СЛУЧАЙ ДИРОФИЛЯРИОЗА РАЗГИБАТЕЛЯ ПАЛЬЦЕВ КИСТИ, ИМИТИРУЮЩИЙ СУХОЖИЛЬНЫЙ ГАНГЛИЙ

Early diagnostics for parasitic diseases of musculoskeletal system is rather challenging due to rare occurrence of described pathology.The authors review a clinical case of a female patient, 49 years old, with dirofilariasis of tendinous sheath of extensor pollicis longus. The patient was admitted to hospital with a diagnosis of dorsal hand ganglion cyst. Correct diagnosis was made only after parasite extraction during surgical procedure. The authors discuss issues of differential diagnosis of such disease as well as dorsal hand ganglion. Diagnosis can be confirmed by preoperative ultrasound scans of hand soft tissues.Своевременная диагностика паразитарных заболеваний опорно-двигательного аппарата представляет определенные сложности,  обусловленные редкостью данной патологии. В статье представлено  клиническое наблюдение – случай дирофиляриоза влагалища  разгибателя пальца кисти у 49-летней  женщины, госпитализированной с диагнозом «гигрома тыльной поверхности кисти». правильный диагноз заболевания был поставлен только после извлечения паразита  во время операции.  Обсуждены проблемы  дифференциальной диагностики данного заболевания и гигромы  тыла  кисти.  Для  уточнения диагноза  предложено  использовать предоперационное узИ мягких тканей кисти

Time-of-flight and activation experiments on 147Pm and 171Tm for astrophysics

The neutron capture cross section of several key unstable isotopes acting as branching points in the s-process are crucial for stellar nucleosynthesis studies, but they are very challenging to measure due to the difficult production of sufficient sample material, the high activity of the resulting samples, and the actual (n,γ) measurement, for which high neutron fluxes and effective background rejection capabilities are required. As part of a new program to measure some of these important branching points, radioactive targets of 147Pm and 171Tm have been produced by irradiation of stable isotopes at the ILL high flux reactor. Neutron capture on 146Nd and 170Er at the reactor was followed by beta decay and the resulting matrix was purified via radiochemical separation at PSI. The radioactive targets have been used for time-of-flight measurements at the CERN n-TOF facility using the 19 and 185 m beam lines during 2014 and 2015. The capture cascades were detected using a set of four C6D6 scintillators, allowing to observe the associated neutron capture resonances. The results presented in this work are the first ever determination of the resonance capture cross section of 147Pm and 171Tm. Activation experiments on the same 147Pm and 171Tm targets with a high-intensity 30 keV quasi-Maxwellian flux of neutrons will be performed using the SARAF accelerator and the Liquid-Lithium Target (LiLiT) in order to extract the corresponding Maxwellian Average Cross Section (MACS). The status of these experiments and preliminary results will be presented and discussed as well

New measurement of the 242Pu(n,γ) cross section at n-TOF-EAR1 for MOX fuels : Preliminary results in the RRR

The spent fuel of current nuclear reactors contains fissile plutonium isotopes that can be combined with 238U to make mixed oxide (MOX) fuel. In this way the Pu from spent fuel is used in a new reactor cycle, contributing to the long-term sustainability of nuclear energy. The use of MOX fuels in thermal and fast reactors requires accurate capture and fission cross sections. For the particular case of 242Pu, the previous neutron capture cross section measurements were made in the 70's, providing an uncertainty of about 35% in the keV region. In this context, the Nuclear Energy Agency recommends in its "High Priority Request List" and its report WPEC-26 that the capture cross section of 242Pu should be measured with an accuracy of at least 7-12% in the neutron energy range between 500 eV and 500 keV. This work presents a brief description of the measurement performed at n-TOF-EAR1, the data reduction process and the first ToF capture measurement on this isotope in the last 40 years, providing preliminary individual resonance parameters beyond the current energy limits in the evaluations, as well as a preliminary set of average resonance parameters

The measurement programme at the neutron time-of-flight facility n-TOF at CERN

Neutron-induced reaction cross sections are important for a wide variety of research fields ranging from the study of nuclear level densities, nucleosynthesis to applications of nuclear technology like design, and criticality and safety assessment of existing and future nuclear reactors, radiation dosimetry, medical applications, nuclear waste transmutation, accelerator-driven systems and fuel cycle investigations. Simulations and calculations of nuclear technology applications largely rely on evaluated nuclear data libraries. The evaluations in these libraries are based both on experimental data and theoretical models. CERN's neutron time-of-flight facility n-TOF has produced a considerable amount of experimental data since it has become fully operational with the start of its scientific measurement programme in 2001. While for a long period a single measurement station (EAR1) located at 185 m from the neutron production target was available, the construction of a second beam line at 20 m (EAR2) in 2014 has substantially increased the measurement capabilities of the facility. An outline of the experimental nuclear data activities at n-TOF will be presented

Measurement of the 72Ge(n,γ) cross section over a wide neutron energy range at the CERN n_TOF facility

The Ge72(n,γ) cross section was measured for neutron energies up to 300keV at the neutron time-of-flight facility n_TOF (CERN), Geneva, for the first time covering energies relevant to heavy-element synthesis in stars. The measurement was performed at the high-resolution beamline EAR-1, using an isotopically enriched GeO272 sample. The prompt capture γ rays were detected with four liquid scintillation detectors, optimized for low neutron sensitivity. We determined resonance capture kernels up to a neutron energy of 43keV, and averaged cross sections from 43 to 300keV. Maxwellian-averaged cross section values were calculated from kT=5 to 100keV, with uncertainties between 3.2% and 7.1%. The new results significantly reduce uncertainties of abundances produced in the slow neutron capture process in massive stars

