Francia Márquez. Entre la oscuridad y las luces: resistencias, olvidos y política

This article is relevant due to the semantic load that Francia Márquez represents as a black woman within Colombian diplomacy, her speech linked to her wardrobe are seen as new ways of doing politics from meanings, representations and performance that open the way to the black community within of the hegemony of power. Likewise, it should be noted that black communities, especially women, have participated in organizational processes within their communities with a role as caretakers of the territory, of the victims, of peace and ancestral knowledge, keeping politics alive within their communities. However, reaching the point that Francia Márquez has within Colombian politics has been a historic moment that has caused discomfort to the elites, due to the role that a black woman, leader and activist represents in one of the most important positions in Colombia. . The question arises, what is the representation of the figure of Francia Márquez in the Colombian political scene? And for this we have proposed to analyze the representation of Francia Márquez as a black woman in Colombian politics, in order to identify the representations presented in the speech and clothing of the current vice president of Colombia. From a qualitative methodological proposal of content analysis.Este artículo es relevante debido a la carga semántica que Francia Márquez representa como mujer negra dentro de la diplomacia colombiana, su discurso ligado a su vestuario se ven como nuevas formas de hacer política desde significados, representaciones y performance que abren paso a la comunidad negra dentro de la hegemonía del poder. Igualmente, cabe resaltar que las comunidades negras en especial las mujeres, han participado en procesos organizativos dentro de sus comunidades con un papel de cuidadoras del territorio, de las víctimas, de la paz y el conocimiento ancestral, manteniendo la política viva dentro de sus comunidades, sin embargo, llegar al punto que Francia Márquez tiene dentro de la política colombiana ha sido un momento histórico que ha causado incomodidad a las elites, por el papel que una mujer negra, lideresa y activista representa en uno de los cargos más importantes de Colombia. Se plantea la pregunta, ¿Cuál es la representación de la figura de Francia Márquez en el panorama político colombiano? Y para ello nos hemos propuesto analizar la representación de Francia Márquez como mujer negra en la política colombiana, con el fin de identificar las representaciones presentadas en el discurso y la vestimenta de la actual vicepresidenta de Colombia. Desde una propuesta metodológica cualitativa de análisis de contenido

Francia Márquez. Entre la oscuridad y las luces: resistencias, olvidos y política

This article is relevant due to the semantic load that Francia Márquez represents as a black woman within Colombian diplomacy, her speech linked to her wardrobe are seen as new ways of doing politics from meanings, representations and performance that open the way to the black community within of the hegemony of power. Likewise, it should be noted that black communities, especially women, have participated in organizational processes within their communities with a role as caretakers of the territory, of the victims, of peace and ancestral knowledge, keeping politics alive within their communities. However, reaching the point that Francia Márquez has within Colombian politics has been a historic moment that has caused discomfort to the elites, due to the role that a black woman, leader and activist represents in one of the most important positions in Colombia. . The question arises, what is the representation of the figure of Francia Márquez in the Colombian political scene? And for this we have proposed to analyze the representation of Francia Márquez as a black woman in Colombian politics, in order to identify the representations presented in the speech and clothing of the current vice president of Colombia. From a qualitative methodological proposal of content analysis.Este artículo es relevante debido a la carga semántica que Francia Márquez representa como mujer negra dentro de la diplomacia colombiana, su discurso ligado a su vestuario se ven como nuevas formas de hacer política desde significados, representaciones y performance que abren paso a la comunidad negra dentro de la hegemonía del poder. Igualmente, cabe resaltar que las comunidades negras en especial las mujeres, han participado en procesos organizativos dentro de sus comunidades con un papel de cuidadoras del territorio, de las víctimas, de la paz y el conocimiento ancestral, manteniendo la política viva dentro de sus comunidades, sin embargo, llegar al punto que Francia Márquez tiene dentro de la política colombiana ha sido un momento histórico que ha causado incomodidad a las elites, por el papel que una mujer negra, lideresa y activista representa en uno de los cargos más importantes de Colombia. Se plantea la pregunta, ¿Cuál es la representación de la figura de Francia Márquez en el panorama político colombiano? Y para ello nos hemos propuesto analizar la representación de Francia Márquez como mujer negra en la política colombiana, con el fin de identificar las representaciones presentadas en el discurso y la vestimenta de la actual vicepresidenta de Colombia. Desde una propuesta metodológica cualitativa de análisis de contenido

