Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: The Cardiovascular Health Study

Common polymorphisms in the CRP gene are associated with plasma CRP levels in population-based studies, but associations with age-related events are uncertain. A previous study of CRP haplotypes in older adults was broadened to include longevity and cause-specific mortality (all-cause, non-cardiovascular (nonCV), and cardiovascular (CV)). Common haplotypes were inferred from four tagSNPs in 4512 whites and five tagSNPs in 812 blacks from the Cardiovascular Health Study, a longitudinal cohort of adults over age 65. Exploratory analyses addressed early versus late mortality. CRP haplotypes were not associated with all-cause mortality or longevity overall in either population, but associations with all-cause mortality differed during early and late periods. In blacks, the haplotype tagged by 3872A (rs1205) was associated with increased risk of nonCV mortality, relative to other haplotypes (adjusted hazard ratio for each additional copy: 1.42, 95% CI: 1.07, 1.87). Relative to other haplotypes, this haplotype was associated with decreased risk of early but not decreased risk of late CV mortality in blacks; among whites, a haplotype tagged by 2667C (rs1800947) gave similar but nonsignificant findings. If confirmed, CRP genetic variants may be weakly associated with CV and nonCV mortality in older adults, particularly in self-identified blacks

Immobilienwirtschaft aktuell 2022: Beiträge zur immobilienwirtschaftlichen Forschung

Dieser Band enthält zehn aktuelle Beiträge zur Schweizer Immobilienwirtschaft. Die Arbeiten bieten raschen und einfachen Zugriff auf aktuelle Erkenntnisse aus den Themengebieten "Immobilieninvestment", "Immobilienmanagement", "Projektentwicklung" sowie "Urban Management". Die Publikation Immobilienwirtschaft aktuell erscheint jährlich und wird vom Center for Urban & Real Estate Management (CUREM) herausgegeben. Sie enthält die Zusammenfassungen der besten Abschlussarbeiten des Masters of Advanced Studies in Real Estate. Ziel ist die Förderung der akademischen und zugleich praxisnahen Diskussion immobilienrelevanter Themen in der Schweiz. Die vollständigen Abschlussarbeiten stehen auf www.curem.uzh.ch zum kostenlosen Download zur Verfügung. CUREM ist Teil der Wirtschaftswissenschaftlichen Fakultät an der Universität Zürich und widmet sich der immobilienwirtschaftlichen Forschung und Weiterbildung. Ziel ist die Förderung einer professionellen Immobilienwirtschaft in der Schweiz. Nebst dem RICS akkreditierten, berufsbegleitenden Studiengang zum "Master of Advanced Studies in Real Estate" und dem "Certificate of Advanced Studies in Urban Management" führt CUREM verschiedene Kompaktkurse, Expertenworkshops und Fachveranstaltungen durch

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n similar to 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n similar to 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders