Digital holography as 3D tracking tool for assessing acoustophoretic particle manipulation

The integration of digital holography (DH) imaging and the acoustic manipulation of micro-particles in a microfluidic environment is investigated. The ability of DH to provide efficient 3D tracking of particles inside a microfluidic channel is exploited to measure the position of multiple objects moving under the effect of stationary ultrasound pressure fields. The axial displacement provides a direct verification of the numerically computed positions of the standing wave’s node, while the particle’s transversal movement highlights the presence of nodes in the planar direction. Moreover, DH is used to follow the aggregation dynamics of trapped spheres in such nodes by using aggregation rate metrics

Expansión de la soja transgénica y deforestación en la Argentina, 1990-2018

Es objetivo de este trabajo describir y explicar la vinculación existente entre la expansión del cultivo de soja, casi totalmente transgénica desde fines del siglo XX, con la deforestación en nuestro país. La vía metodológica seleccionada es la utilización de información estadística oficial específica, contextualizada en los procesos económicos y sociales en los que se registran esos datos. La soja genéticamente modificada es no sólo la mayor expresión del agronegocio en Argentina, sino también uno de los más controversiales y problemáticos usos del territorio. Las consecuencias ambientales de este modelo son discutidas considerando el área de bosques nativos talada debido a la expansión de la frontera sojera. El poder político y legal opera como garante de la desposesión de indígenas y campesinos por medio de las órdenes de desalojo y aceptando como legítima la documentación falsificada de las empresas. Los cercamientos silenciosos y estrategias de violencia abierta han sido complementados por la deforestación. Cerca de 5 millones de hectáreas de bosques nativos fueron derribadas en exactamente 16 años (1998-2014). El avance de la soja fue el mayor impulso de la reducción del área con bosques entre 2002 y 2011, tanto directa como indirectamente. Notablemente, el 95,8del área desmontada (4.754.747 hectáreas) implica tanto al área núcleo de la soja como a las regiones periféricas recientemente conquistadas por la sojización. En suma, la producción de soja causa deforestación, pérdida de biodiversidad, exportación libre de suelo y agua virtual, desertificación, etc.Evento realizado junto con el VII Congreso Nacional de Geografía de Universidades PúblicasFacultad de Humanidades y Ciencias de la Educació

Heavy metals in canned tuna from Italian markets.

Fish is a good source of nutrients for humans but can pose a risk to human health because of the possible presence of some xenobiotics such as heavy metals and persistent organic contaminants. Constant monitoring is needed to minimize health risks and ensure product quality and consumer safety. The aim of the present study was to use atomic absorption spectrometry to determine the concentrations of some heavy metals (Hg, Pb, and Cd) in tuna packaged in different kinds of packages (cans or glass) in various countries (Italy and elsewhere). Concentrations of Cd and Hg were within the limits set by European Commission Regulation (EC) No 1881/2006 and in many samples were below the detection limit. Pb concentrations exceeded European limits in 9.8% of the analyzed samples. These results are reassuring in terms of food safety but highlighted the need to constantly monitor the concentrations of heavy metals in fish products that could endanger consumer health

Cancer risk in oil refinery workers : a pooled mortality study in Italy

Background: Oil refinery workers are exposed to several well-established carcinogens and working in this type of industry has been classified by IARC as probable carcinogen to humans (Group 2A). Objectives: To examine the mortality experience of workers employed in four Italian oil refineries. Methods: The cohort included 5112 male workers ever employed between 1949 and 2011. The average follow-up period was 49 years. Standardized mortality ratios (SMR) and 95% Confidence Intervals (CI) were calculated using as reference age-gender-calendar specific regional rates. Analyses by duration of employment and latency were performed. Results: In the whole cohort, pleural cancer (6 deaths, SMR 1.59; 95% CI 0.71-3.53), brain cancer (14 deaths, SMR 1.47; 95% CI 0.87-2.49) and lymphatic leukemia (LL) (8 deaths, SMR 1.81; 95% CI 0.91-3.62) showed increased risks. All pleural cancers occurred after 10 years of latency and the highest risk was observed among workers with duration 6520 years; the brain cancer excess was confined in the shortest duration and latency. The LL (and chronic lymphatic leukemia in particular) excess regarded workers with latency and duration longer than 20 years. Four deaths from acute myeloid leukemia (AML) were observed and all occurred after 20 years of latency (SMR 1.55, 95% CI 0.58-4.12); a two-fold-increased risk was observed in the longest duration. No increased risk for skin cancer has been observed in our study population. Conclusion: Our findings are consistent with recent evidence of an increased mortality from pleural and hematopoietic malignancies (AML and LL) among oil refinery workers. However, the lack of individual quantitative exposure data and the small number of observed events prevent the identification of the possible causal role of individual chemicals, including benzene, especially at the current very low exposure levels

