Environmentally Concerned Logistics Operations in Fuzzy Environment: A Literature Survey

Growing environmental awareness coupled with stricter governmental regulations has fueled the need for integrating sustainability into supply chain and logistics activities. Accordingly, recent studies in the literature have emphasized the significance of environmentally concerned logistics operations (ECLO). Research in the broad area of ECLO encompasses a wide range of topics including sustainable supply chain, green supply chain, closed-loop supply chain, low-carbon logistics, and waste management. In this paper, a comprehensive content analysis and area review is presented. Over 800 papers published between 1994 and 2017 in peer-reviewed journals, proceedings, and book chapters are utilized. These papers are analyzed in consecutive stages after being reviewed under a structural dimension process that addresses the fields of environmentally concerned logistics operations. Following the state-of-the-art review, a detailed analysis of ECLO research with a special emphasis on fuzzy applications is provided. The findings clearly indicate that the fuzzy multi-criteria decision making technique is a frequently used hybrid method, whereas fuzzy sets theory and other fuzzy hybrid techniques identify a gap in the related literature. This paper provides further critical analysis and other research suggestions in order to clarify these gaps and offer additional research perspectives. This information may provide extensive data that will enable future researchers to fill these gaps within this field.https://doi.org/10.3390/logistics101000

Characterization in vitro and in vivo of a pandemic H1N1 influenza virus from a fatal case

Pandemic 2009 H1N1 (pH1N1) influenza viruses caused mild symptoms in most infected patients. However, a greater rate of severe disease was observed in healthy young adults and children without co-morbid conditions. Here we tested whether influenza strains displaying differential virulence could be present among circulating pH1N1 viruses. The biological properties and the genotype of viruses isolated from a patient showing mild disease (M) or from a fatal case (F), both without known co-morbid conditions were compared in vitro and in vivo. The F virus presented faster growth kinetics and stronger induction of cytokines than M virus in human alveolar lung epithelial cells. In the murine model in vivo, the F virus showed a stronger morbidity and mortality than M virus. Remarkably, a higher proportion of mice presenting infectious virus in the hearts, was found in F virus-infected animals. Altogether, the data indicate that strains of pH1N1 virus with enhanced pathogenicity circulated during the 2009 pandemic. In addition, examination of chemokine receptor 5 (CCR5) genotype, recently reported as involved in severe influenza virus disease, revealed that the F virus-infected patient was homozygous for the deleted form of CCR5 receptor (CCR5Δ32).Funding Statement: This work was supported by Instituto de Salud Carlos III (Programa especial de investigación sobre la gripe pándemica GR09/0023, GR09/0040, GR09/0039) and Ciber de Enfermedades Respiratorias. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics

Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is poor, with five year osteosarcoma survival rates in people not having improved in decades. For dogs, one year survival rates are only around ~45%. Improved and novel treatment regimens are urgently required to improve survival in both humans and dogs with OSA. Utilising information from genetic studies could assist in this in both species, with the higher incidence rates in dogs contributing to the dog population being a good model of human disease. This review compares the clinical characteristics, gross morphology and histopathology, aetiology, epidemiology, and genetics of canine and human osteosarcoma. Finally, the current position of canine osteosarcoma genetic research is discussed and areas for additional work within the canine population are identified