18 research outputs found
Evaluación multidisciplinar 3D de una estructura kárstica asociada a colapso y subsidencia (Cuenca del Ebro)
La propagación de cavidades de disolución localizadas por debajo de series aluviales genera una serie de evidencias cuya representación superficial, en ocasiones, puede no ser indicativa de su extensión real en profundidad.
La propagación de cavidades a través de medios heterogéneos, en los que pueden existir niveles cementados, puede producir cambios en la progresión de dichas cavidades y la identificación en superficie de grietas, colapsos, o zonas de subsidencia que pueden involucrar decenas de miles de metros cúbicos de material inestable. Cualquier tipo de evaluación de soluciones mitigadoras en estos contextos debe considerar la amplitud de estos volúmenes y el origen del proceso con independencia de la actividad registrada en superficie. En este trabajo se aborda un estudio integrado con el objetivo de determinar la estructura de un sector con evidencias de actividad kárstica superficial y evaluar su extensión y desarrollo tridimensional integrando el análisis geomorfológico, de inspección de campo, geofísica (GPR) y sondeos.
The propagation of solution cavities located below alluvial deposits produce surficial evidences that, in some cases, cannot be representative of their actual extension at depth. Cavity propagation through heterogeneous media, for example with interbedded cemented levels, can produce changes in the propagation of deformation producing the identification of cracks, collapses or subsidence zones at the surface. These processes can involve thousands of cubic meters of unstable materials. Any evaluation of mitigation tasks, in this context, needs to consider: i) the amplitude of the affected volumes and ii) the in depth origin with independence of the surficial recorded activity In this work an integrated analysis is developed to evaluate the size and 3D structure of a sector with surficial evidences of karstic activity integrating geomorphological analysis, field inspection, geophysics (GPR) and boreholes
Tratado de derechos reales. Tomo II Propiedad y posesión
La presente investigación está referida
al análisis de los dos principales
derechos reales: la posesión
y la propiedad, y es la continuación de
la investigación concluida denominada
Tratado de derechos reales, tomo I, teoría
de los bienes y los derechos reales.
Esta parte de la investigación corresponde
al desarrollo de dos de sus principales
instituciones. Así, se comienza
con el análisis sociojurídico de la posesión
(poder hecho) como derecho transitorio
(temporal y momentáneo), para
luego entrar al desarrollo de la propiedad
(poder de derecho) como derecho
definitivo (permanente y total), ambas
instituciones reconocidas como situaciones
jurídicas de gran trascendencia
en las relaciones jurídicas patrimoniales,
protegidas por la ley a través de
mecanismos de defensa
Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry
Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%
Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMEDPlus study
Background: This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults.
Methods: This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55-75 years, BMI 27-40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults.
Results: Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05).
Conclusions: Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health
Evaluation of image guided radiotherapy (IGRT) in lung cancer. Is weekly cone beam CT (CBCT) enough?
On the tectonic origin of Iberian topography
The present-day topography of the Iberian peninsula can be considered as the result of the MesozoicCenozo–ic
tectonic evolution of the Iberian plate (including rifting and basin formation during the Mesozoic and
compression and mountain building processes at the borders and inner part of the plate, during the Tertiary,
followed by Neogene rifting on the Mediterranean side) and surface processes acting during the Quaternary.
The northern-central part of Iberia (corresponding to the geological units of the Duero Basin, the Iberian Chain,
and the Central System) shows a mean elevation close to one thousand meters above sea level in average, some
hundreds of meters higher than the southern half of the Iberian plate. This elevated area corresponds to (i) the
top of sedimentation in Tertiary terrestrial endorheic sedimentary basins (Paleogene and Neogene) and
(ii) planation surfaces developed on Paleozoic and Mesozoic rocks of the mountain chains surrounding the
Tertiary sedimentary basins. Both types of surfaces can be found in continuity along the margins of some of the
Tertiary basins. The Bouguer anomaly map of the Iberian peninsula indicates negative anomalies related to
thickening of the continental crust. Correlations of elevation to crustal thickness and elevation to Bouguer
anomalies indicate that the dierent landscape units within the Iberian plate can be ascribed to dierent
patterns: (1) The negative Bouguer anomaly in the Iberian plate shows a rough correlation with elevation, the
most important gravity anomalies being linked to the Iberian Chain. (2) Most part of the so-called Iberian
Meseta is linked to intermediate-elevation areas with crustal thickening; this pattern can be applied to the two
main intraplate mountain chains (Iberian Chain and Central System) (3) The main mountain chains (Pyrenees
and Betics) show a direct correlation between crustal thickness and elevation, with higher elevation/crustal
thickness ratio for the Central Systemvs. the Betics and the Pyrenees. Other features of the Iberian topography,
namely the longitudinal pro le of the main rivers in the Iberian peninsula and the distribution of present-day
endorheic areas, are consistent with the Tertiary tectonic evolution and the change from an endorheic to an
exorheic regime during the Late Neogene and the Quaternary. Some of the problems involving the timing and
development of the Iberian Meseta can be analysed considering the youngest reference level, constituted by
the shallow marine Upper Cretaceous limestones, that indicates strong dierences induced by (i) the overall
Tertiary and recent compression in the Iberian plate, responsible for dierences in elevation of the reference
level of more than 6 km between the mountain chains and the endorheic basins and (ii) the eect of Neogene
extension in the Mediterranean margin, responsible for lowering several thousands of meters toward the East
and uplift of rift shoulders. A part of the recent uplift within the Iberian plate can be attributed o sostatic uplift in zones of crustal thickening