A Semi-Lagrangian scheme for a modified version of the Hughes model for pedestrian flow

In this paper we present a Semi-Lagrangian scheme for a regularized version of the Hughes model for pedestrian flow. Hughes originally proposed a coupled nonlinear PDE system describing the evolution of a large pedestrian group trying to exit a domain as fast as possible. The original model corresponds to a system of a conservation law for the pedestrian density and an Eikonal equation to determine the weighted distance to the exit. We consider this model in presence of small diffusion and discuss the numerical analysis of the proposed Semi-Lagrangian scheme. Furthermore we illustrate the effect of small diffusion on the exit time with various numerical experiments

Rejection of mismatched disturbances for systems with input delay via a predictive extended state observer

[EN] The problem of output stabilization and disturbance rejection for input-delayed systems is tackled in this work. First, a suitable transformation is introduced to translate mismatched disturbances into an equivalent input disturbance. Then, an extended state observer is combined with a predictive observer structure to obtain a future estimation of both the state and the disturbance. A disturbance model is assumed to be known but attenuation of unmodeled components is also considered. The stabilization is proved via Lyapunov-Krasovskii functionals, leading to sufficient conditions in terms of linear matrix inequalities for the closed-loop analysis and parameter tuning. The proposed strategy is illustrated through a numerical example.PROMETEOII/2013/004; Conselleria d'Educacio; Generalitat Valenciana, Grant/Award Number: TIN2014-56158-C4-4-P-AR; Ministerio de Economia y Competitividad, Grant/Award Number: FPI-UPV 2014; Universitat Politecnica de ValenciaSanz Diaz, R.; García Gil, PJ.; Fridman, E.; Albertos Pérez, P. (2018). Rejection of mismatched disturbances for systems with input delay via a predictive extended state observer. International Journal of Robust and Nonlinear Control. 28(6):2457-2467. https://doi.org/10.1002/rnc.4027S24572467286Stability and Stabilization of Systems with Time Delay. (2011). IEEE Control Systems, 31(1), 38-65. doi:10.1109/mcs.2010.939135Fridman, E. (2014). Introduction to Time-Delay Systems. Systems & Control: Foundations & Applications. doi:10.1007/978-3-319-09393-2Watanabe, K., & Ito, M. (1981). A process-model control for linear systems with delay. 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IEEE Transactions on Automatic Control, 24(4), 541-552. doi:10.1109/tac.1979.1102124Artstein, Z. (1982). Linear systems with delayed controls: A reduction. IEEE Transactions on Automatic Control, 27(4), 869-879. doi:10.1109/tac.1982.1103023Krstic, M. (2008). Lyapunov tools for predictor feedbacks for delay systems: Inverse optimality and robustness to delay mismatch. Automatica, 44(11), 2930-2935. doi:10.1016/j.automatica.2008.04.010Léchappé, V., Moulay, E., Plestan, F., Glumineau, A., & Chriette, A. (2015). New predictive scheme for the control of LTI systems with input delay and unknown disturbances. Automatica, 52, 179-184. doi:10.1016/j.automatica.2014.11.003Sanz, R., Garcia, P., & Albertos, P. (2016). Enhanced disturbance rejection for a predictor-based control of LTI systems with input delay. Automatica, 72, 205-208. doi:10.1016/j.automatica.2016.05.019Basturk, H. I., & Krstic, M. (2015). Adaptive sinusoidal disturbance cancellation for unknown LTI systems despite input delay. Automatica, 58, 131-138. doi:10.1016/j.automatica.2015.05.013Basturk, H. I. (2017). Cancellation of unmatched biased sinusoidal disturbances for unknown LTI systems in the presence of state delay. Automatica, 76, 169-176. doi:10.1016/j.automatica.2016.10.006Sanz, R., Garcia, P., Albertos, P., & Zhong, Q.-C. (2016). Robust controller design for input-delayed systems using predictive feedback and an uncertainty estimator. International Journal of Robust and Nonlinear Control, 27(10), 1826-1840. doi:10.1002/rnc.3639Mondie, S., & Michiels, W. (2003). Finite spectrum assignment of unstable time-delay systems with a safe implementation. IEEE Transactions on Automatic Control, 48(12), 2207-2212. doi:10.1109/tac.2003.820147Zhong, Q.-C. (2004). On Distributed Delay in Linear Control Laws—Part I: Discrete-Delay Implementations. IEEE Transactions on Automatic Control, 49(11), 2074-2080. doi:10.1109/tac.2004.837531Zhou, B., Lin, Z., & Duan, G.-R. (2012). Truncated predictor feedback for linear systems with long time-varying input delays. Automatica, 48(10), 2387-2399. doi:10.1016/j.automatica.2012.06.032Zhou, B., Li, Z.-Y., & Lin, Z. (2013). On higher-order truncated predictor feedback for linear systems with input delay. International Journal of Robust and Nonlinear Control, 24(17), 2609-2627. doi:10.1002/rnc.3012Besançon G Georges D Benayache Z Asymptotic state prediction for continuous-time systems with delayed input and application to control IEEE 2007 Kos, GreeceNajafi, M., Hosseinnia, S., Sheikholeslam, F., & Karimadini, M. (2013). Closed-loop control of dead time systems via sequential sub-predictors. International Journal of Control, 86(4), 599-609. doi:10.1080/00207179.2012.751627Léchappé V Moulay E Plestan F Dynamic observation-prediction for LTI systems with a time-varying delay in the input IEEE 2016 Las Vegas, NVCacace, F., Conte, F., Germani, A., & Pepe, P. (2016). 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Pathophysiology, diagnosis and treatment of somatosensory tinnitus: a scoping review

