The use of hypoallergenic mixtures in children with signs of atopy

Question feeding children with clinical manifestations of atopy at impossibility of breastfeeding from a scientific point of view remains controversial. Evaluate the clinical effectiveness of a hypoallergenic diet therapy (HD) products based on the full or partial hydrolysis of serum protein in cow's milk (CMP) in infants with symptoms of atopic dermatitis (AD)

The effect of the nucleinat on functional activity blood granulocytes in school-age children with asthma, depending on acetylation phenotype

Introduction. Bronchial asthma is one of the most common diseases in the world, the number of patient with an ever increasing, especially among children. Inadequate efficiency of controlling asthma therapy necessitated the application of new drugs in children which have improved the course of the disease. Objective. To assess the Nucleinat effect in the treatment of asthma on indicators of the functional activity of blood granulocytes school-age children depend of their atsetylyatornyh phenotypes. Materials and Methods. 36 school-age children with bronchial asthma in remission were complex examined. All pupils in the complex basic therapy received Nucleinat 0,25 g per day for 21 days. Due to the type of acetylation patients were divided into two clinical groups. The first clinical group included 16 patients who determined the slow type of acetylation (average percentage acetylated sulfadimezin of urine was less than 75,0%). 20 students formed the second clinical group of, which is marked the rapid nature of acetylation (average percentage acetylated sulfadimezin urine was more than 75,0%). All children conducted by determining phagocytic activity and phagocytic number of blood neutrophil, analis of oxygen-dependent metabolism of eosinophilic and neutrophilic blood granulocytes due to parameters of spontaneous and stimulated Nitroblue tetrazolium test. Results. This definition of relative risk above the absolute number of neutrophils in farmazan positive spontaneous NBT-test less than 0,42 S. U. in pupils with the slow type of acetylation after therapy was 1,9 (95% CI 1,6-2,4) and absolute risk – 0,3. The using of Nucleinat with basic anti-inflammatory therapy in children with rapid type of acetylation compared to slow type of acetylation, accompanied by the risk of inadequate asthma control, namely the ability to increase the activity of the immune system (OR = 3,3, 95% CI 1,7-6,4)

Building a better model of cancer

The 2006 Cold Spring Harbor Laboratory meeting on the Mechanisms and Models of Cancer was held August 16–20. The meeting featured several hundred presentations of many short talks (mostly selected from the abstracts) and posters, with the airing of a number of exciting new discoveries. We will focus this meeting review on models of cancer (primarily mouse models), highlighting recent advances in new mouse models that better recapitulate sporadic tumorigenesis, demonstrations of tumor addiction to tumor suppressor inactivation, new insight into senescence as a tumor barrier, improved understanding of the evolutionary paths of cancer development, and environmental/immunological influences on cancer

The use of hypoallergenic mixtures in children with signs of atopy

Introduction. Studies are indicative that about a quarter of infants in Ukraine have atopic manifestations. If the breastfeeding is impossible, hypoallergenic mixtures should be used. The arm of the research. To establish clinico-paraclinical efficacy of hypoallergenic mixtures TM “Humana Ha” in infants with clinical manifestations of atopic abnormality of constitution. Methods. 27 children aged from 2 to 12 months with the symptoms of atopic dermatitis and 25 infants who were fed on formula and had the usual signs of wheezing syndrome underwent complex examination. Results. In the Ist clinical group among patients with mild forms of eczema (11,1%) score on EASI scale decreased from 28,8 ± 2,1 to score 12,2 ± 1,8 score (P <0,05). The using mixture “Humana-HA” was led to a decrease in absolute risk register high concentration of IL-4 in serum by 20,9%, relative risk reduction – 23,5% (95% CI 15,5-33,1), and the minimum number of patients which should be treatment to get one positive result was 4,2 (95% CI 1,2-10,4). Conclusions. The using of partially hydrolyzed mixture “Humana-HA” in infants with signs of atopic dermatitis significantly improves the flow of mild and moderate forms. Application of partial protein hydrolyzate ”Humana-HA” in the diet of infants with atopic dermatitis reduces the content of immunoglobulin E and interleukin-4 in serum

The modern possibilities of increasing the efficiency of basic anti-inflammation therapy of school-age children’s bronchial asthma

The effect of Nucleinat included in the basic therapy of bronchial asthma (BA) has been analyzed by means of double-blind, placebo-controlled method in 98 school age children. Two clinical groups were formed with the help of the table accidental numbers. The application of the Nucleinat in complex anti-inflammatory therapy of the BA was accompanied by decrease of bronchial hyperresponsiveness due to the possible reduction of the inflammatory process activity in the airways. The use of Nucleinat in the basic therapy of the school-age children significantly reduced the risk of moderate bronchial responsiveness: DAR – 28,5%, DRR – 54,8%, MNT – 1,8 (95% CІ 0,1-7,1)