351 research outputs found

    Nanomedicines – Ensuring Patient Safety through Regulatory Clarity

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    Extreme relativistic electron fluxes at geosynchronous orbit: Analysis of GOES E > 2 MeV electrons

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    Relativistic electrons (E > 1 MeV) cause internal charging on satellites and are an important space weather hazard. A key requirement in space weather research concerns extreme events and knowledge of the largest flux expected to be encountered over the lifetime of a satellite mission. This is interesting both from a scientific and practical point of view since satellite operators, engineers and the insurance industry need this information to better evaluate the effects of extreme events on their spacecraft. Here we conduct an extreme value analysis of daily averaged E > 2 MeV electron fluxes from the Geostationary Operational Environmental Satellites (GOES) during the 19.5 year period from 1 January 1995 to 30 June 2014. We find that the daily averaged flux measured at GOES West is typically a factor of ~2.5 higher than that measured at GOES East and we conduct independent analyses for these two locations. The 1 in 10, 1 in 50 and 1 in 100 year daily averaged E > 2 MeVelectron fluxes at GOES West are 1.84×105, 5.00×105 and 7.68×105 cm−2s−1sr−1 respectively. The corresponding fluxes at GOES East are 6.53×104, 1.98×105 and 3.25×105 cm−2s−1sr−1 respectively. The largest fluxes seen during the 19.5 year period on 29 July 2004 were particularly extreme and were seen by satellites at GOES West and GOES East. The extreme value analysis suggests that this event was a 1 in 50 year event

    Congenital cataract associated with persistent fetal vasculature: findings from IoLunder2

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    PURPOSE: To describe the frequency, characteristics, and treatment outcome of persistent fetal vasculature (PFV) in children undergoing surgery for congenital and infantile cataract in the first 2 years of life. PATIENTS AND METHODS: Observational population-based cohort study with case identification through active surveillance and standardised data collection via a national clinical network, the British Isles Congenital Cataract Interest Group (BCCIG). RESULTS: The IoLunder2 cohort comprises 246 children undergoing surgery for bilateral and unilateral congenital and infantile cataract in the first 2 years of life. A total of 58/246 (24%) children had PFV (%): overall, 46/95 (46%) with unilateral cataract, and 12/141 (8%) with bilateral disease. Anterior segment vascular remnants were more common in bilateral than unilateral disease (75 vs 11%, P=0.01). At 1 year after surgery, 20% of children with bilateral PFV and 24% with unilateral had achieved normal vision for age within the operated eye. The prevalence of post-operative glaucoma was 9% (of children with bilateral disease) and 4% (unilateral). CONCLUSION: PFV is significantly more common than previously reported, and outcomes are comparable to that for congenital and infantile cataract overall

    Extreme internal charging currents in medium Earth orbit: Analysis of SURF plate currents on Giove-A

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    Relativistic electrons can penetrate spacecraft shielding and can damage satellite components. Spacecraft in medium Earth orbit pass through the heart of the outer radiation belt and may be exposed to large fluxes of relativistic electrons, particularly during extreme space weather events. In this study we perform an extreme value analysis of the daily average internal charging currents at three different shielding depths in medium Earth orbit as a function of L∗ and along the orbit path. We use data from the SURF instrument on board the European Space Agency's Giove-A spacecraft from December 2005 to January 2016. The top, middle, and bottom plates of this instrument respond to electrons with energies >500 keV, >700 keV, and >1.1 MeV, respectively. The 1 in 10 year daily average top plate current decreases with increasing L∗ ranging from 1.0 pA cm−2 at L∗=4.75 to 0.03 pA cm−2 at L∗=7.0. The 1 in 100 year daily average top plate current is a factor of 1.2 to 1.8 larger than the corresponding 1 in 10 year current. The 1 in 10 year daily average middle and bottom plate currents also decrease with increasing L∗ ranging from 0.4 pA cm−2 at L∗=4.75 to 0.01 pA cm−2 at L∗=7.0. The 1 in 100 year daily average middle and bottom plate currents are a factor of 1.2 to 2.7 larger than the corresponding 1 in 10 year currents. Averaged along the orbit path the 1 in 10 year daily average top, middle, and bottom plate currents are 0.22, 0.094, and 0.094 pA cm−2, respectively

    Observations of red-giant variable stars by Aboriginal Australians

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    Aboriginal Australians carefully observe the properties and positions of stars, including both overt and subtle changes in their brightness, for subsistence and social application. These observations are encoded in oral tradition. I examine two Aboriginal oral traditions from South Australia that describe the periodic changing brightness in three pulsating, red-giant variable stars: Betelgeuse (Alpha Orionis), Aldebaran (Alpha Tauri), and Antares (Alpha Scorpii). The Australian Aboriginal accounts stand as the only known descriptions of pulsating variable stars in any Indigenous oral tradition in the world. Researchers examining these oral traditions over the last century, including anthropologists and astronomers, missed the description of these stars as being variable in nature as the ethnographic record contained several misidentifications of stars and celestial objects. Arguably, ethnographers working on Indigenous Knowledge Systems should have academic training in both the natural and social sciences.Comment: The Australian Journal of Anthropology (2018

