Exclusive 16O(γ,π-p) reaction in the Δ resonance region

We report the first exclusive (γ,π-p) measurements on a complex nucleus. The 16O(γ,π-p) reaction was measured at pion laboratory angles of 64° and 120°. Coincident protons were detected over the quasifree angular correlation range using a vertical array of seven plastic scintillator detectors spanning ±33° about the scattering plane. The cross sections are compared to factorized distorted-wave impulse approximation calculations; these provide a good description of the backward angle data, but are in serious disagreement with the forward angle data

Finite covers of random 3-manifolds

A 3-manifold is Haken if it contains a topologically essential surface. The Virtual Haken Conjecture posits that every irreducible 3-manifold with infinite fundamental group has a finite cover which is Haken. In this paper, we study random 3-manifolds and their finite covers in an attempt to shed light on this difficult question. In particular, we consider random Heegaard splittings by gluing two handlebodies by the result of a random walk in the mapping class group of a surface. For this model of random 3-manifold, we are able to compute the probabilities that the resulting manifolds have finite covers of particular kinds. Our results contrast with the analogous probabilities for groups coming from random balanced presentations, giving quantitative theorems to the effect that 3-manifold groups have many more finite quotients than random groups. The next natural question is whether these covers have positive betti number. For abelian covers of a fixed type over 3-manifolds of Heegaard genus 2, we show that the probability of positive betti number is 0. In fact, many of these questions boil down to questions about the mapping class group. We are lead to consider the action of mapping class group of a surface S on the set of quotients pi_1(S) -> Q. If Q is a simple group, we show that if the genus of S is large, then this action is very mixing. In particular, the action factors through the alternating group of each orbit. This is analogous to Goldman's theorem that the action of the mapping class group on the SU(2) character variety is ergodic.Comment: 60 pages; v2: minor changes. v3: minor changes; final versio

Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML

Little is known about whether risk classification at diagnosis predicts post-hematopoietic cell transplantation (HCT) outcomes in patients with acute myeloid leukemia (AML). We evaluated 8709 patients with AML from the CIBMTR database, and after selection and manual curation of the cytogenetics data, 3779 patients in first complete remission were included in the final analysis: 2384 with intermediate-risk, 969 with adverse-risk, and 426 with KMT2A-rearranged disease. An adjusted multivariable analysis detected an increased risk of relapse for patients with KMT2A-rearranged or adverse-risk AML as compared to those with intermediate-risk disease (hazards ratio [HR], 1.27; P 5.01; HR, 1.71; P,.001, respectively). Leukemia-free survival was similar for patients with KMT2A rearrangement or adverse risk (HR, 1.26; P 5.002, and HR, 1.47; P,.001), as was overall survival (HR, 1.32; P,.001, and HR, 1.45; P,.001). No differences in outcome were detected when patients were stratified by KMT2A fusion partner. This study is the largest conducted to date on post-HCT outcomes in AML, with manually curated cytogenetics used for risk stratification. Our work demonstrates that risk classification at diagnosis remains predictive of post-HCT outcomes in AML. It also highlights the critical need to develop novel treatment strategies for patients with KMT2A-rearranged and adverse-risk disease

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits : A Multi-Ethnic Meta-Analysis of 45,891 Individuals

J. Kaprio, S. Ripatti ja M.-L. Lokki työryhmien jäseniä.Peer reviewe

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Equable end Mesoproterozoic climate in the absence of high CO2

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/148578/1/Fiorella_and_Sheldon_2017_Geology-equable_climate_in_the_Mesoproterozoic.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/148578/2/Fiorella_and_Sheldon_2017_Geology-Supplemental_Text_2017060.pd

Selected Soil Properties Among Agroforestry, Natural Forest, Traditional Agriculture, and Palm Oil Land Uses in Central Kalimantan

The deforestation in Indonesia has begun in the twentieth century due to agricultural expansion and mechanization. The uncontrolled and illegal land conversions have affected forest functions, food security, and soil health. The objective of this study is to evaluate differences in soil properties among major land-use practices and determine agroforestry’s potential for soil rehabilitation. The study design consisted of palm oil plantation (POP), traditional agriculture (TA), agroforestry homegarden (AHG), and natural forest (NF) management treatments in completely randomized block design with three replications. Soil samples were collected from three villages Kuala Pembuang, Muara Dua, and Telaga Pulang within the Rimba Raya Biodiversity Reserve located in Seruyan District, Central Kalimantan Province, Indonesia, in June 2017. Soils from 0–15 cm and 15–30 cm were analyzed for cellulase, PMEase, urease, C, and N. The results showed that enzyme activities and percentages of C and N were significantly different (α 0.05) among management practices within the soil depths. The highest enzyme activities were found in NF, AHG, and TA treatments. The lowest C level was found at 0–15 cm soil depth (1.32%) of POP. The highest nitrogen level was found at NF (1.23%) for 15–30 cm soil depth followed by TA site at 0–15 cm (1.15%). The lowest soil N level was found at POP among treatments and depths (0.43% and 0.21%). The outcomes of this study will help formulate land management recommendations for landowners, palm oil management, government agencies, and communities around the study areas to maintain soil quality for long-term sustainability of the peat forest ecosystems. Homegarden systems can be recommended as the most appropriate alternative land management in Seruyan District, Central Kalimantan. Future research could investigate microbial community structure and characteristics to understand specific soil functions by treatments