A Primary Care Nurse-Delivered Walking Intervention in Older Adults: PACE (Pedometer Accelerometer Consultation Evaluation)-Lift Cluster Randomised Controlled Trial.

Background: Brisk walking in older people can increase step-counts and moderate to vigorous intensity physical activity (MVPA) in ≥10-minute bouts, as advised in World Health Organization guidelines. Previous interventions have reported step-count increases, but not change in objectively measured MVPA in older people. We assessed whether a primary care nurse-delivered complex intervention increased objectively measured step-counts and MVPA. Methods and Findings: A total of 988 60–75 year olds, able to increase walking and randomly selected from three UK family practices, were invited to participate in a parallel two-arm cluster randomised trial; randomisation was by household. Two-hundred-ninety-eight people from 250 households were randomised between 2011 and 2012; 150 individuals to the intervention group, 148 to the usual care control group. Intervention participants received four primary care nurse physical activity (PA) consultations over 3 months, incorporating behaviour change techniques, pedometer step-count and accelerometer PA intensity feedback, and an individual PA diary and plan. Assessors were not blinded to group status, but statistical analyses were conducted blind. The primary outcome was change in accelerometry assessed average daily step-counts between baseline and 3 months, with change at 12 months a secondary outcome. Other secondary outcomes were change from baseline in time in MVPA weekly in ≥10-minute bouts, accelerometer counts, and counts/minute at 3 months and 12 months. Other outcomes were adverse events, anthropometric measures, mood, and pain. Qualitative evaluations of intervention participants and practice nurses assessed the intervention’s acceptability. At 3 months, eight participants had withdrawn or were lost to follow-up, 280 (94%) individuals provided primary outcome data. At 3 months changes in both average daily step-counts and weekly MVPA in ≥10-minute bouts were significantly higher in the intervention than control group: by 1,037 (95% CI 513–1,560) steps/day and 63 (95% CI 40–87) minutes/week, respectively. At 12 months corresponding differences were 609 (95% CI 104–1,115) steps/day and 40 (95% CI 17–63) minutes/week. Counts and counts/minute showed similar effects to steps and MVPA. Adverse events, anthropometry, mood, and pain were similar in the two groups. Participants and practice nurses found the intervention acceptable and enjoyable. Conclusions : The PACE-Lift trial increased both step-counts and objectively measured MVPA in ≥10-minute bouts in 60–75 year olds at 3 and 12 months, with no effect on adverse events. To our knowledge, this is the first trial in this age group to demonstrate objective MVPA increases and highlights the value of individualised support incorporating objective PA assessment in a primary care setting. Trial Registration: Controlled-Trials.com ISRCTN4212256

Probabilistic representation for solutions of an irregular porous media type equation: the degenerate case

We consider a possibly degenerate porous media type equation over all of $\R^d$ with $d = 1$, with monotone discontinuous coefficients with linear growth and prove a probabilistic representation of its solution in terms of an associated microscopic diffusion. This equation is motivated by some singular behaviour arising in complex self-organized critical systems. The main idea consists in approximating the equation by equations with monotone non-degenerate coefficients and deriving some new analytical properties of the solution

The initial conditions of star formation in the Ophiuchus main cloud: Kinematics of the protocluster condensations

The earliest phases of clustered star formation and the origin of the stellar initial mass function (IMF) are currently much debated. In order to constrain the origin of the IMF, we investigated the internal and relative motions of starless condensations and protostars previously detected by us in the dust continuum at 1.2mm in the L1688 protocluster of the Ophiuchus molecular cloud complex. The starless condensations have a mass spectrum resembling the IMF and are therefore likely representative of the initial stages of star formation in the protocluster. We carried out detailed molecular line observations, including some N2H+(1-0) mapping, of the Ophiuchus protocluster condensations using the IRAM 30m telescope. We measured subsonic or at most transonic levels of internal turbulence within the condensations, implying virial masses which generally agree within a factor of ~ 2 with the masses derived from the 1.2mm dust continuum. This supports the notion that most of the L1688 starless condensations are gravitationally bound and prestellar in nature. We measured a global one-dimensional velocity dispersion of less than 0.4 km/s between condensations. This small relative velocity dispersion implies that, in general, the condensations do not have time to interact with one another before evolving into pre-main sequence objects. Our observations support the view that the IMF is partly determined by cloud fragmentation at the prestellar stage. Competitive accretion is unlikely to be the dominant mechanism at the protostellar stage in the Ophiuchus protocluster, but it may possibly govern the growth of starless, self-gravitating condensations initially produced by gravoturbulent fragmentation toward an IMF, Salpeter-like mass spectrum.Comment: 17 pages, 8 figures. A&A, in press (v2: notes added to Table 3

Index Theorem and Overlap Formalism with Naive and Minimally Doubled Fermions

We present a theoretical foundation for the Index theorem in naive and minimally doubled lattice fermions by studying the spectral flow of a Hermitean version of Dirac operators. We utilize the point splitting method to implement flavored mass terms, which play an important role in constructing proper Hermitean operators. We show the spectral flow correctly detects the index of the would-be zero modes which is determined by gauge field topology. Using the flavored mass terms, we present new types of overlap fermions from the naive fermion kernels, with a number of flavors that depends on the choice of the mass terms. We succeed to obtain a single-flavor naive overlap fermion which maintains hypercubic symmetry.Comment: 27 pages, 17 figures; references added, version accepted in JHE

