Etude de faisabilité d'un projet d'appui aux unités de conservation de la faune au Burkina Faso. Document final et proposition de projet

Dans le cadre de la réforme de la gestion des ressources naturelles, le Burkina Faso innove avec le concept d'Unité de Conservation de la Faune. Les zones de chasse et les parcs nationaux amodiés au secteur privé doivent contribuer au développement local, subvenir en partie à leurs propres besoins de gestion pour soulager les finances publiques et conserver durablement la biodiversité en la valorisant par différents modes de tourisme : vision, grande chasse, petite chasse. Cette approche devrait être appuyée par un projet de la coopération bilatérale France/Burkina Faso au travers de l'Agence Française de Développement et au Fonds Français pour l'Environnement Mondial. Le présent document étudie la faisabilité de ce projet. Il fait suite à mon premier document dans lequel était présentée une étude détaillée du contrat. (Résumé d'auteur

Securing land and resource rights in Africa: Pan-African perspectives

Across the African continent the land and resource rights of the rural poor are threatened by inappropriate policies and institutions (including global treaties); unequal social, political and economic relations; the actions of powerful vested interests (wealthy national or local elites, international aid organisations, multinational corporations); and the weakness of grassroots organisations. It is against this background that the Pan-African Programme on Land and Resource Rights (PAPLRR) Network’s initiative to analyse, understand and engage with these issues was conceptualised by four African centres of excellence that subsequently developed the programme in 2001. The unique contributions Africa can make are seldom taken seriously in international natural resource policymaking debates. One reason could be that the African voice on land and resource rights is perhaps not as strong in international forums as it should be. By coming together in forums such as PAPLRR, Africans are able to share their concerns and develop capacity to articulate their opinions and influence outcomes in the international arena. Defining an agenda for advocacy and strategic engagement with governments, and building links across divides between scholars, practitioners and advocacy groups, is an emphasis of PAPLRR into the future. A key focus of the programme is the role of land and resource rights in the struggle against poverty, exploitation and oppression as well as their contribution in solving real world problems of African people, not as academic objects to be studied, but as key components of the struggle

The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria : a meta-analysis of individual patient data

Background: Artesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria. Methods: Individual patient data from AS-AQ clinical trials were pooled using the WorldWide Antimalarial Resistance Network (WWARN) standardised methodology. Risk factors for treatment failure were identified using a Cox regression model with shared frailty across study sites. Results: Forty-three studies representing 9,106 treatments from 1999-2012 were included in the analysis; 4,138 (45.4%) treatments were with a fixed dose combination with an AQ target dose of 30 mg/kg (FDC), 1,293 (14.2%) with a non-fixed dose combination with an AQ target dose of 25 mg/kg (loose NFDC-25), 2,418 (26.6%) with a non-fixed dose combination with an AQ target dose of 30 mg/kg (loose NFDC-30), and the remaining 1,257 (13.8%) with a co-blistered non-fixed dose combination with an AQ target dose of 30 mg/kg (co-blistered NFDC). The median dose of AQ administered was 32.1 mg/kg [IQR: 25.9-38.2], the highest dose being administered to patients treated with co-blistered NFDC (median = 35.3 mg/kg [IQR: 30.6-43.7]) and the lowest to those treated with loose NFDC-25 (median = 25.0 mg/kg [IQR: 22.7-25.0]). Patients treated with FDC received a median dose of 32.4 mg/kg [IQR: 27-39.0]. After adjusting for reinfections, the corrected antimalarial efficacy on day 28 after treatment was similar for co-blistered NFDC (97.9% [95% confidence interval (CI): 97.0-98.8%]) and FDC (98.1% [95% CI: 97.6%-98.5%]; P = 0.799), but significantly lower for the loose NFDC-25 (93.4% [95% CI: 91.9%-94.9%]), and loose NFDC-30 (95.0% [95% CI: 94.1%-95.9%]) (P < 0.001 for all comparisons). After controlling for age, AQ dose, baseline parasitemia and region; treatment with loose NFDC-25 was associated with a 3.5-fold greater risk of recrudescence by day 28 (adjusted hazard ratio, AHR = 3.51 [95% CI: 2.02-6.12], P < 0.001) compared to FDC, and treatment with loose NFDC-30 was associated with a higher risk of recrudescence at only three sites. Conclusions: There was substantial variation in the total dose of amodiaquine administered in different AS-AQ combination regimens. Fixed dose AS-AQ combinations ensure optimal dosing and provide higher antimalarial treatment efficacy than the loose individual tablets in all age categories