Evaluating evapotranspiration Values in Rwanda while Using the Turc and Hargreaves-Samani Equations.

Evapotranspiration (ET) is an important component of the hydrologic cycle and involves the exchange of water between the surrounding water bodies, soil, crop surfaces, and the atmosphere. Crop growth and yields are largely affected by the rate of ET, especially in semi-arid areas where the rate of ET is high and rainfall is not sufficient and reliable to add more water into the soil for crop use. Solar radiation, relative humidity, air temperature, rainfall, and wind velocity are some of the meteorological factors that affect ET. Therefore, this research was aimed at determining ET and its trend across Rwanda using climatic data measured at 5 sites. With the research, we accessed meteorology data measured at synaptic stations in the five provinces of Rwanda (Kigali city/central, Kawangire/Eastern, Ruberengera/Western, Ruhengeri/Northern and Gikongoro/ and used the data to calculate reference evapotranspiration (ET) for the recent 10 years (2010-2018). Equations were used to calculate extra-terrestrial radiations, solar radiations, evapotranspiration using the FAO-56 guidelines - Turc method (1961) and Hargreaves-Samani (HS) method (1983). The obtained data was analyzed using the two methods and graph were plotted for visualization. Both methods have performed well in semi-humid and semi-arid environmental conditions. The average monthly reference evapotranspiration for both equations ranges from 3 to 5 mm/day. The Hu-Ts graphs for all the five locations shows a low value of reference ET (3 to 4 mm/day) for the year of 2018 compared to the previous years. Generally, there was consistency in variation in the reference ET throughout the 10 years for both the equations. The Turc method underestimates reference ET value compared to the HS method. The difference and variation of reference crop evapotranspiration for both the equations might have been due to the different locations since they have variations in climatic conditions that contributes a lot to the evapotranspiration value in the region

Water-energy-food linkages in community smallholder irrigation schemes: Center pivot irrigation in Rwanda

Water, energy, and food are linked in intricate ways in irrigated agriculture and understanding the interplay of these components is crucial for sustainable and profitable crop production, particularly in smallholder setting such as in sub-Saharan Africa. This study evaluates water-energy-food linkages, engineering and economic performance, irrigation decision making, and challenges faced around water management in a community-based mechanized irrigation scheme in Rwanda. The research is the first to analyze such as scheme, which uses technology typically used by large farmers in a smallholder setting. The study investigates the variation in water requirements and the relationship and impacts of this variability on crop yield for the crops grown in the scheme: maize, French beans, and dry beans. Observed irrigation decision-making analyses demonstrate a lack of irrigation planning during growth stages and significant field-to-field variation in irrigation; this is linked to yield reduction in major crops. Results suggest that farmers irrigated only 31% of modeled irrigation water in dry beans and 27% of modeled irrigation water in maize. An econometric model assessment is used to understand the relationship between yield and energy inputs. A related policy analysis considers the impacts of changes in crop and water management on field-level profits and system-level financial sustainability. This study has implications for understanding irrigation policies in the context of the water-energy-food nexus and decision-making in Sub- Saharan Africa

Crop response to thermal stress without yield loss in irrigated maize and soybean in Nebraska

Thermal sensing provides rapid and accurate estimation of crop water stress through canopy temperature data. Canopy temperature is highly dependent on the transpiration rate of the leaves. It is usually assumed that any reduction in crop evapotranspiration (ET) leads to crop yield loss. As a result, an increase in canopy temperature due to a decrease in crop ET would indicate crop yield loss. This research evaluated the hypothesis that crop water stress could be detected using canopy temperature measurements (increased leaf temperature) from infrared thermometers (IRTs) before incurring crop yield loss. This would be possible in a narrow range when the photosynthesis rate (and carbon assimilation) is limited by solar radiation (energy-limiting water stress) while the leaf has abundant carbon dioxide for photosynthesis. Once photosynthesis becomes limited by carbon dioxide (carbon-dioxide-limiting water stress), then yield reduction would occur. In this field experiment, measured response variables included the integrated crop water stress index (iCWSI), ET, and crop yield for maize and soybean during the 2020 and 2021 growing seasons. The irrigation was applied at four different refill levels: rainfed (0%), deficit (50%), full (100%), and over (150%). The irrigation depth was prescribed using four different irrigation methods. The field was irrigated with a center pivot irrigation system, which was also used as a platform to mount IRT sensors. The iCWSI thresholds required for irrigation management were determined using the iCWSI dataset collected in 2020. The low, medium, and high iCWSI thresholds were 120, 150, and 180, respectively for maize and 110, 130, and 150, respectively for soybean. These thresholds should be updated with iCWSI data from future studies in this region to increase the credibility of the thresholds for irrigation management. The mean iCWSI values for consecutive days after a wetting event substantially increased with time for each irrigation level and a larger range in iCWSI values was observed among the irrigation levels after three days from a wetting event. The seasonal iCWSI for different levels were found to be negatively correlated with seasonal evapotranspiration for both years. The correlations between seasonal ET and crop yield were significant with the rainfed and deficit levels for maize (p-value \u3c 0.001) and soybean (p-value = 0.04) in 2020. The iCWSI and yield data for the fully watered plots indicated that thermal stress was detected using the sensing system without incurring yield loss (i.e., energy-limiting water stress). The ET and yield data for 2021 indicated that reduction in seasonal crop ET did not result in yield loss which also supported the hypothesis. Future studies should investigate whether this phenomenon of detecting crop water stress in an early stage without yield loss is observed in other climates and locations

