553 research outputs found
Роль количественной магнитно-резонансной томографии и спектроскопии скелетных мышц в оценке результатов клинических исследований (часть II)
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Probing the core structure and evolution of red giants using gravity-dominated mixed modes observed with Kepler
We report for the first time a parametric fit to the pattern of the \ell = 1
mixed modes in red giants, which is a powerful tool to identify
gravity-dominated mixed modes. With these modes, which share the
characteristics of pressure and gravity modes, we are able to probe directly
the helium core and the surrounding shell where hydrogen is burning. We propose
two ways for describing the so-called mode bumping that affects the frequencies
of the mixed modes. Firstly, a phenomenological approach is used to describe
the main features of the mode bumping. Alternatively, a quasi-asymptotic
mixed-mode relation provides a powerful link between seismic observations and
the stellar interior structure. We used period \'echelle diagrams to emphasize
the detection of the gravity-dominated mixed modes. The asymptotic relation for
mixed modes is confirmed. It allows us to measure the gravity-mode period
spacings in more than two hundred red giant stars. The identification of the
gravity-dominated mixed modes allows us to complete the identification of all
major peaks in a red giant oscillation spectrum, with significant consequences
for the true identification of \ell = 3 modes, of \ell = 2 mixed modes, for the
mode widths and amplitudes, and for the \ell = 1 rotational splittings. The
accurate measurement of the gravity-mode period spacing provides an effective
probe of the inner, g-mode cavity. The derived value of the coupling
coefficient between the cavities is different for red giant branch and clump
stars. This provides a probe of the hydrogen-shell burning region that
surrounds the helium core. Core contraction as red giants ascend the red giant
branch can be explored using the variation of the gravity-mode spacing as a
function of the mean large separation.Comment: Accepted in A&
II.2 Description of processes and corrections from observation to delivery
This book is dedicated to all the people interested in the CoRoT mission and the beautiful data that were delivered during its six year duration. Either amateurs, professional, young or senior researchers, they will find treasures not only at the time of this publication but also in the future twenty or thirty years. It presents the data in their final version, explains how they have been obtained, how to handle them, describes the tools necessary to understand them, and where to find them. It also highlights the most striking first results obtained up to now. CoRoT has opened several unexpected directions of research and certainly new ones still to be discovered
Increasing galactose consumption by Saccharomyces cerevisiae through metabolic engineering of the GAL gene regulatory network
Solar-like oscillations with low amplitude in the CoRoT target HD 181906
Context: The F8 star HD 181906 (effective temperature ~6300K) was observed
for 156 days by the CoRoT satellite during the first long run in the centre
direction. Analysis of the data reveals a spectrum of solar-like acoustic
oscillations. However, the faintness of the target (m_v=7.65) means the
signal-to-noise (S/N) in the acoustic modes is quite low, and this low S/N
leads to complications in the analysis. Aims: To extract global variables of
the star as well as key parameters of the p modes observed in the power
spectrum of the lightcurve. Methods: The power spectrum of the lightcurve, a
wavelet transform and spot fitting have been used to obtain the average
rotation rate of the star and its inclination angle. Then, the autocorrelation
of the power spectrum and the power spectrum of the power spectrum were used to
properly determine the large separation. Finally, estimations of the mode
parameters have been done by maximizing the likelihood of a global fit, where
several modes were fit simultaneously. Results: We have been able to infer the
mean surface rotation rate of the star (~4 microHz) with indications of the
presence of surface differential rotation, the large separation of the p modes
(~87 microHz), and therefore also the ridges corresponding to overtones of the
acoustic modes.Comment: Paper Accepted to be published in A&A. 10 Pages, 12 figure
Physics of Solar Prominences: I - Spectral Diagnostics and Non-LTE Modelling
This review paper outlines background information and covers recent advances
made via the analysis of spectra and images of prominence plasma and the
increased sophistication of non-LTE (ie when there is a departure from Local
Thermodynamic Equilibrium) radiative transfer models. We first describe the
spectral inversion techniques that have been used to infer the plasma
parameters important for the general properties of the prominence plasma in
both its cool core and the hotter prominence-corona transition region. We also
review studies devoted to the observation of bulk motions of the prominence
plasma and to the determination of prominence mass. However, a simple inversion
of spectroscopic data usually fails when the lines become optically thick at
certain wavelengths. Therefore, complex non-LTE models become necessary. We
thus present the basics of non-LTE radiative transfer theory and the associated
multi-level radiative transfer problems. The main results of one- and
two-dimensional models of the prominences and their fine-structures are
presented. We then discuss the energy balance in various prominence models.
