Boys don’t cry: Trauma, trauma narrative and masculine practice among young male who engaged in harmful sexual behaviour

Compelling evidence suggests that majority of young men who engaged in harmful sexual behaviour (HSB) were subjected to various forms of trauma and adverse childhood experiences. This research explores lived experience of a group of young men who engaged in HSB, what sense they made of it and how their positioned themselves towards these events including HSB, so they are able to maintain their self-integrity. It also explores impact of lived experience with consideration for broader family and cultural discourses. Transition to Adulthood Attachment Interview and Semi-structured interview were employed and Dynamic- Maturation Model of attachment were utilised for this research since it differentiates for dismissed and pre-occupied trauma spectrums. Findings highlighted that all of the young men presented mainly with complex unresolved dismissed trauma or loss and some with both types of trauma. Furthermore, they employed dominant hegemonic culturally shared discourses of masculinity to make sense of their lived experience. The ways in which experiences of trauma shaped the HSB pathway that developed is discussed. </jats:p

New Magellanic Cloud R Coronae Borealis and DY Per type stars from the EROS-2 database: the connection between RCBs, DYPers and ordinary carbon stars

R Coronae Borealis stars (RCB) are a rare type of evolved carbon-rich supergiant stars that are increasingly thought to result from the merger of two white dwarfs, called the Double degenerate scenario. This scenario is also studied as a source, at higher mass, of type Ia Supernovae (SnIa) explosions. Therefore a better understanding of RCBs composition would help to constrain simulations of such events. We searched for and studied RCB stars in the EROS Magellanic Clouds database. We also extended our research to DY Per type stars (DYPers) that are expected to be cooler RCBs (T~3500 K) and much more numerous than their hotter counterparts. The light curves of ~70 millions stars have been analysed to search for the main signature of RCBs and DYPers: a large drop in luminosity. Follow-up optical spectroscopy was used to confirm each photometric candidate found. We have discovered and confirmed 6 new Magellanic Cloud RCB stars and 7 new DYPers, but also listed new candidates: 3 RCBs and 14 DYPers. We estimated a range of Magellanic RCB shell temperatures between 360 and 600 K. We confirm the wide range of absolute luminosity known for RCB stars, M_V~-5.2 to -2.6. Our study further shows that mid-infrared surveys are ideal to search for RCB stars, since they have thinner and cooler circumstellar shells than classical post-AGB stars. In addition, by increasing the number of known DYPers by ~400%, we have been able to shed light on the similarities in the spectral energy distribution between DYPers and ordinary carbon stars. We also observed that DYPer circumstellar shells are fainter and hotter than those of RCBs. This suggests that DYPers may simply be ordinary carbon stars with ejection events, but more abundance analysis is necessary to give a status on a possible evolutionnary connexion between RCBs and DYPers.Comment: 22 pages, 38 figures, Accepted for publication in A&

Regression discontinuity analysis demonstrated varied effect of Treat-All on CD4 testing among Southern African countries

OBJECTIVE: To determine whether Treat-All policy impacted laboratory testing practices of antiretroviral therapy (ART) programs in Southern Africa.STUDY DESIGN AND SETTING: We used HIV cohort data from Lesotho, Malawi, Mozambique, South Africa, Zambia and Zimbabwe in a regression discontinuity design to estimate changes in pre-ART CD4 testing and viral load monitoring following national Treat-all adoption that occurred during 2016-2017. This study included more than 230,000 ART-naïve people living with HIV (PLHIV) aged five years or older who started ART within two years of national Treat-All adoption.RESULTS: We found pre-ART CD4 testing decreased following adoption of Treat-All recommendations in Malawi (-21.4 percentage points (pp), 95% CI: -26.8, -16.0) and in Mozambique (-8.8pp, 95% CI: -14.9, -2.8), but increased in Zambia (+2.7pp, 95% CI: +0.4, +5.1). Treat-All policy had no effect on viral load monitoring, except among females in South Africa (+7.1pp, 95% CI: +1.1, +13.0).CONCLUSION: Treat-All policy expanded ART eligibility, but led to reductions in pre-ART CD4 testing in some countries that may weaken advanced HIV disease management. Continued and expanded support of CD4 and viral load laboratory capacity is needed to further improve treatment successes and allow for uniform evaluation of ART implementation across Southern Africa.</p

R Coronae Borealis stars in the Galactic Bulge discovered by EROS-2

Rare types of variable star may give unique insight into short-lived stages of stellar evolution. The systematic monitoring of millions of stars and advanced light curve analysis techniques of microlensing surveys make them ideal for discovering also such rare variable stars. One example is the R Coronae Borealis (RCB) stars, a rare type of evolved carbon-rich supergiant. We have conducted a systematic search of the EROS-2 database for the Galactic catalogue Bulge and spiral arms to find Galactic RCB stars. The light curves of $\sim$100 million stars, monitored for 6.7 years (from July 1996 to February 2003), have been analysed to search for the main signature of RCB stars, large and rapid drops in luminosity. Follow-up spectroscopy has been used to confirm the photometric candidates. We have discovered 14 new RCB stars, all in the direction of the Galactic Bulge, bringing the total number of confirmed Galactic RCB stars to about 51. After reddening correction, the colours and absolute magnitudes of at least 9 of the stars are similar to those of Magellanic RCB stars. This suggests that these stars are in fact located in the Galactic Bulge, making them the first RCB stars discovered in the Bulge. The localisation of the 5 remaining RCBs is more uncertain: 4 are either located behind the Bulge at an estimated maximum distance of 14 kpc or have an unusual thick circumstellar shell; the other is a DY Per RCB which may be located in the Bulge, even if it is fainter than the known Magellanic DY Per. From the small scale height found using the 9 new Bulge RCBs, $61<h^{RCB}_{Bulge}<246$ pc (95% C.L.), we conclude that the RCB stars follow a disk-like distribution inside the Bulge.Comment: 20 pages, 26 figures, Accepted in A&

