Early changes in alpha band power and DMN BOLD activity in Alzheimer's disease: a simultaneous resting state EEG-fMRI study

Simultaneous resting state functional magnetic resonance imaging (rsfMRI)-resting state electroencephalography (rsEEG) studies in healthy adults showed robust positive associations of signal power in the alpha band with BOLD signal in the thalamus, and more heterogeneous associations in cortical default mode network (DMN) regions. Negative associations were found in occipital regions. In Alzheimer's disease (AD), rsfMRI studies revealed a disruption of the DMN, while rsEEG studies consistently reported a reduced power within the alpha band. The present study is the first to employ simultaneous rsfMRI-rsEEG in an AD sample, investigating the association of alpha band power and BOLD signal, compared to healthy controls (HC). We hypothesized to find reduced positive associations in DMN regions and reduced negative associations in occipital regions in the AD group. Simultaneous resting state fMRI-EEG was recorded in 14 patients with mild AD and 14 HC, matched for age and gender. Power within the EEG alpha band (8-12 Hz, 8-10 Hz, and 10-12 Hz) was computed from occipital electrodes and served as regressor in voxel-wise linear regression analyses, to assess the association with the BOLD signal. Compared to HC, the AD group showed significantly decreased positive associations between BOLD signal and occipital alpha band power in clusters in the superior, middle and inferior frontal cortex, inferior temporal lobe and thalamus (p < 0.01, uncorr., cluster size ≥ 50 voxels). This group effect was more pronounced in the upper alpha sub-band, compared to the lower alpha sub-band. Notably, we observed a high inter-individual heterogeneity. Negative associations were only reduced in the lower alpha range in the hippocampus, putamen and cerebellum. The present study gives first insights into the relationship of resting-state EEG and fMRI characteristics in an AD sample. The results suggest that positive associations between alpha band power and BOLD signal in numerous regions, including DMN regions, are diminished in AD

Resonance modes in a 1D medium with two purely resistive boundaries: calculation methods, orthogonality and completeness

Studying the problem of wave propagation in media with resistive boundaries can be made by searching for "resonance modes" or free oscillations regimes. In the present article, a simple case is investigated, which allows one to enlighten the respective interest of different, classical methods, some of them being rather delicate. This case is the 1D propagation in a homogeneous medium having two purely resistive terminations, the calculation of the Green function being done without any approximation using three methods. The first one is the straightforward use of the closed-form solution in the frequency domain and the residue calculus. Then the method of separation of variables (space and time) leads to a solution depending on the initial conditions. The question of the orthogonality and completeness of the complex-valued resonance modes is investigated, leading to the expression of a particular scalar product. The last method is the expansion in biorthogonal modes in the frequency domain, the modes having eigenfrequencies depending on the frequency. Results of the three methods generalize or/and correct some results already existing in the literature, and exhibit the particular difficulty of the treatment of the constant mode

Noise Characteristics of a Four-Jet Impingement Device Inside a Broadband Engine Noise Simulator

The noise generation mechanisms for four directly impinging supersonic jets are investigated employing implicit large eddy simulations with a higher-order accurate weighted essentially non-oscillatory shock-capturing scheme. Impinging jet devices are often used as an experimental apparatus to emulate a broadband noise source. Although such devices have been used in many experiments, a detailed investigation of the noise generation mechanisms has not been conducted before. Thus, the underlying physical mechanisms that are responsible for the generation of sound waves are not well understood. The flow field is highly complex and contains a wide range of temporal and spatial scales relevant for noise generation. Proper orthogonal decomposition of the flow field is utilized to characterize the unsteady nature of the flow field involving unsteady shock oscillations, large coherent turbulent flow structures, and the sporadic appearance of vortex tubes in the center of the impingement region. The causality method based on Lighthill's acoustic analogy is applied to link fluctuations of flow quantities inside the source region to the acoustic pressure in the far field. It will be demonstrated that the entropy fluctuation term in the Lighthill's stress tensor plays a vital role in the noise generation process. Consequently, the understanding of the noise generation mechanisms is employed to develop a reduced-order linear acoustic model of the four-jet impingement device. Finally, three linear acoustic FJID models are used as broadband noise sources inside an engine nacelle and the acoustic scattering results are validated against far-field acoustic experimental data

A galaxy cluster in the innermost Zone of Avoidance, close to the radio phoenix VLSS J2217.5+5943

