About the initial mass function and HeII emission in young starbursts

We demonstrate that it is crucial to account for the evolution of the starburst population in order to derive reliable numbers of O stars from integrated spectra for burst ages t > 2 - 3 Myr. In these cases the method of Vacca & Conti (1992) and Vacca (1994) systematically underestimates the number of O stars. Therefore the current WR/O number ratios in Wolf-Rayet (WR) galaxies are overestimated. This questions recent claims about flat IMF slopes (alpha ~ 1-2) in these objects. If the evolution of the burst is properly treated we find that the observations are indeed compatible with a Salpeter IMF, in agreement with earlier studies. Including recent predictions from non-LTE, line blanketed model atmospheres which account for stellar winds, we synthesize the nebular and WR HeII 4686 emission in young starbursts. For metallicities 1/5 <= Z/Z_sun <= 1 we predict a strong nebular HeII emission due to a significant fraction of WC stars in early WR phases of the burst. For other metallicities broad WR emission will always dominate the HeII emission. Our predictions of the nebular HeII intensity agree well with the observations in WR galaxies and an important fraction of the giant HII regions where nebular HeII is detected. We propose further observational tests of our result.Comment: ApJ Letters, accepted. 8 pages LaTeX including 3 PostScript figures, uses AASTeX and psfig macros. PostScript file also available at ftp://ftp.stsci.edu/outside-access/out.going/schaerer/imf.p

Clinical Use and Effectiveness of Lipid Lowering Therapies in Diabetes Mellitus—An Observational Study from the Swedish National Diabetes Register

OBJECTIVES: To describe the use and evaluate the effectiveness of different lipid lowering therapies in unselected patients with type 1 and type 2 diabetes in clinical practice. DESIGN: Observational population-based study using the personal identification number to link information from the National Diabetes Register, the Prescribed Drug Register and the Patient register in Sweden. All patients in the NDR aged 18-75 years with diabetes more than one year were eligible, but only patients starting any lipid lowering treatment with at least three prescriptions 1 July 2006-30 June 2007 were included (n = 37,182). The mean blood lipid levels in 2008 and reductions in LDL cholesterol were examined. RESULTS: Blood lipid levels were similar in patients treated with simvastatin, atorvastatin and rosuvastatin, showing similar lipid lowering effect as currently used. Users of pravastatin, fluvastatin, ezetimib and fibrate more seldom reach treatment goals. Moderate daily doses of the statins were used, with 76% of simvastatin users taking 20 mg or less, 48% of atorvastatin users taking 10 mg, 55% of pravastatin users taking 20 mg, and 76% of rosuvastatin users taking 5 or 10 mg. CONCLUSIONS: This observational study shows that the LDL-C levels in patients taking simvastatin, atorvastatin or rosuvastatin are very similar as currently used, as well as their LDL-C lowering abilities. There is potential to intensify lipid lowering treatment to reduce the remaining high residual risk and achieve better fulfilment of treatment goals, since the commonly used doses are only low to moderate

A multi-wavelength census of star formation activity in the young embedded cluster around Serpens/G3-G6

Aims. The aim of this paper is to characterise the star formation activity in the poorly studied embedded cluster Serpens/G3-G6, located ~ 45' (3 pc) to the south of the Serpens Cloud Core, and to determine the luminosity and mass functions of its population of Young Stellar Objects (YSOs). Methods. Multi-wavelength broadband photometry was obtained to sample the near and mid-IR spectral energy distributions to separate YSOs from field stars and classify the YSO evolutionary stage. ISOCAM mapping in the two filters LW2 (5-8.5 um) and LW3 (12-18 um) of a 19' x 16' field was combined with JHKs data from 2MASS, Ks data from Arnica/NOT, and L' data from SIRCA/NOT. Continuum emission at 1.3 mm (IRAM) and 3.6 cm (VLA) was mapped to study the cloud structure and the coldest/youngest sources. Deep narrow band imaging at the 2.12 um S(1) line of H2 from NOTCam/NOT was obtained to search for signs of bipolar outflows. Results. We have strong evidence for a stellar population of 31 Class II sources, 5 flat-spectrum sources, 5 Class I sources, and two Class 0 sources. Our method does not sample the Class III sources. The cloud is composed of two main dense clumps aligned along a ridge over ~ 0.5 pc plus a starless core coinciding with absorption features seen in the ISOCAM maps. We find two S-shaped bipolar collimated flows embedded in the NE clump, and propose the two driving sources to be a Class 0 candidate (MMS3) and a double Class I (MMS2). For the Class II population we find a best age of ~ 2 Myr and compatibility with recent Initial Mass Functions (IMFs) by comparing the observed Class II luminosity function (LF), which is complete to 0.08 L_sun, to various model LFs with different star formation scenarios and input IMFs.Comment: 18 pages, 16 figures, 3 online tables, accepted by A&