Somatosensory tinnitus is a generally agreed subtype of tinnitus that is associated with activation of the somatosensory, somatomotor, and visual-motor systems. A key characteristic of somatosensory tinnitus is that is modulated by physical contact or movement. Although it seems common, its pathophysiology, assessment and treatment are not well defined. We present a scoping review on the pathophysiology, diagnosis, and treatment of somatosensory tinnitus, and identify priority directions for further research. Methods: Literature searches were conducted in Google Scholar, PubMed, and EMBASE databases. Additional broad hand searches were conducted with the additional terms etiology, diagnose, treatment. Results: Most evidence on the pathophysiology of somatosensory tinnitus suggests that somatic modulations are the result of altered or cross-modal synaptic activity within the dorsal cochlear nucleus or between the auditory nervous system and other sensory subsystems of central nervous system (e.g., visual or tactile). Presentations of somatosensory tinnitus are varied and evidence for the various approaches to treatment promising but limited. Discussion and Conclusions: Despite the apparent prevalence of somatosensory tinnitus its underlying neural processes are still not well understood. Necessary involvement of multidisciplinary teams in its diagnosis and treatment has led to a large heterogeneity of approaches whereby tinnitus improvement is often only a secondary effect. Hence there are no evidence-based clinical guidelines, and patient care is empirical rather than research-evidence-based. Somatic testing should receive further attention considering the breath of evidence on the ability of patients to modulate their tinnitus through manouvers. Specific questions for further research and review are indicated

Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A₄ Mimetics (QNX-sLXms)

Failure to resolve inflammation underlies many prevalent pathologies. Recent insights have identified lipid mediators, typified by lipoxins (LXs), as drivers of inflammation resolution, suggesting potential therapeutic benefit. We report the asymmetric preparation of novel quinoxaline-containing synthetic-LXA4-mimetics (QNX-sLXms). Eight novel compounds were screened for their impact on inflammatory responses. Structure–activity relationship (SAR) studies showed that (R)-6 (also referred to as AT-02-CT) was the most efficacious and potent anti-inflammatory compound of those tested. (R)-6 significantly attenuated lipopolysaccharide (LPS)- and tumor-necrosis-factor-α (TNF-α)-induced NF-κB activity in monocytes and vascular smooth muscle cells. The molecular target of (R)-6 was investigated. (R)-6 activated the endogenous LX receptor formyl peptide receptor 2 (ALX/FPR2). The anti-inflammatory properties of (R)-6 were further investigated in vivo in murine models of acute inflammation. Consistent with in vitro observations, (R)-6 attenuated inflammatory responses. These results support the therapeutic potential of the lead QNX-sLXm (R)-6 in the context of novel inflammatory regulators