8 research outputs found
Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making
For nanotechnology to meet its potential as a game-changing and sustainable technology, it is important to ensure that the engineered nanomaterials and nanoenabled products that gain entry to the marketplace are safe and effective. Tools and methods are needed for regulatory purposes to allow rapid material categorization according to human health and environmental risk potential, so that materials of high concern can be targeted for additional scrutiny, while material categories that pose the least risk can receive expedited review. Using carbon nanotubes as an example, we discuss how data from alternative testing strategies can be used to facilitate engineered nanomaterial categorization according to risk potential and how such an approach could facilitate regulatory decision-making in the future
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Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making.
For nanotechnology to meet its potential as a game-changing and sustainable technology, it is important to ensure that the engineered nanomaterials and nanoenabled products that gain entry to the marketplace are safe and effective. Tools and methods are needed for regulatory purposes to allow rapid material categorization according to human health and environmental risk potential, so that materials of high concern can be targeted for additional scrutiny, while material categories that pose the least risk can receive expedited review. Using carbon nanotubes as an example, we discuss how data from alternative testing strategies can be used to facilitate engineered nanomaterial categorization according to risk potential and how such an approach could facilitate regulatory decision-making in the future
Harmonizing across environmental nanomaterial testing media for increased comparability of nanomaterial datasets
The chemical composition and properties of environmental media determine nanomaterial (NM)
transport, fate, biouptake, and organism response. To compare and interpret experimental data, it is
essential that sufficient context be provided for describing the physical and chemical characteristics of
the setting in which a nanomaterial may be present. While the nanomaterial environmental, health and
safety (NanoEHS) field has begun harmonization to allow data comparison and re-use (e.g. using
standardized materials, defining a minimum set of required material characterizations), there is limited
guidance for standardizing test media. Since most of the NM properties driving environmental behaviour
and toxicity are medium-dependent, harmonization of media is critical. A workshop in March 2016 at
Duke University identified five categories of test media: aquatic testing media, soil and sediment testing
media, biological testing media, engineered systems testing media and product matrix testing media.
For each category of test media, a minimum set of medium characteristics to report in all NM tests is
recommended. Definitions and detail level of the recommendations for specific standardized media vary
across these media categories. This reflects the variation in the maturity of their use as a test medium
and associated measurement techniques, variation in utility and relevance of standardizing medium
properties, ability to simplify standardizing reporting requirements, and in the availability of established
standard reference media. Adoption of these media harmonization recommendations will facilitate the
generation of integrated comparable datasets on NM fate and effects. This will in turn allow testing of
the predictive utility of functional assay measurements on NMs in relevant media, support investigation
of first principles approaches to understand behavioral mechanisms, and support categorization
strategies to guide research, commercial development, and policy.publishe
Nanomaterial Categorization for Assessing Risk Potential To Facilitate Regulatory Decision-Making
NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment
Nanotechnology has enabled the discovery of a multitude of novel materials exhibiting unique physicochemical (PChem) properties compared to their bulk analogues. These properties have led to a rapidly increasing range of commercial applications; this, however, may come at a cost, if an association to long-term health and environmental risks is discovered or even just perceived. Many nanomaterials (NMs) have not yet had their potential adverse biological effects fully assessed, due to costs and time constraints associated with the experimental assessment, frequently involving animals. Here, the available NM libraries are analyzed for their suitability for integration with novel nanoinformatics approaches and for the development of NM specific Integrated Approaches to Testing and Assessment (IATA) for human and environmental risk assessment, all within the NanoSolveIT cloud-platform. These established and well-characterized NM libraries (e.g. NanoMILE, NanoSolutions, NANoREG, NanoFASE, caLIBRAte, NanoTEST and the Nanomaterial Registry (>2000 NMs)) contain physicochemical characterization data as well as data for several relevant biological endpoints, assessed in part using harmonized Organisation for Economic Co-operation and Development (OECD) methods and test guidelines. Integration of such extensive NM information sources with the latest nanoinformatics methods will allow NanoSolveIT to model the relationships between NM structure (morphology), properties and their adverse effects and to predict the effects of other NMs for which less data is available. The project specifically addresses the needs of regulatory agencies and industry to effectively and rapidly evaluate the exposure, NM hazard and risk from nanomaterials and nano-enabled products, enabling implementation of computational ‘safe-by-design’ approaches to facilitate NM commercialization