Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice.

Impaired early nutrition influences the risk of developing metabolic disorders in later life. We observed that transient postnatal overfeeding (OF) in mice induces long-term hepatic alterations, characterized by microsteatosis, fibrosis associated with oxidative stress (OS), and stress-induced premature senescence (SIPS). In this study, we investigated whether such changes can be reversed by moderate calorie restriction (CR). C57BL/6 male mice pups were maintained during lactation in litters adjusted to nine pups in the normal feeding (NF) group and three pups in the transient postnatal OF group. At six months of age, adult mice from the NF and OF groups were randomly assigned to an ad libitum diet or CR (daily energy supply reduced by 20%) for one month. In each group, at the age of seven months, analysis of liver structure, liver markers of OS (superoxide anion, antioxidant defenses), and SIPS (lipofuscin, p53, p21, p16, pRb/Rb, Acp53, sirtuin-1) were performed. CR in the OF group reduced microsteatosis, decreased levels of superoxide anion, and increased protein expression of catalase and superoxide dismutase. Moreover, CR decreased lipofuscin staining, p21, p53, Acp53, and p16 but increased pRb/Rb and sirtuin-1 protein expression. CR did not affect the NF group. These results suggest that CR reduces hepatic disorders induced by OF

Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction.

Myocardial infarction (MI) induces a sterile inflammatory response that contributes to adverse cardiac remodeling. The initiating mechanisms of this response remain incompletely defined. We found that necrotic cardiomyocytes released a heat-labile proinflammatory signal activating MAPKs and NF-κB in cardiac fibroblasts, with secondary production of cytokines. This response was abolished in Myd88(-/-) fibroblasts but was unaffected in nlrp3-deficient fibroblasts. Despite MyD88 dependency, the response was TLR independent, as explored in TLR reporter cells, pointing to a contribution of the IL-1 pathway. Indeed, necrotic cardiomyocytes released IL-1α, but not IL-1β, and the immune activation of cardiac fibroblasts was abrogated by an IL-1R antagonist and an IL-1α-blocking Ab. Moreover, immune responses triggered by necrotic Il1a(-/-) cardiomyocytes were markedly reduced. In vivo, mice exposed to MI released IL-1α in the plasma, and postischemic inflammation was attenuated in Il1a(-/-) mice. Thus, our findings identify IL-1α as a crucial early danger signal triggering post-MI inflammation

Triggering of the 2014 M_w7.3 Papanoa earthquake by a slow slip event in Guerrero, Mexico

Since their discovery two decades ago, slow slip events have been shown to play an important role in accommodating strain in subduction zones. However, the physical mechanisms that generate slow slip and the relationships with earthquakes are unclear. Slow slip events have been recorded in the Guerrero segment of the Cocos–North America subduction zone. Here we use inversion of position time series recorded by a continuous GPS network to reconstruct the evolution of aseismic slip on the subduction interface of the Guerrero segment. We find that a slow slip event began in February 2014, two months before the magnitude (M_w) 7.3 Papanoa earthquake on 18 April. The slow slip event initiated in a region adjacent to the earthquake hypocentre and extended into the vicinity of the seismogenic zone. This spatio-temporal proximity strongly suggests that the Papanoa earthquake was triggered by the ongoing slow slip event. We demonstrate that the triggering mechanism could be either static stress increases in the hypocentral region, as revealed by Coulomb stress modelling, or enhanced weakening of the earthquake hypocentral area by the slow slip. We also show that the plate interface in the Guerrero area is highly coupled between slow slip events, and that most of the accumulated strain is released aseismically during the slow slip episodes

