SU(2) vortex configuration in Laplacian Center Gauge

We study how Laplacian Center Gauge identifies the vortex content of a thick SU(2) vortex configuration on the lattice. This configuration is a solution of the Yang-Mills classical equations of motion having vortex properties. We find that this gauge fixing procedure cleanly identifies the underlying vortex properties. We also study the monopole content of this configuration detected with this procedure. We obtain two monopole curves lying on the surface of the vortex.Comment: 22 pages, 10 PostScript figures. v2, 21 pages, 10 Postscript figures. Part of the results and part of the conclusions change in v2. v3, 13 pages, 4 Postscript figures, shortened version to appear in PL

Vortex configurations in the large N limit

We study the properties of vortex-like configurations which are solutions of the SU(N) Yang-Mills classical equations of motion. We show that these solutions are concentrated along a two-dimensional wall with size growing with the number of colors.Comment: 13 pages, 4 postscript figure

Monopole and vortex content of a meron pair

We investigate the monopole and vortex content of a meron pair by calculating the points at which the transformation to the Laplacian Center Gauge is ill-defined and by studying the behavior of Wilson loops. These techniques reveal complementary aspects of the vortex and monopole structure, including the presence of closed monopole lines and closed vortex surfaces joining the two merons, and evidence for intersecting vortex surfaces at each meron.Comment: 14 pages, 5 figures. v2, minor changes, references added, to appear in PL

eCONSULTA: Integración de un Sistema de Videoconsultoría Web entre Asistencia Primaria y Atención Especializada

En este artículo presentamos un sistema de videoconferencia web de bajo coste cuyo objetivo es mejorar la comunicación entre Atención Primaria y Atención Especializada optimizando los recursos y la calidad de la atención en enfermedades con alta prevalencia en la actualidad. En este caso se utiliza para problemas metabólicos como la diabetes o patologías del tiroides, aunque podría ser aplicado a otras patologías. El sistema está basado en una herramienta de SW libre (OpenMeetings) adaptada a nuestras necesidades y a la que se han añadido funcionalidades importantes como una sala de espera virtual o la administración de agendas. eCONSULTA ha sido instalado en el Servicio de Endocrinología y Nutrición del Hospital de Sabadell e integrado en el sistema de información médico de los Centros de Atención Primaria de la comarca del Vallés Occidental, provincia de Barcelona. En el momento de la redacción del artículo se está realizando un estudio de viabilidad y satisfacción de los usuarios

Sex Differences and Predictors of In-Hospital Mortality among Patients with COVID-19: Results from the ANCOHVID Multicentre Study

Spain is one of the countries most affected by the COVID-19 pandemic. Although risk factors for severe disease are published, sex differences have been widely neglected. In this multicentre study, we aimed to identify predictors of in-hospital mortality in men and women hospitalised with COVID-19. An observational longitudinal study was conducted in the cohort of patients admitted to four hospitals in Andalusia, Spain, from 1 March 2020 to 15 April 2020. Sociodemographic and clinical data were collected from hospital records. The Kaplan–Meier method was used to estimate 30-day survival and multiple Cox regression models were applied. All analyses were stratified by sex. A total of 968 patients were included (54.8% men, median age 67.0 years). In-hospital mortality reached 19.1% in men and 16.0% in women. Factors independently associated with an increased hazard of death were advanced age, higher CURB-65 score and not receiving azithromycin treatment, in both sexes; active cancer and autoimmune disease, in men; cardiovascular disease and chronic lung disease, in women. Disease outcomes and predictors of death differed between sexes. In-hospital mortality was higher in men, but the long-term effects of COVID-19 merit further research. The sex-differential impact of the pandemic should be addressed in public health policies

Influence of Drilling Technique on the Radiographic, Thermographic, and Geomorphometric Effects of Dental Implant Drills and Osteotomy Site Preparations