On the AdS/CFT Dual of Deconstruction

We consider a class of non-supersymmetric gauge theories obtained by orbifolding the N=4 super-Yang-Mills theories. We focus on the resulting quiver theories in their deconstructed phase, both at small and large coupling, where a fifth dimension opens up. In particular we investigate the r\^ole played by this extra dimension when evaluating the rectangular Wilson loops encoding the interaction potential between quarks located at different points in the orbifold. The large coupling potential of the deconstructed quiver theory is determined using the AdS/CFT correspondence and analysing the corresponding minimal surface solution for the dual gravitational metric. At small coupling, the potential between quarks decreases with their angular distance while at strong coupling we find a linear dependence at large distance along the (deconstructed) fifth dimension.Comment: 19 pages, 3 figure

Asymptotic behaviour of a semilinear elliptic system with a large exponent

Consider the problem \begin{eqnarray*} -\Delta u &=& v^{\frac 2{N-2}},\quad v>0\quad {in}\quad \Omega, -\Delta v &=& u^{p},\:\:\:\quad u>0\quad {in}\quad \Omega, u&=&v\:\:=\:\:0 \quad {on}\quad \partial \Omega, \end{eqnarray*} where $\Omega$ is a bounded convex domain in $\R^N,$ $N>2,$ with smooth boundary $\partial \Omega.$ We study the asymptotic behaviour of the least energy solutions of this system as $p\to \infty.$ We show that the solution remain bounded for $p$ large and have one or two peaks away form the boundary. When one peak occurs we characterize its location.Comment: 16 pages, submmited for publicatio

Formation of a stable deacagonal quasicrystalline Al-Pd-Mn surface layer

We report the in situ formation of an ordered equilibrium decagonal Al-Pd-Mn quasicrystal overlayer on the 5-fold symmetric surface of an icosahedral Al-Pd-Mn monograin. The decagonal structure of the epilayer is evidenced by x-ray photoelectron diffraction, low-energy electron diffraction and electron backscatter diffraction. This overlayer is also characterized by a reduced density of states near the Fermi edge as expected for quasicrystals. This is the first time that a millimeter-size surface of the stable decagonal Al-Pd-Mn is obtained, studied and compared to its icosahedral counterpart.Comment: Submitted to Phys. Ref. Lett. (18 July 2001

A multi-wavelength census of star formation activity in the young embedded cluster around Serpens/G3-G6

Aims. The aim of this paper is to characterise the star formation activity in the poorly studied embedded cluster Serpens/G3-G6, located ~ 45' (3 pc) to the south of the Serpens Cloud Core, and to determine the luminosity and mass functions of its population of Young Stellar Objects (YSOs). Methods. Multi-wavelength broadband photometry was obtained to sample the near and mid-IR spectral energy distributions to separate YSOs from field stars and classify the YSO evolutionary stage. ISOCAM mapping in the two filters LW2 (5-8.5 um) and LW3 (12-18 um) of a 19' x 16' field was combined with JHKs data from 2MASS, Ks data from Arnica/NOT, and L' data from SIRCA/NOT. Continuum emission at 1.3 mm (IRAM) and 3.6 cm (VLA) was mapped to study the cloud structure and the coldest/youngest sources. Deep narrow band imaging at the 2.12 um S(1) line of H2 from NOTCam/NOT was obtained to search for signs of bipolar outflows. Results. We have strong evidence for a stellar population of 31 Class II sources, 5 flat-spectrum sources, 5 Class I sources, and two Class 0 sources. Our method does not sample the Class III sources. The cloud is composed of two main dense clumps aligned along a ridge over ~ 0.5 pc plus a starless core coinciding with absorption features seen in the ISOCAM maps. We find two S-shaped bipolar collimated flows embedded in the NE clump, and propose the two driving sources to be a Class 0 candidate (MMS3) and a double Class I (MMS2). For the Class II population we find a best age of ~ 2 Myr and compatibility with recent Initial Mass Functions (IMFs) by comparing the observed Class II luminosity function (LF), which is complete to 0.08 L_sun, to various model LFs with different star formation scenarios and input IMFs.Comment: 18 pages, 16 figures, 3 online tables, accepted by A&

Numerical properties of staggered quarks with a taste-dependent mass term

The numerical properties of staggered Dirac operators with a taste-dependent mass term proposed by Adams [1,2] and by Hoelbling [3] are compared with those of ordinary staggered and Wilson Dirac operators. In the free limit and on (quenched) interacting configurations, we consider their topological properties, their spectrum, and the resulting pion mass. Although we also consider the spectral structure, topological properties, locality, and computational cost of an overlap operator with a staggered kernel, we call attention to the possibility of using the Adams and Hoelbling operators without the overlap construction. In particular, the Hoelbling operator could be used to simulate two degenerate flavors without additive mass renormalization, and thus without fine-tuning in the chiral limit.Comment: 14 pages, 9 figures. V2: published version; important note added regarding Hoelbling fermions, otherwise minor change

Configurational Entropy and Diffusivity of Supercooled Water

We calculate the configurational entropy S_conf for the SPC/E model of water for state points covering a large region of the (T,rho) plane. We find that (i) the (T,rho) dependence of S_conf correlates with the diffusion constant and (ii) that the line of maxima in S_conf tracks the line of density maxima. Our simulation data indicate that the dynamics are strongly influenced by S_conf even above the mode-coupling temperature T_MCT(rho).Comment: Significant update of reference