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

INTRODUCTION: Apolipoprotein E (apoE) is a carrier for brain lipids and the most important genetic risk factor for Alzheimer's disease (AD). ApoE binds the receptor sortilin, which mediates uptake of apoE‐bound cargo into neurons. The significance of this uptake route for brain lipid homeostasis and AD risk seen with apoE4, but not apoE3, remains unresolved. METHODS: Combining neurolipidomics in patient specimens with functional studies in mouse models, we interrogated apoE isoform–specific functions for sortilin in brain lipid metabolism and AD. RESULTS: Sortilin directs the uptake and conversion of polyunsaturated fatty acids into endocannabinoids, lipid‐based neurotransmitters that act through nuclear receptors to sustain neuroprotective gene expression in the brain. This sortilin function requires apoE3, but is disrupted by binding of apoE4, compromising neuronal endocannabinoid metabolism and action. DISCUSSION: We uncovered the significance of neuronal apoE receptor sortilin in facilitating neuroprotective actions of brain lipids, and its relevance for AD risk seen with apoE4

Comparative analysis between condom use clusters and risk behaviours among portuguese university students

The research on condom use has been focused on high-risk individuals, paying less attention to those who have moderate risk or safe sexual conducts. In order to design accurate interventions, potential differences among the condom use behavior groups must be considered. The goal was to assess possible differences in individuals presenting different types of risk behavior. 140 heterosexual university students answered a self-reported questionnaire about their sexual history, condom use habits, sexual self-esteem, sexual satisfaction, sexual control, attitudes towards condoms, self-efficacy to condom use, and emotions and feelings during sexual intercourse. A cluster analysis was conducted using the results about condom use and risk behaviors. Three groups with different risk levels emerged, presenting differences over sexual self-efficacy, attitudes towards condoms, socio-demographic variables, and sexual history. The results suggest the condom use inconsistency is highly associated with other risk behaviors but the contrary does not necessarily happens. Condom use consistent users also presented risk behaviors as smoking and drinking. The group differences suggest the risks were more affected by the combination of lack of skills with a negative attitude toward condoms than by contextual or personal variables. These differences sustain the need of an intervention adjusted to the individual's risk levels, since they differ on skills and beliefs that may hinder or promote the adoption of health behaviors.Foundation for Science and Technology/Fundacao para a Ciencia e Tecnologia (Portugal)info:eu-repo/semantics/publishedVersio

At the edge of intonation: the interplay of utterance-final F0 movements and voiceless fricative sounds

The paper is concerned with the 'edge of intonation' in a twofold sense. It focuses on utterance-final F0 movements and crosses the traditional segment-prosody divide by investigating the interplay of F0 and voiceless fricatives in speech production. An experiment was performed for German with four types of voiceless fricatives: /f/, /s/, /ʃ/ and /x/. They were elicited with scripted dialogues in the contexts of terminal falling statement and high rising question intonations. Acoustic analyses show that fricatives concluding the high rising question intonations had higher mean centres of gravity (CoGs), larger CoG ranges and higher noise energy levels than fricatives concluding the terminal falling statement intonations. The different spectral-energy patterns are suitable to induce percepts of a high 'aperiodic pitch' at the end of the questions and of a low 'aperiodic pitch' at the end of the statements. The results are discussed with regard to the possible existence of 'segmental intonation' and its implication for F0 truncation and the segment-prosody dichotomy, in which segments are the alleged troublemakers for the production and perception of intonation

Mindfulness-Based Cognitive Therapy (MBCT) For Health Anxiety (Hypochondriasis): Rationale, Implementation and Case Illustration.

