21 research outputs found
First flight of the ATMOS instrument during the Spacelab 3 Mission, April 29 through May 6, 1985
The underlying rationale and the implementation of the Atmospheric Trace Molecule Spectroscopy (ATMOS) investigation are discussed, a description of the sensor is given, and the ground tests and integration procedures leading to the Spacelab 3 flight are described. The data reduction and analysis procedures used after the flight are discussed, a number of examples of the spectra obtained are shown, and the concentration profiles as a function of altitude for the minor and trace gases measured during the mission are presented. On the basis of the instrument's ability to survive both the launch and the reentry of the shuttle and its flawless performance while on orbit, the concepts involved in the investigation have been proved by the Spacelab 3 flight, and an extended series of reflights is currently being planned as a part of the Atmospheric Laboratory for Applications and Science (ATLAS) Missions. The goals for the investigation during these missions are also discussed
Ultraviolet stellar astronomy
The author has identified the following significant results. During all three Skylab missions, prism-on observations were obtained in 188 starfields and prism-off observations in 31 starfields. In general, the fields are concentrated in the Milky Way where the frequency of hot stars is highest. These fields cover an area approximately 3660 degrees and include roughly 24 percent of a band 30 deg wide centered on the plane of the Milky Way. A census of stars in the prism-on fields shows that nearly 6,000 stars have measurable flux data at a wavelength of 2600A, that 1,600 have measurable data at 2000A, and that 400 show useful data at 1500A. Obvious absorption or emission features shortward of 2000A are visible in approximately 120 stars. This represents a bonanza of data useful for statistical studies of stellar classification and of interstellar reddening as well as for studies of various types of peculiar stars
UV and EUV Instruments
We describe telescopes and instruments that were developed and used for
astronomical research in the ultraviolet (UV) and extreme ultraviolet (EUV)
regions of the electromagnetic spectrum. The wavelength ranges covered by these
bands are not uniquely defined. We use the following convention here: The EUV
and UV span the regions ~100-912 and 912-3000 Angstroem respectively. The
limitation between both ranges is a natural choice, because the hydrogen Lyman
absorption edge is located at 912 Angstroem. At smaller wavelengths,
astronomical sources are strongly absorbed by the interstellar medium. It also
marks a technical limit, because telescopes and instruments are of different
design. In the EUV range, the technology is strongly related to that utilized
in X-ray astronomy, while in the UV range the instruments in many cases have
their roots in optical astronomy. We will, therefore, describe the UV and EUV
instruments in appropriate conciseness and refer to the respective chapters of
this volume for more technical details.Comment: To appear in: Landolt-Boernstein, New Series VI/4A, Astronomy,
Astrophysics, and Cosmology; Instruments and Methods, ed. J.E. Truemper,
Springer-Verlag, Berlin, 201
Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial
Background
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.
Methods
FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762.
Findings
Between Sept 10, 2012, and March 31, 2017, 3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99·3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0·951 [95% CI 0·839–1·079]; p=0·439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13·43%] patients vs 269 [17·21%]; difference 3·78% [95% CI 1·26–6·30]; p=0·0033), but they had more bone fractures (45 [2·88%] vs 23 [1·47%]; difference 1·41% [95% CI 0·38–2·43]; p=0·0070). There were no significant differences in any other event at 6 or 12 months.
Interpretation
Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function.
Funding
UK Stroke Association and NIHR Health Technology Assessment Programme
Special phase mask and related data format for page-based holographic data storage systems
Random phase masks in object and reference beam of page-based holographic storage systems suppress the DC-peak and improve the overlap of both beams inside the storage material. Furthermore, they allow for a narrow shift-selectivity. In a holographic setup the phase mask has to be introduced at a conjugate image plane of the spatial light modulator (SLM), if it is not fixed directly on the SLM itself. A binary phase mask with cells generating 0 and π phase shifts has to be aligned very accurately with respect to the SLM pixels, otherwise image artifacts disturb the received data page. We present a phase mask, where the phase cells have the size of a data block which consists of a rectangular set of SLM pixels. Additionally, the corresponding data page has no data at the position of phase jumps and thus relaxes the alignment tolerance significantly