fil: Schmidt, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Producción de textos en lenguas indígenas para uso escolar
En este trabajo presentamos una serie de reflexiones que son producto de diferentes investigaciones y actividades de extensión universitaria que venimos desarrollando -desde el año 1999- en el campo de la Educación Intercultural Bilingüe (EIB) junto a un colectivo de agentes educativos indígenas del Núcleo educativo de Santa Victoria Este (Departamento de Rivadavia), provincia de Salta. Lo que exponemos a continuación, centrado en la experiencia de producción grupal de materiales escritos en lenguas indígenas para uso escolar, intenta ser un aporte para la construcción de una EIB que contemple la diversidad lingüística y cultural, e incorpore las propuestas surgidas desde los propios sujetos.Fil: Petz, Ivanna Lys. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cervera Novo, Juan Pablo. No especifíca;Fil: Corbato, Graciela Irene. No especifíca;Fil: Hecht, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pais, Graciela. No especifíca;Fil: Schmidt, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis
Regular physical activity (PA) is increasingly promoted for people with rheumatic and musculoskeletal diseases as well as the general population. We evaluated if the public health recommendations for PA are applicable for people with inflammatory arthritis (iA; Rheumatoid Arthritis and Spondyloarthritis) and osteoarthritis (hip/knee OA) in order to develop evidence-based recommendations for advice and guidance on PA in clinical practice. The EULAR standardised operating procedures for the development of recommendations were followed. A task force (TF) (including rheumatologists, other medical specialists and physicians, health professionals, patient-representatives, methodologists) from 16 countries met twice. In the first TF meeting, 13 research questions to support a systematic literature review (SLR) were identified and defined. In the second meeting, the SLR evidence was presented and discussed before the recommendations, research agenda and education agenda were formulated. The TF developed and agreed on four overarching principles and 10 recommendations for PA in people with iA and OA. The mean level of agreement between the TF members ranged between 9.8 and 8.8. Given the evidence for its effectiveness, feasibility and safety, PA is advocated as integral part of standard care throughout the course of these diseases. Finally, the TF agreed on related research and education agendas. Evidence and expert opinion inform these recommendations to provide guidance in the development, conduct and evaluation of PA-interventions and promotion in people with iA and OA. It is advised that these recommendations should be implemented considering individual needs and national health systems.EULA
BLOOM: A 176B-Parameter Open-Access Multilingual Language Model
Large language models (LLMs) have been shown to be able to perform new tasks
based on a few demonstrations or natural language instructions. While these
capabilities have led to widespread adoption, most LLMs are developed by
resource-rich organizations and are frequently kept from the public. As a step
towards democratizing this powerful technology, we present BLOOM, a
176B-parameter open-access language model designed and built thanks to a
collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer
language model that was trained on the ROOTS corpus, a dataset comprising
hundreds of sources in 46 natural and 13 programming languages (59 in total).
We find that BLOOM achieves competitive performance on a wide variety of
benchmarks, with stronger results after undergoing multitask prompted
finetuning. To facilitate future research and applications using LLMs, we
publicly release our models and code under the Responsible AI License
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
The reference site collaborative network of the european innovation partnership on active and healthy ageing
Seventy four Reference Sites of the European Innovation
Partnership on Active and Healthy Ageing (EIP on AHA)
have been recognised by the European Commission in
2016 for their commitment to excellence in investing and
scaling up innovative solutions for active and healthy
ageing. The Reference Site Collaborative Network
(RSCN) brings together the EIP on AHA Reference Sites
awarded by the European Commission, and Candidate
Reference Sites into a single forum. The overarching goals
are to promote cooperation, share and transfer good
practice and solutions in the development and scaling up
of health and care strategies, policies and service delivery
models, while at the same time supporting the action
groups in their work. The RSCN aspires to be recognized
by the EU Commission as the principal forum and
authority representing all EIP on AHA Reference Sites.
The RSCN will contribute to achieve the goals of the EIP
on AHA by improving health and care outcomes for
citizens across Europe, and the development of sustainable
economic growth and the creation of jobs
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