Eu-Social Science: The Role of Internet Social Networks in the Collection of Bee Biodiversity Data

Background Monitoring change in species diversity, community composition and phenology is vital to assess the impacts of anthropogenic activity and natural change. However, monitoring by trained scientists is time consuming and expensive. Methodology/Principal Findings Using social networks, we assess whether it is possible to obtain accurate data on bee distribution across the UK from photographic records submitted by untrained members of the public, and if these data are in sufficient quantity for ecological studies. We used Flickr and Facebook as social networks and Flickr for the storage of photographs and associated data on date, time and location linked to them. Within six weeks, the number of pictures uploaded to the Flickr BeeID group exceeded 200. Geographic coverage was excellent; the distribution of photographs covered most of the British Isles, from the south coast of England to the Highlands of Scotland. However, only 59% of photographs were properly uploaded according to instructions, with vital information such as ‘tags’ or location information missing from the remainder. Nevertheless, this incorporation of information on location of photographs was much higher than general usage on Flickr (∼13%), indicating the need for dedicated projects to collect spatial ecological data. Furthermore, we found identification of bees is not possible from all photographs, especially those excluding lower abdomen detail. This suggests that giving details regarding specific anatomical features to include on photographs would be useful to maximise success. Conclusions/Significance The study demonstrates the power of social network sites to generate public interest in a project and details the advantages of using a group within an existing popular social network site over a traditional (specifically-designed) web-based or paper-based submission process. Some advantages include the ability to network with other individuals or groups with similar interests, and thus increasing the size of the dataset and participation in the project

An anatomy-based lumped parameter model of cerebrospinal venous circulation: can an extracranial anatomical change impact intracranial hemodynamics?

Background The relationship between extracranial venous system abnormalities and central nervous system disorders has been recently theorized. In this paper we delve into this hypothesis by modeling the venous drainage in brain and spinal column areas and simulating the intracranial flow changes due to extracranial morphological stenoses. Methods A lumped parameter model of the cerebro-spinal venous drainage was created based on anatomical knowledge and vessels diameters and lengths taken from literature. Each vein was modeled as a hydraulic resistance, calculated through Poiseuille’s law. The inputs of the model were arterial flow rates of the intracranial, vertebral and lumbar districts. The effects of the obstruction of the main venous outflows were simulated. A database comprising 112 Multiple Sclerosis patients (Male/Female = 42/70; median age ± standard deviation = 43.7 ± 10.5 years) was retrospectively analyzed. Results The flow rate of the main veins estimated with the model was similar to the measures of 21 healthy controls (Male/Female = 10/11; mean age ± standard deviation = 31 ± 11 years), obtained with a 1.5 T Magnetic Resonance scanner. The intracranial reflux topography predicted with the model in cases of internal jugular vein diameter reduction was similar to those observed in the patients with internal jugular vein obstacles. Conclusions The proposed model can predict physiological and pathological behaviors with good fidelity. Despite the simplifications introduced in cerebrospinal venous circulation modeling, the key anatomical feature of the lumped parameter model allowed for a detailed analysis of the consequences of extracranial venous impairments on intracranial pressure and hemodynamics

Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis.

Venous abnormalities contribute to the pathophysiology of several neurological conditions. This paper reviews the literature regarding venous abnormalities in multiple sclerosis (MS), leukoaraiosis, and normal-pressure hydrocephalus (NPH). The review is supplemented with hydrodynamic analysis to assess the effects on cerebrospinal fluid (CSF) dynamics and cerebral blood flow (CBF) of venous hypertension in general, and chronic cerebrospinal venous insufficiency (CCSVI) in particular.CCSVI-like venous anomalies seem unlikely to account for reduced CBF in patients with MS, thus other mechanisms must be at work, which increase the hydraulic resistance of the cerebral vascular bed in MS. Similarly, hydrodynamic changes appear to be responsible for reduced CBF in leukoaraiosis. The hydrodynamic properties of the periventricular veins make these vessels particularly vulnerable to ischemia and plaque formation.Venous hypertension in the dural sinuses can alter intracranial compliance. Consequently, venous hypertension may change the CSF dynamics, affecting the intracranial windkessel mechanism. MS and NPH appear to share some similar characteristics, with both conditions exhibiting increased CSF pulsatility in the aqueduct of Sylvius.CCSVI appears to be a real phenomenon associated with MS, which causes venous hypertension in the dural sinuses. However, the role of CCSVI in the pathophysiology of MS remains unclear

Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms