581 research outputs found
Determinants of Skills Shortages and Hard-to-Fill Vacancies in the Hospitality Sector
The aim of this paper is to analyse the regional determinants of hard-to-fill vacancies and skills shortages in the hospitality sector. The data source for this study was generated in the year 2000 and includes information on 181 hotels and 121 restaurants in Andalusia. The results of the estimations show that hourly net wages are the main instrument firms use to reduce hard-to-fill vacancies and skills shortages. However, there are several factors affecting the conditions of local labour markets — such as unemployment rates, the level of business activity, real estate prices and the location of the firm in relation to the main regional tourism destinations — that have a significant effect on the probability of having hard-to-fill vacancies and skills shortages.
Poems
Includes Fancy Limes at a Sponging House and The Biographical Fallacies Found in Migration\u27s Anxious Knuckle
Análisis de las diferencias salariales por discapacidad en España: el caso de los varones
El objetivo de este trabajo es estimar las diferencias salariales entre las personas con discapacidad y sin discapacidad en España, descomponiendo tales diferencias entre los factores que más contribuyen a explicarlas. A partir de los microdatos del Panel de Hogares de la Unión Europea para el período 1995-2000, se estiman para una muestra de hombres ecuaciones de salarios para cada colectivo, corregidas por el sesgo de selección a través del método de estimación de dos etapas de Heckman. Los resultados obtenidos muestran que aunque un 57,02 por 100 de la diferencia salarial ofrecida es explicada por las diferencias en las características observadas (especialmente en el nivel educativo y el tipo de ocupación), una parte importante es atribuible a las diferencias en los rendimientos de tales características (42,98 por 100).Discapacidad, discriminación salarial, sesgo de selección
Mercado laboral de las personas discapacitadas en España
En este trabajo, partiendo de un análisis inicial basado en el estudio de las
políticas públicas dirigidas a las personas discapacitadas y de los problemas
en la definición de la discapacidad, se analizan las características sociodemográficas
de las personas discapacitadas en edad de trabajan y aquellas que
están trabajando. A partir de la información disponible en el Panel de Hogares
de la Unión Europea para el año 1998, los resultados obtenidos permiten
afirmar que uno de los principales obstáculos para la integración laboral
de las personas discapacitadas se sitúa en la primera fase del proceso de inserción,
es decir, en pasar de la inactividad a la actividad. Estos resultados
tienen implicaciones en las futuras políticas públicas dirigidas a favorecer la
integración laboral y social de este colectivo.________________________________In this piece of work, beginning with a preliminary analysis of the public policies
for disabled persons and the problems associated to the concept of disability,
we analyse the sociodemographics characteristics of working age and employed
disabled persons in Spain. Using the data from the European Household
Panel for 1998, our results show that the main barrier for the labour integration
of the disabled person is found in the first phase of the process, this
is to say, from the inactivity to labour activity. These results have implication
for the future public policies lead to this specific group
Tabaquismo en la consulta de enfermería de atención primaria
La Sociedad Científica Española de Enfermería –SCELE, ha realizado en la Facultad de Ciencias de la Salud de la Universidad de Alicante, los días 9 y 10 de Junio de 2016, el VIII Congreso Nacional SCELE, bajo el lema: "LIDERAZGO DE ENFERMERÍA EN LA GESTIÓN DE CUIDADOS EN LA CRONICIDAD". Se ofrece el acceso a los Resúmenes de las Comunicaciones Científicas Orales y Posters presentadas y defendidas en el trascurso del mencionado Congreso, en sus distintas categorías: estudios de investigación, proyectos de investigación y casos de cuidados
Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage
Phthiocerol dimycocerosates (PDIMs) are a class of mycobacterial lipids that promote virulence in Mycobacterium tuberculosis and Mycobacterium marinum. It has recently been shown that PDIMs work in concert with the M. tuberculosis Type VII secretion system ESX-1 to permeabilize the phagosomal membranes of infected macrophages. As the zebrafish-M. marinum model of infection has revealed the critical role of PDIM at the host-pathogen interface, we set to determine if PDIMs contributed to phagosomal permeabilization in M. marinum. Using an ΔmmpL7 mutant defective in PDIM transport, we find the PDIM-ESX-1 interaction to be conserved in an M. marinum macrophage infection model. However, we find PDIM and ESX-1 mutants differ in their degree of defect, with the PDIM mutant retaining more membrane damaging activity. Using an in vitro hemolysis assay—a common surrogate for cytolytic activity, we find that PDIM and ESX-1 differ in their contributions: the ESX-1 mutant loses hemolytic activity while PDIM retains it. Our observations confirm the involvement of PDIMs in phagosomal permeabilization in M. marinum infection and suggest that PDIM enhances the membrane disrupting activity of pathogenic mycobacteria and indicates that the role they play in damaging phagosomal and red blood cell membranes may differ
Characterization of spontaneous and evoked activity of mouse embryonic stem cell derived motor neurons using optogenetics and micro electrode array electrophysiology
Thorough characterization of distinct neuronal lineages derived from progenitor cells is essential for the development of biological models that can recreate native function of neurons of the central nervous system while permitting researchers to have an easily accessible source of cellular building blocks. These models are particularly important for studies on neurological disorders aimed at understanding disease pathways and for high throughput testing of drug candidates. Furthermore, developing a model system with stem cell-derived spinal cord motor neurons (MN) is attractive for designing control systems for soft-tissue robotics. The critical first step towards building a useful model with MNs require a detail investigation of spontaneous and stimulation-evoked electrical activity of developing MN networks. The following work uses multi-electrode array (MEA) electrophysiology and optogenetics to characterize electrical activity of MNs differentiated from mouse embryonic stem (mES) cells. A customizable substrate integrated 60-electrode MEA chip was designed for this study. MEA chips were fabricated with platinum deposited on borofloat glass for detection of small changes in electrical field potentials resulting from neuronal activity that causes small change in ionic currents. A Multi-Channel Systems amplifier was used for recording. MN embryoid bodies (MEBs) were grown in these MEA chips, and differentiation of mES cells into MNs was monitored by the expression of eGFP with a MN specific promoter, Hb9. The mES cell line was transfected with channelrhodopsin-2 (ChR2) tagged with Td-Tomato which allowed for optogenetic stimulation of the networks with a 470 nm LED. Network firing patterns were evaluated for bursting activity and spectral content using analysis algorithms developed in MATLAB. Data presented here demonstrated that MEBs are spontaneously active, they develop a robust network synchronization, and optogenetic stimulation increased the firing rate and affected the firing patterns. This work established a model system with mES cell derived MNs. These findings are a milestone in the efforts of developing neural circuits that can be used to potentially control higher order soft-tissue robotics
Formally Defining and Iterating Infinite Models
International audienceThe wide adoption of MDE raises new situations where we need to manipulate very large models or even infinite model streams gathered at runtime. These new uses cases for MDE raise challenges that had been unforeseen by the time standard modeling framework were designed. This paper proposes a formal definition of an infinite model, as well as a formal framework to reason on queries over infinite models. This formal query definition aims at supporting the design and verification of operations that manipulate infinite models. First, we precisely identify the MOF parts which must be refined to support infinite structure. Then, we provide a formal coinductive definition dealing with unbounded and potentially infinite graph-based structure
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