The aim of this comparative study is to analyze the influence of drilling technique on the radiographic, thermographic, and geomorphometric e ects of dental implant drills and osteotomy site preparations. One hundred and twenty osteotomy site preparations were performed on sixty epoxy resin samples using three unused dental implant drill systems and four drilling techniques performed with a random distribution into the following study groups: Group A: drilling technique performed at 800 rpm with irrigation (n = 30); Group B: drilling technique performed at 45 rpm without irrigation (n = 30); Group C: drilling technique performed at 45 rpm with irrigation (n = 30); and Group D: drilling technique performed at 800 rpm without irrigation (n = 30). The osteotomy site preparation morphologies performed by the 4.1 mm diameter dental implant drills from each study group were analyzed and compared using a cone beam computed tomography (CBCT) scan. The termographic e ects generated by the 4.1 mm diameter dental implant drills from each study group were registered using a termographic digital camera and the unused and 4.1 mm diameter dental implant drills that were used 30 times from each study group were exposed to a micro computed tomography (micro-CT) analysis to obtain a Standard Tessellation Language (STL) digital files that determined the wear comparison by geomorphometry. Statistically significant di erences were observed between the thermographic and radiographic results of the study groups (p < 0.001). The e ect of cooling significatively reduced the heat generation during osteotomy site preparation during high-speed drilling; furthermore, osteotomy site preparation was not a ected by the wear of the dental implant drills after 30 uses, regardless of the drilling technique.Odontologí

La gran estafa de la "producción académica"

Editorial de presentación del Volumen 3 número 1 de Márgenes, Revista de Educación de la Universidad de Málaga. Séptimo número de la revista, compuesto por un total de 17 textos, distribuidos en las diferentes secciones. Se trata de un número de carácter ecléctico en el que continuamos ofreciendo contenidos fieles a las premisas y los pilares educativos con los que partíamos

An Epilepsy-Causing Mutation Leads to Co-Translational Misfolding of the Kv7.2 Channel

BACKGROUND: The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. Such consideration is particularly relevant in human diseases associated to inherited mutations leading to structural instability, aggregation, and degradation. Mutations in the KCNQ2 gene associated with human epilepsy have been suggested to cause misfolding of the encoded Kv7.2 channel. Although the effect on folding of mutations in some domains has been studied, little is known of the way pathogenic variants located in the calcium responsive domain (CRD) affect folding. Here, we explore how a Kv7.2 mutation (W344R) located in helix A of the CRD and associated with hereditary epilepsy interferes with channel function. RESULTS: We report that the epilepsy W344R mutation within the IQ motif of CRD decreases channel function, but contrary to other mutations at this site, it does not impair the interaction with Calmodulin (CaM) in vitro, as monitored by multiple in vitro binding assays. We find negligible impact of the mutation on the structure of the complex by molecular dynamic computations. In silico studies revealed two orientations of the side chain, which are differentially populated by WT and W344R variants. Binding to CaM is impaired when the mutated protein is produced in cellulo but not in vitro, suggesting that this mutation impedes proper folding during translation within the cell by forcing the nascent chain to follow a folding route that leads to a non-native configuration, and thereby generating non-functional ion channels that fail to traffic to proper neuronal compartments. CONCLUSIONS: Our data suggest that the key pathogenic mechanism of Kv7.2 W344R mutation involves the failure to adopt a configuration that can be recognized by CaM in vivo but not in vitroThe Government of the Autonomous Community of the Basque Country (IT1165-19 and KK-2020/00110) and the Spanish Ministry of Science and Innovation (RTI2018-097839-B-100 to A.V. and FIS2016-76617-P to A.B.) and FEDER funds and the US National Institute of Neurological Disorders (NINDS) and Stroke Research Project Grant (R01NS083402 to H.J.C.) provided financial support for this work. E.N. and A.M-M. are supported by predoctoral contracts from the Basque Government administered by University of the Basque Country. C.M. was supported by the Basque Government through a Basque Excellence Research Centre (BERC) grant administered by Fundación Biofisika Bizkaia (FBB). J.U. was partially supported by BERC funds. O.R.B. was supported by the Basque Government through a BERC grant administered by Donostia International Physics Center. J.Z. and H.J.C. was supported by the NINDS Research Project Grant #R01NS083402 (PI: H.J.C.)

Analysis of multipactor RF breakdown in a waveguide containing a transversely magnetized ferrite

In this paper, the multipactor RF breakdown in a parallel-plate waveguide partially filled with a ferrite slab magnetized normal to the metallic plates is studied. An external magnetic field is applied along the vertical direction between the plates in order to magnetize the ferrite. Numerical simulations using an in-house 3D code are carried out to obtain the multipactor RF voltage threshold in this kind of structures. The presented results show that the multipactor RF voltage threshold at certain frequencies becomes considerably lower than for the corresponding classical metallic parallel-plate waveguide with the same vacuum gap.This work was supported by the European Space Agency (ESA) under Novel Investigation in Multipactor Effect in Ferrite and other Dielectrics used in high power RF Space Hardware Contract AO 1-7551/13/NL/GLC, and partially by the Spanish Government (under coordinated R&D projects TEC2013-47037-C5-R and TEC2014-55463-C3-3-P)