379 research outputs found
Oncolog, Volume 37, Issue 04, October-December 1992
Universal access to health care requires insurance reform, says AMA\u27s Painter Tissue conservation techniques for patients with vulvar cancerhttps://openworks.mdanderson.org/oncolog/1040/thumbnail.jp
Climatic, edaphic, and biotic controls over storage and turnover of carbon in soils
Soil carbon, a major component of the global carbon inventory, has significant potential for change with changing climate and human land use. We applied the Century ecosystem model to a series of forest and grassland sites distributed globally to examine large-scale controls over soil carbon. Key site-specific parameters influencing soil carbon dynamics are soil texture and foliar lignin content; accordingly, we perturbed these variables at each site to establish a range of carbon concentrations and turnover times. We examined the simulated soil carbon stores, turnover times, and C:N ratios for correlations with patterns of independent variables. Results showed that soil carbon is related linearly to soil texture, increasing as clay content increases, that soil carbon stores and turnover time are related to mean annual temperature by negative exponential functions, and that heterotrophic respiration originates from recent detritus (∼50%), microbial turnover (∼30%), and soil organic matter (∼20%) with modest variations between forest and grassland ecosystems. The effect of changing temperature on soil organic carbon (SOC) estimated by Century is dSOC/dT= 183e−0.034T. Global extrapolation of this relationship leads to an estimated sensitivity of soil C storage to a temperature of −11.1 Pg° C−1, excluding extreme arid and organic soils. In Century, net primary production (NPP) and soil carbon are closely coupled through the N cycle, so that as temperatures increase, accelerated N release first results in fertilization responses, increasing C inputs. The Century-predicted effect of temperature on carbon storage is modified by as much as 100% by the N cycle feedback. Century-estimated soil C sensitivity (−11.1 Pg° C−1) is similar to losses predicted with a simple data-based calculation (−14.1 Pg° C−1). Inclusion of the N cycle is important for even first-order predictions of terrestrial carbon balance. If the NPP-SOC feedback is disrupted by land use or other disturbances, then SOC sensitivity can greatly exceed that estimated in our simulations. Century results further suggest that if climate change results in drying of organic soils (peats), soil carbon loss rates can be high
Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides
As part of an effort to identify agonists of TRPV1, a peripheral sensory nerve ion channel, high throughput screening of the NIH Small Molecule Repository (SMR) collection identified MLS002174161, a pentacyclic benzodiazepine. A synthesis effort was initiated that ultimately afforded racemic seco analogs 12 of the SMR compound via a silver mediated intramolecular [3+2] cycloaddition of an azo-methine ylide generated from α-iminoamides 11. The cycloaddition set four contiguous stereocenters and, in some cases, also spontaneously afforded imides 13 from 12. The synthesis of compounds 12, the features that facilitated the conversion of 12–13, and their partial agonist activity against TRPV1 are discussed
Search for Point Sources of Ultra-High Energy Cosmic Rays Above 40 EeV Using a Maximum Likelihood Ratio Test
We present the results of a search for cosmic ray point sources at energies
above 40 EeV in the combined data sets recorded by the AGASA and HiRes stereo
experiments. The analysis is based on a maximum likelihood ratio test using the
probability density function for each event rather than requiring an a priori
choice of a fixed angular bin size. No statistically significant clustering of
events consistent with a point source is found.Comment: 7 pages, 7 figures. Accepted for publication in The Astrophysical
Journa
An upper limit on the electron-neutrino flux from the HiRes detector
Air-fluorescence detectors such as the High Resolution Fly's Eye (HiRes)
detector are very sensitive to upward-going, Earth-skimming ultrahigh energy
electron-neutrino-induced showers. This is due to the relatively large
interaction cross sections of these high-energy neutrinos and to the
Landau-Pomeranchuk-Migdal (LPM) effect. The LPM effect causes a significant
decrease in the cross sections for bremsstrahlung and pair production, allowing
charged-current electron-neutrino-induced showers occurring deep in the Earth's
