Michiganders Can Unite to Fight the Pandemic. We've Done it Before.

http://deepblue.lib.umich.edu/bitstream/2027.42/166458/1/Michiganders Can Unite to Fight the Pandemic. We're Done it Before. Detroit Free Press November 12, 2020.pdfSEL

Urothelial bladder carcinoma with major clinical presentation as overactive bladder, without hematuria: case report and literature review

The urothelial carcinoma is the most common type of bladder cancer, comprising approximately 90% of cases in the United States. The most common symptom of bladder cancer is macroscopic hematuria, increased urinary frequency, urgency, or irritative symptoms may occur. Generally, occurs in elderly people, about 9 out of 10 people are over 55 years old, with the average age at diagnosis of 73 years. Males are more likely than women to have this neoplasm with a probability of 1 in 27 (for women the probability is 1 in 89). Most bladder cancers begin in the inner layer, also called the urothelium or transitional epithelium. As it advances, it invades the layers of the bladder and can invade adjacent structures, often metastasizing to distant lymph nodes, bones, lungs or the liver. Among the cancers that originate in the bladder authors have: Urothelial carcinoma (transitional cell carcinoma), squamous cell carcinoma, adenocarcinoma, small cell carcinoma, sarcoma. Hematuria occurs in the majority of patients with urothelial carcinoma. Symptoms such as dysuria, frequency, urgency and pain may also occur, or it may also be asymptomatic.  In this case report, an atypical presentation of bladder cancer is shown, simulating the symptomatology of a Hyperactive Bladder Syndrome

The structure of the nuclear stellar cluster of the Milky Way

We present high-resolution seeing limited and AO NIR imaging observations of the stellar cluster within about one parsec of Sgr A*, the massive black hole at the centre of the Milky Way. Stellar number counts and the diffuse background light density were extracted from these observations in order to examine the structure of the nuclear stellar cluster.Our findings are as follows: (a) A broken-power law provides an excellent fit to the overall structure of the GC nuclear cluster. The power-law slope of the cusp is $\Gamma=0.19\pm0.05$, the break radius is $R_{\rm break} = 6.0'' \pm 1.0''$ or $0.22\pm0.04$ pc, and the cluster density decreases with a power-law index of $\Gamma=0.75\pm0.1$ outside of $R_{\rm break}$. (b) Using the best velocity dispersion measurements from the literature, we derive higher mass estimates for the central parsec than assumed until now. The inferred density of the cluster at the break radius is $2.8\pm1.3\times 10^{6} {\rm M_{\odot} pc^{-3}}$. This high density agrees well with the small extent and flat slope of the cusp. Possibly, the mass of the stars makes up only about 50% of the total cluster mass. (c) Possible indications of mass segregation in the cusp are found (d) The cluster appears not entirely homogeneous. Several density clumps are detected that are concentrated at projected distances of $R=3''$ and $R=7''$ from Sgr A*.(e) There appears to exist an under-density of horizontal branch/red clump stars near $R=5''$, or an over-density of stars of similar brightness at $R=3''$ and $R=7''$. (f) The extinction map in combination with cometary-like features in an L'-band image may provide support for the assumption of an outflow from Sgr A*.Comment: accepted for publication by A&A; please contact first author for higher quality figure

The Student Movement Volume 107 Issue 13: We\u27ve Got the Spirit: Students Celebrate Dr. Luxton

HUMANS Best of Bon Appetit, Nora Martin Interview with the Dean of Lamson and Meier Halls, Interviewed by: Grace No The Joy of Japan, Interviewed by: Gloria Oh ARTS & ENTERTAINMENT A Creation Adventure, Nathaniel Reid Currently: Velma, Solana Campbell Suite Dreams for Sweet Dreams, Skylor Stark Where do I Find God? Part II, Anonymous NEWS AUSA Celebrates 100 Years of Student-Led Action, Andrew Francis Response to A House Divided Story, Christon Arthur, Provost Where\u27s the Harm in True Crime?. Abigail Kim IDEAS Redefining Free Agency in Sports, Andrew Francis Flying Cars of 2030, Rachel Ingram-Clay The Spooky Nature of Our Physical World, Alexander Navarro The State of AI, Abby Shim PULSE Debunking Myths Surrounding J.N. Andrews Honors Program, Gloria Oh Our Dear AU: A Spirit Week Tour, Lexie Dunham Romance and Reading, Gloria Oh LAST WORD An Ode to Tea, Alexander J. Hesshttps://digitalcommons.andrews.edu/sm-107/1012/thumbnail.jp

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource

Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. Secondary confirmatory and orthogonal intracellular anti-parasiticidal assays were conducted, and the potential for non-specific cytotoxicity determined. Hit compounds were chemically clustered and triaged for desirable physicochemical properties. The hypothetical biological target space covered by these diversity sets was investigated through bioinformatics methodologies. Consequently, three anti-kinetoplastid chemical boxes of ~200 compounds each were assembled. Functional analyses of these compounds suggest a wide array of potential modes of action against kinetoplastid kinases, proteases and cytochromes as well as potential host–pathogen targets. This is the first published parallel high throughput screening of a pharma compound collection against kinetoplastids. The compound sets are provided as an open resource for future lead discovery programs, and to address important research questions.The support and funding of Tres Cantos Open Lab Foundation is gratefully acknowledgedPeer reviewe

The Student Movement Volume 107 Issue 22: Fulfilled: AU Presents a Story of Redemption

HUMANS Speaking Up With Women, Interviewed by: Grace No What is it Like to Work at the Athletics Department?, Interviewed by: Grace No What is Title IX?. Interviewed by: Caryn Cruz ARTS & ENTERTAINMENT Currently: Foreign Film, Solana Campbell Fulfilled: A Musical of Redemption, Aiko J. Ayala Rios NEWS KASA Banquet, Interviewed by: Anna Pak Watchmen A Capella Concert: Unstoppable: A Journey Through Self-Discovery , Gloria Oh IDEAS Charge It!, Alexander Navarro Feminism is for Everybody. Yes-Even You, Dude!, Reagan McCain Tick Tock... for TikTok?, Abby Shim PULSE Dorm Delicacies, Melissa Moore How Have We Grown?, Abraham Bravo What Do We Wish We Did?, Abraham Bravo LAST WORD Take It From Me , SM Section Editorshttps://digitalcommons.andrews.edu/sm-107/1021/thumbnail.jp

The Student Movement Volume 107 Issue 1: We\u27re Back: Andrews Begins First Post-Covid School Year

HUMANS Interview of NEST performer: Sandrine Adap, Interviewed by: Nora Martin Meet Helena Hilton!, Interviewed by: Nora Martin Meet Aya Pagunsan, AUSA President, Interviewed by: Lauren Kim ARTS & ENTERTAINMENT Currently..., Solana Campbell Film and a Fling, Jonathon Woolford-Hunt Fleabag: Simply Human, Lily Rodriguez Summer Rewind, Ysabelle Fernando NEWS Andy\u27s Welcome Back Party, Gloria Oh News Analysis: Gun Violence in Cities, Julia Randall What\u27s New? Genesis Fellowship, Lauren Butler IDEAS Bring Balance to the Forest, Alexander Navaro In Rebuttal of Andrew Tate, Elizabeth Getahun Student Loan Forgiveness, Gabriela Francisco The Death of Her Majesty Queen Elizabeth II: The Right to Mourn (and Not), Alexander J. Hess PULSE Campus Life After Covid-19: A Newfound Freedom, Amelia Stefanescu Environmental Fridays Begins a New Season, Princella Tobias Freshmen Advice, Gloria Oh What to Eat in a Small Town, Lexie Dunhamhttps://digitalcommons.andrews.edu/sm-107/1000/thumbnail.jp

Evaluation of a novel microfluidic immuno-magnetic agglutination assay method for detection of dengue virus NS1 antigen

BACKGROUND: Dengue virus (DENV) is the most important arbovirus worldwide, causing infections in endemic countries and returning travellers from these areas. Rapid diagnostic tests are needed to improve patient management and monitor local transmission. The detection of DENV non-structural protein 1 (NS1) is a useful tool for the diagnosis, but the currently available methods can be time consuming or lack sensitivity. The objective of our study was to evaluate a new rapid and semi-quantitative microfluidic DENV NS1 immuno-magnetic agglutination assay based on aggregation of magnetic nanoparticles detected by an electronic reader (Virotrack Dengue Acute and Blubox, Blusense diagnostics, Copenhagen, Denmark). METHODOLOGY/PRINCIPAL FINDINGS: A panel of 135 serum samples from travelers returning from dengue endemic countries was analyzed (74 DENV positive samples including the four DENV serotypes, 26 Zika virus positive samples, 25 chikungunya virus positive samples, 5 malaria positive samples and 5 negative samples). Samples were tested by three different antigen detection methods: SD Dengue NS1 Ag ELISA, SD BIOLINE Dengue Duo and ViroTrack Dengue Acute. The sensitivity observed for SD Dengue NS1 Ag ELISA, ViroTrack Dengue Acute and SD BIOLINE Dengue Duo was 97.2%, 91.1% and 68.1%, respectively. All methods showed high specificity (98.4% for ViroTrack Dengue Acute and 100% for both SD Dengue NS1 Ag ELISA and SD BIOLINE Dengue Duo). SD Dengue NS1 Ag ELISA and ViroTrack Dengue Acute only failed to detect samples positive for DENV-2. CONCLUSIONS/SIGNIFICANCE: ViroTrack Dengue Acute is a sensitive and specific assay for DENV NS1 detection. It provides faster results than the ELISA method and a better performance than the rapid immunochromatographic tests. ViroTrack Dengue Acute could represent a valuable tool for rapid diagnosis of DENV infections in returning travellers from endemic countries

Multifunctional and compact 3D FMCW MIMO radar system with rectangular array for medium-range applications

Miralles-Navarro, E.; Multerer, T.; Ganis, A.; Schoenlinner, B.; Prechtel, U.; Meusling, A.; Mietzner, J.... (2018). Multifunctional and compact 3D FMCW MIMO radar system with rectangular array for medium-range applications. IEEE Aerospace and Electronic Systems Magazine. 33(4):46-54. https://doi.org/10.1109/MAES.2018.160277S465433