78 research outputs found
Micromagnetic simulation of thermally assisted magnetization reversal in magnetic nanodots with perpendicular anisotropy
Temporal evolution of magnetization in a field cooling process from magnetic ordering temperature has been numerically investigated
for magnetic nanodots with perpendicular anisotropy by solving the stochastic Landau–Lifshitz–Gilbert equation. The magnetic field
required to align the magnetization, i.e. the switching field for thermally assisted writing of magnetic dot, depends on not only the
intrinsic anisotropy field but also the magnetization reversal mechanism. To minimize the switching field with ensuring a practical
thermal stability of the dot for nonvolatile memory applications, the lateral dimension of the dot should be smaller than its critical size
for single domain configuration to avoid a formation of flux closure configuration inside the dot.
Keywords: Numerical simulation; Nanodot magnetic; Perpendicular anisotropy; Thermally assisted; Magnetization reversa
Material Dependence of Thermally Assisted Magnetization Reversal Properties in Microstructured Co/Pd Multilayers
Using extraordinary Hall resistance (RH) measurements, the material dependence of thermally assisted magnetization reversal (TAMR)
was investigated for microstructured multilayers of [Co (0.17 nm)/Pd (0.80 nm)]N with N ¼ 7 and 20, which exhibit markedly different
magnetic properties. The threshold values of the external field (Hw,th) necessary for controlling the magnetization direction in TAMR,
obtained by direct application of a current pulse to the sample, were 220Oe for the N ¼ 7 and 710Oe for N ¼ 20 samples. The values of
Hw,th are found to be related to the magnetization saturation field at a critical temperature at which apparent coercivity decays
Stochastic simulation of thermally assisted magnetization reversal in sub-100 nm dots with perpendicular anisotropy
Thermally assisted magnetization reversal of sub-100 nm dots with perpendicular anisotropy has been
investigated using a micromagnetic Langevin model. The performance of the two different reversal
modes of (i) a reduced barrier writing scheme and (ii) a Curie point writing scheme are compared. For
the reduced barrier writing scheme, the switching field Hswt decreases with an increase in writing
temperature but is still larger than that of the Curie point writing scheme. For the Curie point writing
scheme, the required threshold field Hth, evaluated from 50 simulation results, saturates at a value,
which is not simply related to the energy barrier height. The value of Hth increases with a decrease in
cooling time owing to the dynamic aspects of the magnetic ordering process. Dependence of Hth on
material parameters and dot sizes has been systematically studied
Electric spectroscopy of vortex states and dynamics in magnetic disks
Spin-polarized radio frequency (RF) currents and RF-Oersted fields resonantly
excite a magnetic vortex core confined in a micron-scale soft magnetic disk. In
this study, we measured the rectifying voltage spectra caused by the
anisotropic magnetoresistance oscillation due to the gyration of the vortex
with different polarity and chirality. The measured spectra are presented such
that we can determine the vortex properties and strength of the spin torques
and Oersted field accurately and directly through analytical calculation.Comment: 39 pages,1 table, 10 figure
A Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E–Deficient Mice
ObjectivesThe aim of this study was to investigate the antiatherogenic effects of the dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin (DFS).BackgroundThe new class of anti–type 2 diabetes drugs, dipeptidyl peptidase-4 inhibitors, improves glucose metabolism by increasing levels of active glucagon-like peptide (GLP)-1.MethodsEndothelial function was examined by acetylcholine-induced endothelium-dependent vasorelaxation using aortic rings and atherosclerotic lesion development in the entire aorta in apolipoprotein E–deficient mice fed a high-fat diet with or without DFS, and the antiatherogenic effects of DFS were investigated in cultured human macrophages and endothelial cells. Plasma levels of active GLP-1 were measured in patients with or without coronary artery disease.ResultsDFS significantly improved endothelial dysfunction (89.9 ± 3.9% vs. 79.2 ± 4.3% relaxation at 10−4 mol/l acetylcholine, p < 0.05) associated with increased endothelial nitric oxide synthase phosphorylation and reduced atherosclerotic lesion area (17.7% [15.6% to 25.8%] vs. 24.6% [19.3% to 34.6%], p < 0.01) compared with vehicle treatment. In cultured human macrophages, DFS significantly increased GLP-1-induced cytosolic levels of cyclic adenosine monophosphate compared with GLP-1 alone, resulted in inhibiting phosphorylation of c-jun N-terminal kinase and extracellular signal-regulated kinase 1/2 and nuclear factor-kappa B p65 nuclear translocation through the cyclic adenosine monophosphate/protein kinase A pathway, and suppressed proinflammatory cytokines (i.e., interleukin-1-beta, interleukin-6, and tumor necrosis factor-alpha) and monocyte chemoattractant protein-1 production in response to lipopolysaccharide. DFS-enhanced GLP-1 activity sustained endothelial nitric oxide synthase phosphorylation and decreased endothelial senescence and apoptosis compared with GLP-1 alone. In the human study, fasting levels of active GLP-1 were significantly lower in patients with coronary artery disease than those without (3.10 pmol/l [2.40 to 3.62 pmol/l] vs. 4.00 pmol/l [3.10 to 5.90 pmol/l], p < 0.001).ConclusionsA DPP-4 inhibitor, DFS, exhibited antiatherogenic effects through augmenting GLP-1 activity in macrophages and endothelium
The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome.
X chromosomes are unusual in many regards, not least of which is their nonrandom gene content. The causes of this bias are commonly discussed in the context of sexual antagonism and the avoidance of activity in the male germline. Here, we examine the notion that, at least in some taxa, functionally biased gene content may more profoundly be shaped by limits imposed on gene expression owing to haploid expression of the X chromosome. Notably, if the X, as in primates, is transcribed at rates comparable to the ancestral rate (per promoter) prior to the X chromosome formation, then the X is not a tolerable environment for genes with very high maximal net levels of expression, owing to transcriptional traffic jams. We test this hypothesis using The Encyclopedia of DNA Elements (ENCODE) and data from the Functional Annotation of the Mammalian Genome (FANTOM5) project. As predicted, the maximal expression of human X-linked genes is much lower than that of genes on autosomes: on average, maximal expression is three times lower on the X chromosome than on autosomes. Similarly, autosome-to-X retroposition events are associated with lower maximal expression of retrogenes on the X than seen for X-to-autosome retrogenes on autosomes. Also as expected, X-linked genes have a lesser degree of increase in gene expression than autosomal ones (compared to the human/Chimpanzee common ancestor) if highly expressed, but not if lowly expressed. The traffic jam model also explains the known lower breadth of expression for genes on the X (and the Z of birds), as genes with broad expression are, on average, those with high maximal expression. As then further predicted, highly expressed tissue-specific genes are also rare on the X and broadly expressed genes on the X tend to be lowly expressed, both indicating that the trend is shaped by the maximal expression level not the breadth of expression per se. Importantly, a limit to the maximal expression level explains biased tissue of expression profiles of X-linked genes. Tissues whose tissue-specific genes are very highly expressed (e.g., secretory tissues, tissues abundant in structural proteins) are also tissues in which gene expression is relatively rare on the X chromosome. These trends cannot be fully accounted for in terms of alternative models of biased expression. In conclusion, the notion that it is hard for genes on the Therian X to be highly expressed, owing to transcriptional traffic jams, provides a simple yet robustly supported rationale of many peculiar features of X's gene content, gene expression, and evolution
Structural Control of Magnetic Properties in Co/Pd Multilayer for Heat Assisted Perpendicular MRAM Application
Micromagnetic Simulation of Microwave-Assisted Magnetization Switching Process for Granular Films
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