crust to be detectable as they exit the Earth into the atmosphere. A search for
upward-going neutrino-induced showers in the HiRes-II monocular dataset has
yielded a null result. From an LPM calculation of the energy spectrum of
charged particles as a function of primary energy and depth for
electron-induced showers in rock, we calculate the shape of the resulting
profile of these showers in air. We describe a full detector Monte Carlo
simulation to determine the detector response to upward-going
electron-neutrino-induced cascades and present an upper limit on the flux of
electron-neutrinos.Comment: 13 pages, 3 figures. submitted to Astrophysical Journa
Search for Correlations between HiRes Stereo Events and Active Galactic Nuclei
We have searched for correlations between the pointing directions of
ultrahigh energy cosmic rays observed by the High Resolution Fly's Eye
experiment and Active Galactic Nuclei (AGN) visible from its northern
hemisphere location. No correlations, other than random correlations, have been
found. We report our results using search parameters prescribed by the Pierre
Auger collaboration. Using these parameters, the Auger collaboration concludes
that a positive correlation exists for sources visible to their southern
hemisphere location. We also describe results using two methods for determining
the chance probability of correlations: one in which a hypothesis is formed
from scanning one half of the data and tested on the second half, and another
which involves a scan over the entire data set. The most significant
correlation found occurred with a chance probability of 24%.Comment: 13 pages, 1 table, 5 figure
Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery
Background: For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated
with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent with
the potential to reduce surgical bleeding; however, there is uncertainty about its efficacy and safety in noncardiac
surgery. Although usual perioperative care is commonly consistent with a hypertension-avoidance strategy (i.e.,
most patients continue their antihypertensive medications throughout the perioperative period and intraoperative
mean arterial pressures of 60 mmHg are commonly accepted), a hypotension-avoidance strategy may improve
perioperative outcomes
Observation of the Ankle and Evidence for a High-Energy Break in the Cosmic Ray Spectrum
We have measured the cosmic ray spectrum at energies above eV using
the two air fluorescence detectors of the High Resolution Fly's Eye experiment
operating in monocular mode. We describe the detector, PMT and atmospheric
calibrations, and the analysis techniques for the two detectors. We fit the
spectrum to models describing galactic and extragalactic sources. Our measured
spectrum gives an observation of a feature known as the ``ankle'' near eV, and strong evidence for a suppression near eV.Comment: 14 pages, 9 figures. To appear in Physics Letters B. Accepted versio
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression. We previously found single-nucleotide polymorphisms (SNPs) at the HNF1B locus to be associated with endometrial cancer, and now report extensive fine-mapping and in silico and laboratory analyses of this locus. Analysis of 1184 genotyped and imputed SNPs in 6608 Caucasian cases and 37 925 controls, and 895 Asian cases and 1968 controls, revealed the best signal of association for SNP rs11263763 (P = 8.4 × 10(-14), odds ratio = 0.86, 95% confidence interval = 0.82-0.89), located within HNF1B intron 1. Haplotype analysis and conditional analyses provide no evidence of further independent endometrial cancer risk variants at this locus. SNP rs11263763 genotype was associated with HNF1B mRNA expression but not with HNF1B methylation in endometrial tumor samples from The Cancer Genome Atlas. Genetic analyses prioritized rs11263763 and four other SNPs in high-to-moderate linkage disequilibrium as the most likely causal SNPs. Three of these SNPs map to the extended HNF1B promoter based on chromatin marks extending from the minimal promoter region. Reporter assays demonstrated that this extended region reduces activity in combination with the minimal HNF1B promoter, and that the minor alleles of rs11263763 or rs8064454 are associated with decreased HNF1B promoter activity. Our findings provide evidence for a single signal associated with endometrial cancer risk at the HNF1B locus, and that risk is likely mediated via altered HNF1B gene expression
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