Finally, we outline the outstanding observational and theoretical questions,
and the directions for future progress in our understanding of solar
prominences.Comment: 96 pages, 37 figures, Space Science Reviews. Some figures may have a
better resolution in the published version. New version reflects minor
changes brought after proof editin
CoRoT photometry and high-resolution spectroscopy of the interacting eclipsing binary AU Mon
Analyses of very accurate CoRoT space photometry, past Johnson V
photoelectric photometry and high-resolution \'echelle spectra led to the
determination of improved and consistent fundamental stellar properties of both
components of AU Mon. We derived new, accurate ephemerides for both the orbital
motion (with a period of 11.113d) and the long-term, overall brightness
variation (with a period of 416.9d) of this strongly interacting Be + G
semi-detached binary. It is shown that this long-term variation must be due to
attenuation of the total light by some variable circumbinary material. We
derived the binary mass ratio = 0.17\p0.03 based on the
assumption that the G-type secondary fills its Roche lobe and rotates
synchronously. Using this value of the mass ratio as well as the radial
velocities of the G-star, we obtained a consistent light curve model and
improved estimates of the stellar masses, radii, luminosities and effective
temperatures. We demonstrate that the observed lines of the B-type primary may
not be of photospheric origin. We also discover rapid and periodic light
changes visible in the high-quality residual CoRoT light curves. AU Mon is put
into perspective by a comparison with known binaries exhibiting long-term
cyclic light changes.Comment: Accepted for publication in MNRA
Predicting the detectability of oscillations in solar-type stars observed by Kepler
Asteroseismology of solar-type stars has an important part to play in the
exoplanet program of the NASA Kepler Mission. Precise and accurate inferences
on the stellar properties that are made possible by the seismic data allow very
tight constraints to be placed on the exoplanetary systems. Here, we outline
how to make an estimate of the detectability of solar-like oscillations in any
given Kepler target, using rough estimates of the temperature and radius, and
the Kepler apparent magnitude.Comment: 21 pages, 6 figures, accepted for publication Astrophysical Journa
Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study
Background Late-onset Pompe disease is characterized by progressive skeletal myopathy followed by respiratory muscle weakness, typically leading to loss of ambulation and respiratory failure. In this population, enzyme replacement therapy (ERT) with alglucosidase alfa has been shown to stabilize respiratory function and improve mobility and muscle strength. Muscle pathology and glycogen clearance from skeletal muscle in treatment-naïve adults after ERT have not been extensively examined. Methods This exploratory, open-label, multicenter study evaluated glycogen clearance in muscle tissue samples collected pre- and post- alglucosidase alfa treatment in treatment-naïve adults with late-onset Pompe disease. The primary endpoint was the quantitative reduction in percent tissue area occupied by glycogen in muscle biopsies from baseline to 6 months. Secondary endpoints included qualitative histologic assessment of tissue glycogen distribution, secondary pathology changes, assessment of magnetic resonance images (MRIs) for intact muscle and fatty replacement, and functional assessments. Results Sixteen patients completed the study. After 6 months of ERT, the percent tissue area occupied by glycogen in quadriceps and deltoid muscles decreased in 10 and 8 patients, respectively. No changes were detected on MRI from baseline to 6 months. A majority of patients showed improvements on functional assessments after 6 months of treatment. All treatment-related adverse events were mild or moderate. Conclusions This exploratory study provides novel insights into the histopathologic effects of ERT in late-onset Pompe disease patients. Ultrastructural examination of muscle biopsies demonstrated reduced lysosomal glycogen after ERT. Findings are consistent with stabilization of disease by ERT in treatment-naïve patients with late-onset Pompe disease
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