Evidència de forçament climàtic natural i antròpic durant l'últim mil·lenni

Unidad de excelencia María de Maeztu MdM-2015-0552Un equip d'investigació multidisciplinar ha aconseguit un avanç important en el coneixement de les respostes terrestres i oceàniques a la variabilitat climàtica durant l'últim mil·lenni, incloent l'era industrial. Dos registres marins recuperats a la conca de la mar d'Alboran i analitzats a molt alta resolució han permès la reconstrucció de les condicions climàtiques i oceanogràfiques, així com la identificació d'influència antròpica a la regió més occidental de la Mediterrània durant aquest període de temps.A multidisciplinary international team has advanced in the understanding of the terrestrial and ocean responses to climate variability in the western Mediterranean during the past millennium including the industrial era. Two high-resolution deep-sea records from the Alboran Sea basin enabled the reconstruction of climate and oceanographic conditions as well as the identification of human fingerprints during this period

Neural stem cells in the adult olfactory bulb core generate mature neurons in vivo

Although previous studies suggest that neural stem cells (NSCs) exist in the adult olfactory bulb (OB), their location, identity, and capacity to generate mature neurons in vivo has been little explored. Here, we injected enhanced green fluorescent protein (EGFP)-expressing retroviral particles into the OB core of adult mice to label dividing cells and to track the differentiation/maturation of any neurons they might generate. EGFP-labeled cells initially expressed adult NSC markers on days 1 to 3 postinjection (dpi), including Nestin, GLAST, Sox2, Prominin-1, and GFAP. EGFP+ -doublecortin (DCX) cells with a migratory morphology were also detected and their abundance increased over a 7-day period. Furthermore, EGFP-labeled cells progressively became NeuN+ neurons, they acquired neuronal morphologies, and they became immunoreactive for OB neuron subtype markers, the most abundant representing calretinin expressing interneurons. OB-NSCs also generated glial cells, suggesting they could be multipotent in vivo. Significantly, the newly generated neurons established and received synaptic contacts, and they expressed presynaptic proteins and the transcription factor pCREB. By contrast, when the retroviral particles were injected into the subventricular zone (SVZ), nearly all (98%) EGFP+ -cells were postmitotic when they reached the OB core, implying that the vast majority of proliferating cells present in the OB are not derived from the SVZ. Furthermore, we detected slowly dividing label-retaining cells in this region that could correspond to the population of resident NSCs. This is the first time NSCs located in the adult OB core have been shown to generate neurons that incorporate into OB circuits in vivo

Characterization of the SNAG and SLUG Domains of Snail2 in the Repression of E-Cadherin and EMT Induction: Modulation by Serine 4 Phosphorylation

Snail1 and Snail2, two highly related members of the Snail superfamily, are direct transcriptional repressors of E-cadherin and EMT inducers. Previous comparative gene profiling analyses have revealed important differences in the gene expression pattern regulated by Snail1 and Snail2, indicating functional differences between both factors. The molecular mechanism of Snail1-mediated repression has been elucidated to some extent, but very little is presently known on the repression mediated by Snail2. In the present work, we report on the characterization of Snail2 repression of E-cadherin and its regulation by phosphorylation. Both the N-terminal SNAG and the central SLUG domains of Snail2 are required for efficient repression of the E-cadherin promoter. The co-repressor NCoR interacts with Snail2 through the SNAG domain, while CtBP1 is recruited through the SLUG domain. Interestingly, the SNAG domain is absolutely required for EMT induction while the SLUG domain plays a negative modulation of Snail2 mediated EMT. Additionally, we identify here novel in vivo phosphorylation sites at serine 4 and serine 88 of Snail2 and demonstrate the functional implication of serine 4 in the regulation of Snail2-mediated repressor activity of E-cadherin and in Snail2 induction of EMT

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Variabilidad climática en el oeste del Mediterráneo durante el Holoceno Tardío: una aproximación integrada de indicadores orgánicos e inorgánicos

Tesis Univ. Granada. Instituto Andaluz de Ciencias de la Tierra. Leída el 5 de marzo de 201