Recent research has shown that mindfulness-based cognitive therapy (MBCT) could be a useful alternative approach to the treatment of health anxiety and deserves further investigation. In this paper, we outline the rationale for using MBCT in the treatment of this condition, namely its hypothesised impact on the underlying mechanisms which maintain health anxiety, such as rumination and avoidance, hypervigilance to body sensations and misinterpretation of such sensations. We also describe some of the adaptations which were made to the MBCT protocol for recurrent depression in this trial and discuss the rationale for these adaptations. We use a case example from the trial to illustrate how MBCT was implemented and outline the experience of one of the participants who took part in an 8-week MBCT course. Finally, we detail some of the more general experiences of participants and discuss the advantages and possible limitations of this approach for this population, as well as considering what might be useful avenues to explore in future research

Effectiveness of Provider and Community Interventions to Improve Treatment of Uncomplicated Malaria in Nigeria: A Cluster Randomized Controlled Trial

The World Health Organization recommends that malaria be confirmed by parasitological diagnosis before treatment using Artemisinin-based Combination Therapy (ACT). Despite this, many health workers in malaria endemic countries continue to diagnose malaria based on symptoms alone. This study evaluates interventions to help bridge this gap between guidelines and provider practice. A stratified cluster-randomized trial in 42 communities in Enugu state compared 3 scenarios: Rapid Diagnostic Tests (RDTs) with basic instruction (control); RDTs with provider training (provider arm); and RDTs with provider training plus a school-based community intervention (provider-school arm). The primary outcome was the proportion of patients treated according to guidelines, a composite indicator requiring patients to be tested for malaria and given treatment consistent with the test result. The primary outcome was evaluated among 4946 (93%) of the 5311 patients invited to participate. A total of 40 communities (12 in control, 14 per intervention arm) were included in the analysis. There was no evidence of differences between the three arms in terms of our composite indicator (p = 0.36): stratified risk difference was 14% (95% CI -8.3%, 35.8%; p = 0.26) in the provider arm and 1% (95% CI -21.1%, 22.9%; p = 0.19) in the provider-school arm, compared with control. The level of testing was low across all arms (34% in control; 48% provider arm; 37% provider-school arm; p = 0.47). Presumptive treatment of uncomplicated malaria remains an ingrained behaviour that is difficult to change. With or without extensive supporting interventions, levels of testing in this study remained critically low. Governments and researchers must continue to explore alternative ways of encouraging providers to deliver appropriate treatment and avoid the misuse of valuable medicines

Crisis discharges and readmission risk in acute psychiatric male inpatients

<p>Abstract</p> <p>Background</p> <p>Severe pressures on beds in psychiatric services have led to the implementation of an early ("crisis") discharge policy in the Western Cape, South Africa. The study examined the effect of this policy and length of hospital stay (LOS) on readmission rates in one psychiatric hospital in South Africa.</p> <p>Methods</p> <p>Discharge summaries of adult male patients (<it>n </it>= 438) admitted to Stikland Psychiatric Hospital during 2004 were retrospectively examined. Each patient's clinical course was then analysed for the period between January 1^st, 2004, and August 31^st, 2006.</p> <p>Results</p> <p>Although shorter LOS was associated with decreased readmission rates, the effect of crisis discharges was far more powerful. Patients discharged as usual had a far lower risk of readmission than those discharged due to bed pressures (i.e. crisis discharge).</p> <p>Conclusion</p> <p>Increased risks associated with the early discharge policy necessitate the urgent review of the current management of bed shortages in this inpatient facility. The strengthening of community initiatives, particularly assertive outreach could be a way forward.</p

LRP1 Receptor Controls Adipogenesis and Is Up-Regulated In Human and Mouse Obese Adipose Tissue

The cell surface low-density lipoprotein receptor-related protein 1, LRP1, plays a major role in lipid metabolism. The question that remains open concerns the function of LRP1 in adipogenesis. Here, we show that LRP1 is highly expressed in murine preadipocytes as well as in primary culture of human adipocytes. Moreover, LRP1 remains abundantly synthesised during mouse and human adipocyte differentiation. We demonstrate that LRP1 silencing in 3T3F442A murine preadipocytes significantly inhibits the expression of PPARγ, HSL and aP2 adipocyte differentiation markers after adipogenesis induction, and leads to lipid-depleted cells. We further show that the absence of lipids in LRP1-silenced preadipocytes is not caused by lipolysis induction. In addition, we provide the first evidences that LRP1 is significantly up-regulated in obese C57BI6/J mouse adipocytes and obese human adipose tissues. Interestingly, silencing of LRP1 in fully-differentiated adipocytes also reduces cellular lipid level and is associated with an increase of basal lipolysis. However, the ability of mature adipocytes to induce lipolysis is independent of LRP1 expression. Altogether, our findings highlight the dual role of LRP1 in the control of adipogenesis and lipid homeostasis, and suggest that LRP1 may be an important therapeutic target in obesity