UNBOUND

Featured here, are the extraordinary works of our graduating Fashion Design class. This accomplishment is truly a celebration of the tree years of passion, hard work, and dedication of our students. It\u27s our hope that the fashion industry will partake in the creative endeavors of the emerging designers from the Fashion Design program at Fanshawe College in London, Ontario.https://first.fanshawec.ca/famd_design_fashiondesign_unbound/1002/thumbnail.jp

An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map. We used this map to derive a quantitative sepsis response signature (SRSq) score reflective of immune dysfunction and predictive of clinical outcomes, which can be estimated using a 7- or 12-gene signature. Last, we built a machine learning framework, SepstratifieR, to deploy SRSq in adult and pediatric bacterial and viral sepsis, H1N1 influenza, and COVID-19, demonstrating clinically relevant stratification across diseases and revealing some of the physiological alterations linking immune dysregulation to mortality. Our method enables early identification of individuals with dysfunctional immune profiles, bringing us closer to precision medicine in infection.peer-reviewe

Symposium abstracts: Pace, penalty and pirouette: the sociology of physical culture

Pace, penalty and pirouette: the sociology of physical culture was an event organised and hosted by PhD students Victoria Palmer (Glasgow Caledonian University) and Bethany Whiteside (Royal Conservatoire of Scotland). Funded by the British Sociological Association as a Postgraduate Regional Event, the day was primarily designed to be a supportive platform for postgraduate students from across Scotland and further afield to unite, discuss, present, and share their research with academics with similar interests. The event focused on aspects of ‘physical culture’, attracting scholars from several areas of study including dance, leisure studies, outdoor activity, physical activity, physical education, physical theatre, outdoor activity and sport. Broadly speaking, those who study physical culture are interested in the ways in which individuals engage in (or do not engage in) physical practices and how these individuals are affected by, or influence their social and cultural environment.Publisher PD