Buxton, J

Egan, B

Isles, M

Koutnik, A

McClure, T

Plank, E

Prins, P

English

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         Multisystem Regulatory Capacity of Exogenous Ketone Administration at Rest Emma Plank1, Tyler S. McClure2,3, Jeffery D. Buxton1, Brendan Egan2,3, McKenna Isles1, Andrew P. Koutnik3,4, Phillip Prins1. 1Grove City College, Grove City, PA, 2Dublin City University, Dublin, Ireland, 3Institute for Human and Machine Cognition, Pensacola, FL, USA, 4Sansum Diabetes Research Institute, Santa Barbara, CA, USA. Acute ingestion of exogenous ketone supplements (EKS) in the form of a (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (R-BD R-βHB) ketone monoester (KME) has demonstrated the ability to alter metabolism and acid/base balance at rest. PURPOSE: To explore how a variety of new, yet unstudied, forms of commercially-available EKS modulate metabolism and acid/base balance pharmacokinetics at rest. METHODS: Utilizing a single-blind, placebo-controlled, randomized crossover design, twenty healthy participants (M: 10, F:10; age: 20.6±2.0 y, height: 171.7±7.5 cm, weight: 67.9±10.2 kg) visited the laboratory on 5 separate occasions, comprising one familiarization and four main experimental sessions with ≥7-day wash-out period between experimental sessions. The four main experimental sessions (visits 2 to 5) consisted of metabolic, cardiac (autonomic & hemodynamic), blood gases (acid-base & gas exchange) and cognitive evaluation at rest measured at various time points. The visits differed only in the randomly assigned drink consumed, which included various EKS (395 mg/kg), namely KME, KME+sodium bicarbonate (KME+BIC), and a non-racemic ketone salt (KS), and were compared to a non-caloric taste-matched placebo (PLA). RESULTS: All EKS significantly increased blood R-βHB concentration (30 min, KME: 2.6±0.7 mM; KME+BIC: 3.2±0.9 mM; KS: 1.5±0.4 mM; all p<0.001) and reduced blood glucose concentration (30 min, KME: -15.8±14.7 mg/dL, p<0.01; KS: -11.6±10.3 mg/dL, p<0.05) compared to PLA. KME ingestion decreased pH (-0.04±0.03, p<0.001), whereas KS (60 min, 0.03±0.03, p<0.05) and KME+BIC (120 min, 0.05±0.05, p<0.001) increased pH compared to PLA. Cognitive performance during the Stroop color word test and switching task did not differ at any time point within or between conditions (all p>0.05). CONCLUSION: Exogenous ketosis produced by the ingestion of KS or KME alone (~2-4 mM) does not affect indirect calorimetry, HRV, hemodynamics, or cognition at rest in young healthy males and females. KME+BIC increased the degree of ketosis (~0.5 mM), altered HRV, and increased pH. The non-racemic KS produced a more rapid and higher peak blood ketone concentration compared to previous work in racemic KS, suggesting that such formulations warrant further investigations. SIGNIFANCE/NOVELTY: A novel finding is that a non-racemic KS increased blood R-βHB concentration >2.0 mM. This finding warrants future work into comparing KME and non-racemic KS at similar concentrations of EKs to elucidate any further differences or best application for either exogenous ketone source. Supported by Grove City College Swezey Fund  Mid Atlantic Regional Chapter of the American College of Sports Medicine  46th Annual Scientific Meeting, November 3rd - 4th, 2023 Conference Proceedings International Journal of Exercise Science, Issue 9, Volume 12 

Multisystem Regulatory Capacity of Exogenous Ketone Administration at Rest

https://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=8022&context=ijesab

Multisystem Regulatory Capacity of Exogenous Ketone Administration at Rest

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