Formation Evaluation of Lower Goru Sands of Khipro Block, Lower Indus Basin, Pakistan

Formation evaluation is widely used in exploration and production in order to minimize the risk, uncertainty, and understanding of the detailed characteristics of potential reservoir rocks. This study is aimed to evaluate the Petrophysical characteristics of upper and lower basal sands of the Cretaceous lower Goru Formation in Niamat-01 and Siraj-01 wells and to focus on hydrocarbon exploration potential. These wells have been drilled in the Khipro block, lower Indus basin, which is the least explored for the reservoir quality evaluation. Present study characterized the lower Goru sands of the Khipro block. It is interpreted that the thickness of upper and lower Basal sands are 13m and 10m, respectively in Naimat Basal 01, whereas 9m and 17m, respectively, are reported in SirajSouth-01. The average effective porosity is 11% in upper Basal sands while 26% is interpreted for lower Basal sand in Naimat Basal-01. An average porosity of 11% is found for upper Basal sands in Siraj South-01 and 11% for lower Basal sand. Water saturation (Sw) calculated for upper and lower Basal sands are 22% and 19%, respectively. The hydrocarbon saturation (Sh) of 78% is interpreted for upper Basal sands and 81% hydrocarbon saturation reported for lower Basal sands in Naimat basal-01. However, 36% and 45% Sw have been recognized for upper and lower Basal sands, respectively. Whereas hydrocarbon saturations of 64% and 55% are reported for the upper and lower basal sands, respectively, in SirajSouth-01. Crossover effects in front of targeted formations confirmed the presence of hydrocarbons in the zone of interest. Lower sands of the lower Goru Formation in the Khipro block are favorable for hydrocarbon production and have potential for future hydrocarbon exploration activities

Easy Movement Facilities for Users' Comfort in Shopping Malls in Clifton, Karachi, Pakistan

peer reviewedIn society, shopping plays a part in outdoor activity. With the passage of time, different societies develop different modes of shopping by following particular societal values and norms. Modern shopping is a modified activity that is widely adopted by shopping malls. In this new set of shopping activities, users of shopping malls are not interested only in shopping but also in allied facilities like a ramp, main entrance of the mall, wheelchair, information desk/ reception, informal seating, signage system/wayfinding, emergency exit, central circulation, horizontal circulation, wide walkways/corridors, staircase, elevator/lift, escalators and cargo lift. Some basic facilities are unavoidable while designing a shopping mall, but these facilities may differ in different shopping malls. One of the specialities of the specific mall is a user-based facility which is the main attribute of shopping malls. This study emphasises selected attributes of a shopping mall, i.e., easy movement facilities. Emerald Mall in the city of Karachi, Pakistan, was selected as a case study building. A quantitative and qualitative research methodology has been adopted; the collected data was then presented statistically. An analysis of the findings has been carried out according to the standard attributes of the shopping mall. The conclusion of the study includes that some of the areas of Emerald Mall are well established, but there is still a need for improvements in many areas, such as the ramp, main entrance of the mall, wheelchair, information desk/reception, informal seating, signage system/wayfinding, emergency exit, central circulation, horizontal circulation, wide walkways/corridors, staircase, elevator/lift, escalators, and cargo lift. The research establishes its contribution as the provision of framework and modular analysis of selected study for a contextual approach to architectural design development. This study recommends innovation for the future in the design of the selected mall in order to address the discrepancies identified.8. Decent work and economic growt

A randomized controlled behavioral intervention trial to improve medication adherence in adult stroke patients with prescription tailored Short Messaging Service (SMS)-SMS4Stroke study.