    The most plausible explanation of the cyclical period changes in close binaries: the case of the RS CVn-type binary WW Dra

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    We searched the orbital period changes in 182 EA-type (including the 101 Algol systems used by \cite{hal89}), 43 EB-type and 53 EW-type binaries with known both the mass ratio and the spectral type of their secondary components. We reproduced and improved the same diagram as Hall's (1989) according to the new collected data. Our plots do not support the conclusion derived by \cite{hal89} that all cases of cyclical period changes are restricted to binaries having the secondary component with spectral types later than F5. The presence of period changes also among stars with secondary component of early type indicates that the magnetic activity is one cause, but not the only one, for the period variation. It is discovered that cyclic period changes, likely due to the presence of a third body are more frequent in EW-type binaries among close binaries. Therefore, the most plausible explanation of the cyclical period changes is the LTTE via the presence of a third body. By using the century-long historical record of the times of light minimum, we analyzed the cyclical period change in the Algol binary WW Dra. It is found that the orbital period of the binary shows a ∼112.2yr\sim112.2 \textbf{\textrm{yr}} cyclic variation with an amplitude of ∼0.1977days\sim0.1977\textbf{\textrm{days}}. The cyclic oscillation can be attributed to the LTTE via a third body with a mass no less than 6.43M⊙6.43 M_{\odot}. However, no spectral lines of the third body were discovered indicating that it may be a candidate black hole. The third body is orbiting the binary at a distance shorter than 14.4 AU and it may play an important role in the evolution of this system.Comment: 9 pages, 5 figures, published by MNRA

    Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

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    Imprinted genes, defined by their preferential expression of a single parental allele, represent a subset of the mammalian genome and often have key roles in embryonic development1, but also postnatal functions including energy homeostasis2 and behaviour3, 4. When the two parental alleles are unequally represented within a social group (when there is sex bias in dispersal and/or variance in reproductive success)5, 6, imprinted genes may evolve to modulate social behaviour, although so far no such instance is known. Predominantly expressed from the maternal allele during embryogenesis, Grb10 encodes an intracellular adaptor protein that can interact with several receptor tyrosine kinases and downstream signalling molecules7. Here we demonstrate that within the brain Grb10 is expressed from the paternal allele from fetal life into adulthood and that ablation of this expression engenders increased social dominance specifically among other aspects of social behaviour, a finding supported by the observed increase in allogrooming by paternal Grb10-deficient animals. Grb10 is, therefore, the first example of an imprinted gene that regulates social behaviour. It is also currently alone in exhibiting imprinted expression from each of the parental alleles in a tissue-specific manner, as loss of the peripherally expressed maternal allele leads to significant fetal and placental overgrowth. Thus Grb10 is, so far, a unique imprinted gene, able to influence distinct physiological processes, fetal growth and adult behaviour, owing to actions of the two parental alleles in different tissues

    Four-colour photometry of eclipsing binaries. XLI uvby light curves for AD Bootis, HW Canis Majoris, SW Canis Majoris, V636 Centauri, VZ Hydrae, and WZ Ophiuchi

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    CONTEXT: Accurate mass, radius, and abundance determinations from binaries provide important information on stellar evolution, fundamental to central fields in modern astrophysics and cosmology. AIMS: Within the long-term Copenhagen Binary Project, we aim to obtain high-quality light curves and standard photometry for double-lined detached eclipsing binaries with late A, F, and G type main-sequence components, needed for the determination of accurate absolute dimensions and abundances, and for detailed comparisons with results from recent stellar evolutionary models. METHODS: Between March 1985 and July 2007, we carried out photometric observations of AD Boo, HW CMA, SW CMa, V636 Cen, VZ Hya, and WZ Oph at the Str"omgren Automatic Telescope at ESO, La Silla. RESULTS: We obtained complete uvby light curves, ephemerides, and standard uvby\beta indices for all six systems.For V636 Cen and HW CMa, we present the first modern light curves, whereas for AD Boo, SW CMa, VZ Hya, and WZ Oph, they are both more accurate and more complete than earlier data. Due to a high orbital eccentricity (e = 0.50), combined with a low orbital inclination (i = 84.7), only one eclipse, close to periastron, occurs for HW CMa. For the two other eccentric systems, V636 Cen (e = 0.134) and SW CMa (e = 0.316), apsidal motion has been detected with periods of 5270 +/- 335 and 14900 +/- 3600 years, respectively.Comment: Only change is: Bottom lines (hopefully) not truncated anymore. Accepted for publication in Astonomy & Astrophysic
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