Evidence of triggered star formation in G327.3-0.6. Dust-continuum mapping of an infrared dark cloud with P-ArT\'eMiS

Aims. Expanding HII regions and propagating shocks are common in the environment of young high-mass star-forming complexes. They can compress a pre-existing molecular cloud and trigger the formation of dense cores. We investigate whether these phenomena can explain the formation of high-mass protostars within an infrared dark cloud located at the position of G327.3-0.6 in the Galactic plane, in between two large infrared bubbles and two HII regions. Methods: The region of G327.3-0.6 was imaged at 450 ? m with the CEA P-ArT\'eMiS bolometer array on the Atacama Pathfinder EXperiment telescope in Chile. APEX/LABOCA and APEX-2A, and Spitzer/IRAC and MIPS archives data were used in this study. Results: Ten massive cores were detected in the P-ArT\'eMiS image, embedded within the infrared dark cloud seen in absorption at both 8 and 24 ?m. Their luminosities and masses indicate that they form high-mass stars. The kinematical study of the region suggests that the infrared bubbles expand toward the infrared dark cloud. Conclusions: Under the influence of expanding bubbles, star formation occurs in the infrared dark areas at the border of HII regions and infrared bubbles.Comment: 4 page

The Aquila prestellar core population revealed by Herschel

The origin and possible universality of the stellar initial mass function (IMF) is a major issue in astrophysics. One of the main objectives of the Herschel Gould Belt Survey is to clarify the link between the prestellar core mass function (CMF) and the IMF. We present and discuss the core mass function derived from Herschel data for the large population of prestellar cores discovered with SPIRE and PACS in the Aquila Rift cloud complex at d ~ 260 pc. We detect a total of 541 starless cores in the entire ~11 deg^2 area of the field imaged at 70-500 micron with SPIRE/PACS. Most of these cores appear to be gravitationally bound, and thus prestellar in nature. Our Herschel results confirm that the shape of the prestellar CMF resembles the stellar IMF, with much higher quality statistics than earlier submillimeter continuum ground-based surveys

Herschel observations of embedded protostellar clusters in the Rosette Molecular Cloud

The Herschel OB young stellar objects survey (HOBYS) has observed the Rosette molecular cloud, providing an unprecedented view of its star formation activity. These new far-infrared data reveal a population of compact young stellar objects whose physical properties we aim to characterise. We compiled a sample of protostars and their spectral energy distributions that covers the near-infrared to submillimetre wavelength range. These were used to constrain key properties in the protostellar evolution, bolometric luminosity, and envelope mass and to build an evolutionary diagram. Several clusters are distinguished including the cloud centre, the embedded clusters in the vicinity of luminous infrared sources, and the interaction region. The analysed protostellar population in Rosette ranges from 0.1 to about 15 Msun with luminosities between 1 and 150 Lsun, which extends the evolutionary diagram from low-mass protostars into the high-mass regime. Some sources lack counterparts at near- to mid-infrared wavelengths, indicating extreme youth. The central cluster and the Phelps & Lada 7 cluster appear less evolved than the remainder of the analysed protostellar population. For the central cluster, we find indications that about 25% of the protostars classified as Class I from near- to mid-infrared data are actually candidate Class 0 objects. As a showcase for protostellar evolution, we analysed four protostars of low- to intermediate-mass in a single dense core, and they represent different evolutionary stages from Class 0 to Class I. Their mid- to far-infrared spectral slopes flatten towards the Class I stage, and the 160 to 70um flux ratio is greatest for the presumed Class 0 source. This shows that the Herschel observations characterise the earliest stages of protostellar evolution in detail.Comment: Astronomy & Astrophysics letter, 6 pages, 4 figures, accepted for publication in the Special Issue for Herschel first result

The Mid-Infrared Instrument for the James Webb Space Telescope, III: MIRIM, The MIRI Imager

In this article, we describe the MIRI Imager module (MIRIM), which provides broad-band imaging in the 5 - 27 microns wavelength range for the James Webb Space Telescope. The imager has a 0"11 pixel scale and a total unobstructed view of 74"x113". The remainder of its nominal 113"x113" field is occupied by the coronagraphs and the low resolution spectrometer. We present the instrument optical and mechanical design. We show that the test data, as measured during the test campaigns undertaken at CEA-Saclay, at the Rutherford Appleton Laboratory, and at the NASA Goddard Space Flight Center, indicate that the instrument complies with its design requirements and goals. We also discuss the operational requirements (multiple dithers and exposures) needed for optimal scientific utilization of the MIRIM.Comment: 29 pages, 9 figure

A Herschel study of the properties of starless cores in the Polaris Flare dark cloud region using PACS and SPIRE

The Polaris Flare cloud region contains a great deal of extended emission. It is at high declination and high Galactic latitude. It was previously seen strongly in IRAS Cirrus emission at 100 microns. We have detected it with both PACS and SPIRE on Herschel. We see filamentary and low-level structure. We identify the five densest cores within this structure. We present the results of a temperature, mass and density analysis of these cores. We compare their observed masses to their virial masses, and see that in all cases the observed masses lie close to the lower end of the range of estimated virial masses. Therefore, we cannot say whether they are gravitationally bound prestellar cores. Nevertheless, these are the best candidates to be potentialprestellar cores in the Polaris cloud region.Comment: 5 pages, 2 figures, accepted by A&

New Models for Wolf-Rayet and O Star Populations in Young Starbursts

Using the latest stellar evolution models, theoretical stellar spectra, and a compilation of observed emission line strengths from Wolf-Rayet (WR) stars, we construct evolutionary synthesis models for young starbursts. We explicitly distinguish between the various WR subtypes (WN, WC, WO), and we treat O and Of stars separately. We provide detailed predictions of UV and optical emission line strengths for both the WR stellar lines and the major nebular hydrogen and helium emission lines, as a function of several input parameters related to the starburst episode. We also derive the theoretical frequency of WR-rich starbursts. We then discuss: nebular HeII 4686 emission, the contribution of WR stars to broad Balmer line emission, techniques used to derive the WR and O star content from integrated spectra, and explore the implications of the formation of WR stars through mass transfer in close binary systems in instantaneous bursts. The observational features predicted by our models allow a detailed quantitative determination of the massive star population in a starburst region (particularly in so-called "WR galaxies") from its integrated spectrum and provide a means of deriving the burst properties (e.g., duration, age) and the parameters of the initial mass function of young starbursts. (Abridged abstract)Comment: Accepted by ApJ Supplements. LaTeX using aasmp4, psfigs macros. 49 pages including 23 figures. Paper (full, or text/figures separated) and detailed model results available at http://www.stsci.edu/ftp/science/starburst/sv97.htm

Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells

The endocrine disrupting chemical, bisphenol A (BPA), has been shown to accelerate the rate of adipogenesis and increase the amount of triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. The objective of this study was to investigate if that observation is mirrored in human primary cells. Here we investigated the effect of BPA on adipogenesis in cultured human primary adult stem cells. Continuous exposure to BPA throughout the 14 days of differentiation dramatically reduced triglyceride accumulation and suppressed gene transcription of the lipogenic enzyme, lipoprotein lipase (LPL). Results presented in the present study show for the first time that BPA can reduce triglyceride accumulation during adipogenesis by attenuating the expression of LPL gene transcription. Also, by employing image cytometric analysis rather than conventional Oil red O staining techniques we show that BPA regulates triglyceride accumulation in a manner which does not appear to effect adipogenesis per se