Background: The effectiveness of mobile technology to improve medication adherence via customized Short Messaging Service (SMS) reminders for stroke has not been tested in resource poor areas. We designed a randomized controlled trial to test the effectiveness of SMS on improving medication adherence in stroke survivors in Pakistan. Methods: This was a parallel group, assessor-blinded, randomized, controlled, superiority trial. Participants were centrally randomized in fixed block sizes. Adult participants on multiple medications with access to a cell phone and stroke at least 4 weeks from onset (Onset as defined by last seen normal) were eligible. The intervention group, in addition to usual care, received reminder SMS for 2 months that contained a) Personalized, prescription tailored daily medication reminder(s) b) Twice weekly health information SMS. The Health Belief Model and Social Cognitive theory were used to design the language and content of messages. Frontline SMS software was used for SMS delivery. Medication adherence was self-reported and measured on the validated Urdu version of Morisky Medication Adherence Questionnaire. Multiple linear regression was used to model the outcome against intervention and other covariates. Analysis was conducted by intention-to-treat principle. Results: Two hundred participants were enrolled. 38 participants were lost to follow-up. After 2 months, the mean medication score was 7.4 (95 % CI: 7.2–7.6) in the intervention group while 6.7 (95 % CI: 6.4–7.02) in the control group. The adjusted mean difference (Δ) was 0.54 (95 % CI: 0.22–0.85). The mean diastolic blood pressure in the intervention group was 2.6 mmHg (95 % CI; −5.5 to 0.15) lower compared to the usual care group. Conclusion: A short intervention of customized SMS can improve medication adherence and effect stroke risk factors like diastolic blood pressure in stroke survivors with complex medication regimens living in resource poor areas

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Homogeneous hydrogenation catalysed by square planar iridium (I) complexes

A study is described of the kinetics of reactions in which the complexes trans-Ir (CO)X(PPh₃)₂, where X = Cl, Br and I, are used for the catalytic homogeneous hydrogenation of olefins, in particular maleic acid. The catalytic activity is poor in benzene solutions but is enhanced in coordinating solvents such as N, N'-dimethylacetamide. The kinetics were studied by measurements of hydrogen uptake, at various experimental conditions in which iridium, olefin and hydrogen concentrations were varied. The rate-law is complex showing between zero and first order in each of iridium, substrate and hydrogen concentrations. The dependence of rate on the halogen followed the order I>Br>Cl, and quite remarkably traces of oxygen in the system enhance the hydrogenation rate considerably. Supplementary spectrophotometry studies have elucidated some of the equilibria involved and the mechanisms proposed show the importance of a solvent assisted dissociation step in making available a coordination site on the transition metal complex. A detailed path for the catalytic hydrogenation is suggested.Science, Faculty ofChemistry, Department ofGraduat

Synthesis and Antimicrobial Assessment of Fe3+ Inclusion Complex of p-tert-Butylcalix[4]arene Diamide Derivative

Present study deals with the synthesis of the p-tert-butylcalix[4]arene diamide derivative as ligand (L) and its Fe3+ complex, followed by its characterization using TLC and FT-IR, while UV-Vis and Job’s plot study were performed for complex formation. Antimicrobial activity of the derivative (L) and its metal complex was carried out by the disc diffusion method against bacteria (Escherichia coli and Staphylococcus albus) and fungi (R. stolonifer). Different concentrations of the derivative (L) (6, 3, 1.5, 0.75, and 0.37 μg/mL) and its Fe3+ complex were prepared, and Mueller–Hinton agar was used as the medium for the growth of microorganisms. Six successive dilutions of the derivative (L) and Fe3+ complex were used against microorganisms. Two successive dilutions (6 and 3 μg/mL) of the derivative (L) showed antibacterial action against both Gram-positive and Gram-negative bacteria. In addition, three successive dilutions (6, 3, and 1.5 μg/mL) of the derivative (L) showed antifungal activity. However, all of six dilutions of the Fe3+ complex showed antimicrobial activity. Derivative (L) showed 3 and 1.5 μg/mL minimum inhibitory concentrations (MIC) against bacteria and fungi, respectively. On the contrary, its Fe3+ complex showed 0.37 μg/mL value of MIC against bacteria and fungi. Hence, Fe3+ complex of the derivative (L) was found to be a more effective antimicrobial agent against selected bacteria and fungi than the diamide derivative (L)