Context. Galaxy clusters grow via mergers with other clusters and groups. Extended regions of diffuse radio emission with a steep radio spectral index are thought to be indicators of such merger events. Extended radio sources with a significantly curved spectrum and a complex morphology have been found in several galaxy clusters. It has been proposed that these so-called radio phoenices are witnesses of cluster mergers and of the presence of active galactic nuclei prior to the merger. Shock fronts or turbulence induced by the mergers are believed to reenergize plasma emitted in the past active phase of a galaxy. Aims. The steep spectrum radio source VLSS J2217.5+5943 shows a complex filamentary morphology and a curved spectrum. Therefore, the source has previously been classified as a radio phoenix. However, no galaxy cluster associated with this radio source had confidently been detected until now because the source is located in the direction of the innermost zone of the Galactic plane at b = +2.4°, the innermost Zone of Avoidance (ZoA). The main aim of this work is to identify galaxies that are part of a cluster at the location of VLSS J2217.5+5943, determine their redshifts, and analyze their connection with the radio source. The confirmation of a cluster would corroborate the classification of the radio source as a radio phoenix and demonstrate that extended, diffuse radio sources are useful indicators of the presence of a galaxy cluster, in particular in the innermost ZoA. Methods. We analyzed archival observations in the near infrared and mid infrared (Spitzer) to select the galaxies in the immediate neighborhood of the radio source. A sample of 23 galaxies were selected as candidate cluster members. Furthermore, we carried out deep integral field spectroscopy covering 6450 to 10 500 Å with the red unit of the Hobby-Eberly Telescope second generation low resolution spectrograph (LRS2-R). We also reanalyzed archival GMRT observations at 325 and 610 MHz. Results. We selected 23 galaxies within a radius of 2.5 arcmin, centered on RA = 22$^h$17$^m$​.5, Dec = +59° 43′ (J2000). Spectra were obtained for three of the brightest galaxies. For two galaxies we derived redshifts of z = 0.165 and z = 0.161, based on NaD absorption and TiO band heads. Their spectra correspond to E-type galaxies. Both galaxies are spatially associated with VLSS J2217.5+5943. The spectrum of the third galaxy, which is slightly farther from the radio source, indicates a LINER spectral type at z = 0.042. It is apparently a foreground galaxy with respect to the cluster we identified. Conclusions. VLSS J2217.5+5943 is associated with a massive galaxy cluster at redshift z = 0.163 ± .003, supporting its classification as a radio phoenix. The intrinsic properties of the radio source, computed for the cluster redshift, are in good agreement with those of other known radio phoenices. The identification of the galaxy cluster demonstrates that far-red spectroscopy with LRS2-R succeeds in determining the redshift of galaxies in the innermost ZoA. Moreover, it confirms that radio sources can be useful indicators of the presence of galaxy clusters in the ZoA

Changing-look NLS1 galaxies, their detection with SVOM, and the case of NGC 1566

We discuss applications of the study of the new and barely explored class of changing-look (CL) narrow-line Seyfert 1 (NLS1) galaxies and comment on their detection with the space mission SVOM (Space Variable Objects Monitor). We highlight the case of NGC 1566, which is outstanding in many respects, for instance as one of the nearest known CL AGN undergoing exceptional outbursts. Its NLS1 nature is discussed, and we take it as a nearby prototype for systems that could be discovered and studied in the near future, including with SVOM. Finally, we briefly examine the broader implications and applications of CL events in NLS1 galaxies and show that such systems, once discovered in larger numbers, will greatly advance our understanding of the physics of the environment of rapidly growing supermassive black holes. This White Paper is part of a sequence of publications which explore aspects of our understanding of (CL) NLS1 galaxy physics with future missions.Comment: 14 pages, 4 figures. Accepted for publication in the Universe Special Issue "A Multimessenger View of Supermassive Black Holes and the Quasar Main Sequence

Engineering Support Systems for Industrial Machines and Plants

In the business of industrial machines and plants, rapid and detailed estimates for planning installation, replacement of equipment, or maintenance work are key requirements for meeting the demands for greater reliability, lower costs and for maintaining safe and secure operation. These demands have been addressed by developing technology driven by IT. When replacing equipment at complex building or plants with high equipment density, the existing state of the installation locations and transportation routes for old and new equipment need to be properly measured. We have met this need by developing parts recognition technology based on 3D measurement, and by developing high-speed calculation technology of optimal routes for installation parts. This chapter provides an overview of these development projects with some real business application results

Whole-genome sequencing reveals two prolonged simultaneous outbreaks involving Pseudomonas aeruginosa high-risk strains ST111 and ST235 with resistance to quaternary ammonium compounds

