621 research outputs found
Assessing Mission Performance for Technology Reliant Missions
Operators today increasingly rely on technology to accomplish objectives. Although technology can increase mission success and efficiency in a majority of operations, it can simultaneously increase vulnerability prevalence, resulting in a higher exploitation likelihood. Defense methods have been proposed and evaluated based on their ability to ensure network security. However, these evaluation metrics do not fully quantify how network exploitation impacts mission task completion. Our mission performance model links cyber devices to mission tasks utilizing a mission’s mission map and evaluates a mission’s performance as the proportion of completed mission tasks in an agent based simulation. Our model allows for mission mappings with varying degrees of completion to enable a generic and adaptable model. We investigate the impact differing levels of mission map completion have on the mission performance metric for the same mission. Experiments serve to provide quantitative assessment for mission performance in cyber-network mission systems
First Results from a Broadband Search for Dark Photon Dark Matter in the to eV range with a coaxial dish antenna
We present first results from a dark photon dark matter search in the mass
range from 44 to 52 () using a
room-temperature dish antenna setup called GigaBREAD. Dark photon dark matter
converts to ordinary photons on a cylindrical metallic emission surface with
area and is focused by a novel parabolic reflector onto a horn
antenna. Signals are read out with a low-noise receiver system. A first data
taking run with 24 days of data does not show evidence for dark photon dark
matter in this mass range, excluding dark photon - photon mixing parameters
in this range at 90% confidence level. This surpasses
existing constraints by about two orders of magnitude and is the most stringent
bound on dark photons in this range below 49 eV.Comment: 7 pages, 4 figure
DU Undergraduate Showcase: Research, Scholarship, and Creative Works
DU Undergraduate Showcase: Research, Scholarship, and Creative Work
Design, construction, and functional characterization of a tRNA neochromosome in yeast
Here, we report the design, construction, and characterization of a tRNA neochromosome, a designer chromosome that functions as an additional, de novo counterpart to the native complement of Saccharomyces cerevisiae. Intending to address one of the central design principles of the Sc2.0 project, the ∼190-kb tRNA neochromosome houses all 275 relocated nuclear tRNA genes. To maximize stability, the design incorporates orthogonal genetic elements from non-S. cerevisiae yeast species. Furthermore, the presence of 283 rox recombination sites enables an orthogonal tRNA SCRaMbLE system. Following construction in yeast, we obtained evidence of a potent selective force, manifesting as a spontaneous doubling in cell ploidy. Furthermore, tRNA sequencing, transcriptomics, proteomics, nucleosome mapping, replication profiling, FISH, and Hi-C were undertaken to investigate questions of tRNA neochromosome behavior and function. Its construction demonstrates the remarkable tractability of the yeast model and opens up opportunities to directly test hypotheses surrounding these essential non-coding RNAs
Design, construction, and functional characterization of a tRNA neochromosome in yeast
Here, we report the design, construction, and characterization of a tRNA neochromosome, a designer chromosome that functions as an additional, de novo counterpart to the native complement of Saccharomyces cerevisiae. Intending to address one of the central design principles of the Sc2.0 project, the ∼190-kb tRNA neochromosome houses all 275 relocated nuclear tRNA genes. To maximize stability, the design incorporates orthogonal genetic elements from non-S. cerevisiae yeast species. Furthermore, the presence of 283 rox recombination sites enables an orthogonal tRNA SCRaMbLE system. Following construction in yeast, we obtained evidence of a potent selective force, manifesting as a spontaneous doubling in cell ploidy. Furthermore, tRNA sequencing, transcriptomics, proteomics, nucleosome mapping, replication profiling, FISH, and Hi-C were undertaken to investigate questions of tRNA neochromosome behavior and function. Its construction demonstrates the remarkable tractability of the yeast model and opens up opportunities to directly test hypotheses surrounding these essential non-coding RNAs
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