The content of vascular endothelial grow factor in saliva and serum in patients with periodontitis

To study the concentration of vasculoendothelial growth factor (VEGF) in mixed saliva and serum of patients in normal conditions and with generalized periodontitis. The main group (n = 42) was represented by patients with generalized periodontitis. The comparison group (n = 36) consisted of patients without periodontal tissue diseases. The concentration of VEFR was determined by the method of enzyme-linked immunosorbent assay (ELISA) using a commercial test-system "VEGF - IFA - BEST" (A-8784) ("Vector - Best", Russia). The median values VEFR in saliva were 5.49 times higher than the values for serum in the main group (p = 0.000000) and 7.01 times in the comparison group (p = 0.000000). The concentration of VEFR in the saliva of the examined main group exceeded the similar values of the comparison group (p = 0,014857); the median and interquartile range for the main group was 1098.45 (925.5; 1291) pg/ml, and for the comparison group 1360.5 (998.9; 2062) pg/ml. There were no differences in the serum VEFR concentration (p = 0.775124). No significant correlation was found between the serum VEFR content and the mixed saliva. The Spearman's rank correlation coefficient for the main group was R = 0,0184358, and for the comparison group, respectively, R = 0.188932. The source of VEFR in saliva are the glands and cells of the oral mucosa, and not the process of exudation from blood serum. The high content of VEFR in the saliva of healthy people and a decrease in its level during periodontitis indicates the important role of this protein in the processes of maintaining the normal state of periodontal tissues and reparation of tissues of the oral mucosa

СОДЕРЖАНИЕ ВАСКУЛОЭНДОТЕЛИАЛЬНОГО ФАКТОРА РОСТА В СЛЮНЕ И СЫВОРОТКЕ КРОВИ БОЛЬНЫХ ПАРОДОНТИТОМ

To study the concentration of vasculoendothelial growth factor (VEGF) in mixed saliva and serum of patients in normal conditions and with generalized periodontitis. The main group (n = 42) was represented by patients with generalized periodontitis. The comparison group (n = 36) consisted of patients without periodontal tissue diseases. The concentration of VEFR was determined by the method of enzyme-linked immunosorbent assay (ELISA) using a commercial test-system “VEGF - IFA - BEST” (A-8784) (“Vector - Best”, Russia). The median values VEFR in saliva were 5.49 times higher than the values for serum in the main group (p = 0.000000) and 7.01 times in the comparison group (p = 0.000000). The concentration of VEFR in the saliva of the examined main group exceeded the similar values of the comparison group (p = 0,014857); the median and interquartile range for the main group was 1098.45 (925.5; 1291) pg/ml, and for the comparison group 1360.5 (998.9; 2062) pg/ml. There were no differences in the serum VEFR concentration (p = 0.775124). No significant correlation was found between the serum VEFR content and the mixed saliva. The Spearman's rank correlation coefficient for the main group was R = 0,0184358, and for the comparison group, respectively, R = 0.188932. The source of VEFR in saliva are the glands and cells of the oral mucosa, and not the process of exudation from blood serum. The high content of VEFR in the saliva of healthy people and a decrease in its level during periodontitis indicates the important role of this protein in the processes of maintaining the normal state of periodontal tissues and reparation of tissues of the oral mucosa.Изучена концентрация васкулоэндотелиального фактора роста (ВЭФР) в смешанной нестимулированной слюне и сыворотке крови у пациентов в норме и при генерализованном пародонтите. Основная группа (n=42) была представлена больными с генерализованным пародонтитом. Группу сравнения (n=36) составили пациенты без заболеваний тканей пародонта. Концентрацию ВЭФР определяли методом твердофазного иммуноферментного анализа (ИФА) с использованием коммерческой тест - системы «VEGF - ИФА - БЕСТ» (А 8784) («Вектор - Бест», Россия). Медианы значений ВЭФР в слюне в 5,49 раза превышали значения для сыворотки крови в основной группе (p = 0,000000) и в 7,01 раза в группе сравнения (p = 0,000000). Концентрация ВЭФР в слюне больных основной группы превосходила аналогичные значения группы сравнения (p = 0,014857); медиана и интерквартильный диапазон для основной группы составили 1098,45 (925,5; 1291) пг/мл, а для группы сравнения 1360,5 (998,9 ; 2062) пг/мл. Различия в концентрации ВЭФР для сыворотки отсутствовали (p = 0,775124). Не выявлено достоверной корреляционной связи между содержанием ВЭФР в сыворотке крови и смешанной слюне. Коэффициент ранговой корреляции Спирмена для основной группы составил R=0,0184358, а для группы сравнения, соответственно, R=0,188932. Вероятным источником ВЭФР в слюне служат железы и клетки слизистой оболочки рта, а не процессы экссудации из сыворотки крови. Высокое содержание ВЭФР в слюне здоровых людей и снижение его уровня при пародонтите указывает на важную роль данного белка в процессах поддержания нормального состояния тканей пародонта и регенерации тканей слизистой оболочки рта

Mathematical Model of Hemodynamics.

Abstract: One of basic mathematical model of hemodynamic processes on a net of vessels with respect to heart and tissue and corresponding method of solution and programming tools are discussed.Note: Research direction:Mathematical problems and theory of numerical method