Objective Water-bearing systems are known as frequent Pseudomonas aeruginosa (PA) outbreak sources. However, many older buildings continue to have sanitary facilities in high-risk departments such as the ICU. We present two simultaneous prolonged multi-drug-resistant (MDR) PA outbreaks detected at the ICU of a pulmonology hospital, which were resolved by whole-genome sequencing (WGS). Methods Outbreak management and investigations were initiated in August 2019 after detecting two patients with nosocomial VIM-2-positive MDR PA. The investigations involved weekly patient screenings for four months and extensive environmental sampling for 15 months. All patient and environmental isolates were collected and analysed by WGS. Results From April to September 2019, we identified 10 patients with nosocomial MDR PA, including five VIM-2-positive strains. VIM-2-positive strains were also detected in nine sink drains, two toilets, and a cleaning bucket. WGS revealed that of 16 VIM-2-positive isolates, 14 were ST111 that carried qacE, or qacEΔ1 genes, whereas 13 isolates clustered (difference of ≤11 alleles by cgMLST). OXA-2 (two toilets), and OXA-2, OXA-74, PER-1 (two patients, three toilets) qacEΔ1-positive ST235 isolates dominated among VIM-2-negative isolates. The remaining seven PA strains were ST17, ST233, ST273, ST309 and ST446. Outbreak containment was achieved by replacing U-bends, and cleaning buckets, and switching from quaternary ammonium compounds (QUATs) to oxygen-releasing disinfectant products. Conclusion Comprehension and management of two simultaneous MDR PA outbreaks involving the high-risk strains ST111 and ST235 were facilitated by precise control due to identification of different outbreak sources per strain, and by the in-silico detection of high-level QUATs resistance in all isolates

ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases

The objective of this document was to standardise published cardiopulmonary exercise testing (CPET) protocols for improved interpretation in clinical settings and multicentre research projects. This document: 1) summarises the protocols and procedures used in published studies focusing on incremental CPET in chronic lung conditions; 2) presents standard incremental protocols for CPET on a stationary cycle ergometer and a treadmill; and 3) provides patients’ perspectives on CPET obtained through an online survey supported by the European Lung Foundation. We systematically reviewed published studies obtained from EMBASE, Medline, Scopus, Web of Science and the Cochrane Library from inception to January 2017. Of 7914 identified studies, 595 studies with 26 523 subjects were included. The literature supports a test protocol with a resting phase lasting at least 3 min, a 3-min unloaded phase, and an 8- to 12-min incremental phase with work rate increased linearly at least every minute, followed by a recovery phase of at least 2–3 min. Patients responding to the survey (n=295) perceived CPET as highly beneficial for their diagnostic assessment and informed the Task Force consensus. Future research should focus on the individualised estimation of optimal work rate increments across different lung diseases, and the collection of robust normative data.The document facilitates standardisation of conducting, reporting and interpreting cardiopulmonary exercise tests in chronic lung diseases for comparison of reference data, multi-centre studies and assessment of interventional efficacy. http://bit.ly/31SXeB

A self-adaptive segmentation method for a point cloud

The segmentation of a point cloud is one of the key technologies for three-dimensional reconstruction, and the segmentation from three-dimensional views can facilitate reverse engineering. In this paper, we propose a self-adaptive segmentation algorithm, which can address challenges related to the region-growing algorithm, such as inconsistent or excessive segmentation. Our algorithm consists of two main steps: automatic selection of seed points according to extracted features and segmentation of the points using an improved region-growing algorithm. The benefits of our approach are the ability to select seed points without user intervention and the reduction of the influence of noise. We demonstrate the robustness and effectiveness of our algorithm on different point cloud models and the results show that the segmentation accuracy rate achieves 96%

UV photochemistry of the L-cystine disulfide bridge in aqueous solution investigated by femtosecond X-ray absorption spectroscopy

The photolysis of disulfide bonds is implicated in denaturation of proteins exposed to ultraviolet light. Despite this biological relevance in stabilizing the structure of many proteins, the mechanisms of disulfide photolysis are still contested after decades of research. Herein, we report new insight into the photochemistry of L-cystine in aqueous solution by femtosecond X-ray absorption spectroscopy at the sulfur K-edge. We observe homolytic bond cleavage upon ultraviolet irradiation and the formation of thiyl radicals as the single primary photoproduct. Ultrafast thiyl decay due to geminate recombination proceeds at a quantum yield of >80 % within 20 ps. These dynamics coincide with the emergence of a secondary product, attributed to the generation of perthiyl radicals. From these findings, we suggest a mechanism of perthiyl radical generation from a vibrationally excited parent molecule that asymmetrically fragments along a carbon-sulfur bond. Our results point toward a dynamic photostability of the disulfide bridge in condensed-phase