Planck 2015 results: XXV. Diffuse low-frequency Galactic foregrounds

We discuss the Galactic foreground emission between 20 and 100 GHz based on observations by Planck and WMAP. The total intensity in this part of the spectrum is dominated by free-free and spinning dust emission, whereas the polarized intensity is dominated by synchrotron emission. The Commander component-separation tool has been used to separate the various astrophysical processes in total intensity. Comparison with radio recombination line templates verifies the recovery of the free-free emission along the Galactic plane. Comparison of the high-latitude H\u3b1 emission with our free-free map shows residuals that correlate with dust optical depth, consistent with a fraction (\ue2\u2030 30%) of H\u3b1 having been scattered by high-latitude dust. We highlight a number of diffuse spinning dust morphological features at high latitude. There is substantial spatial variation in the spinning dust spectrum, with the emission peak (in I\u3bd) ranging from below 20 GHz to more than 50 GHz. There is a strong tendency for the spinning dust component near many prominent H ii regions to have a higher peak frequency, suggesting that this increase in peak frequency is associated with dust in the photo-dissociation regions around the nebulae. The emissivity of spinning dust in these diffuse regions is of the same order as previous detections in the literature. Over the entire sky, the Commander solution finds more anomalous microwave emission (AME) than the WMAP component maps, at the expense of synchrotron and free-free emission. This can be explained by the difficulty in separating multiple broadband components with a limited number of frequency maps. Future surveys, particularly at 5-20 GHz, will greatly improve the separation by constraining the synchrotron spectrum. We combine Planck and WMAP data to make the highest signal-to-noise ratio maps yet of the intensity of the all-sky polarized synchrotron emission at frequencies above a few GHz. Most of the high-latitude polarized emission is associated with distinct large-scale loops and spurs, and we re-discuss their structure. We argue that nearly all the emission at 40deg > l >-90deg is part of the Loop I structure, and show that the emission extends much further in to the southern Galactic hemisphere than previously recognised, giving Loop I an ovoid rather than circular outline. However, it does not continue as far as the "Fermi bubble/microwave haze", making it less probable that these are part of the same structure. We identify a number of new faint features in the polarized sky, including a dearth of polarized synchrotron emission directly correlated with a narrow, roughly 20deg long filament seen in H\u3b1 at high Galactic latitude. Finally, we look for evidence of polarized AME, however many AME regions are significantly contaminated by polarized synchrotron emission, and we find a 2\u3c3 upper limit of 1.6% in the Perseus region

Three-dimensional extinction maps: Inverting inter-calibrated extinction catalogues

3D maps of the extinction density in the Galaxy can be built through the inversion of catalogues of distance-extinction pairs for individual target stars. The spatial resolution of the maps that can be achieved increases with the spatial density of the targets, and subsequently with the combination of catalogues. However, this requires their careful inter-calibration. Our aim is to develop methods of inter-calibration of two different catalogues. We used as reference a spectrophotometric catalogue. A principal component analysis was performed in G,GB,GR,J,H,K multi-colour space for the second catalog. The subspace constituted by the two first components was split into cells in which we estimated deviations from the reference. The deviations were computed using all targets from the reference located at a short spatial distance of each secondary target. Corrections and filtering were deduced for each cell in the multi-colour space. We applied the technique to two different datasets: on the one hand, the spectrophotometric catalogue, and, on the other hand, a catalogue of extinctions based on photometry of Gaia eDR3 and 2MASS. After calibration, the dispersion of the extinction among neighbouring points in the second catalogue is reduced, regardless of whether reference targets are present locally. Weak structures are then more apparent. The extinction of high Galactic latitude targets is more tightly correlated with the dust emission, a property acquired from the first catalogue. A hierarchical inversion technique was applied to the two merged inter-calibrated catalogues to produce 3D extinction density maps corresponding to different volumes and maximum spatial resolution. The maximum resolution is 10pc for a 3000x3000x800pc3 volume around the Sun, and the maximum size of the maps is 10x10x0.8 kpc3 for a resolution of 50pc. Maps can be downloaded or used by means of on-line tools.Comment: 16 pages, 16 figures, to appear in Astronomy and Astrophysic

Updated Gaia-2MASS 3D maps of Galactic interstellar dust

International audienceAims. Three-dimensional (3D) maps of Galactic interstellar dust are a tool for a wide range of uses. We aim to construct 3D maps of dust extinction in the Local Arm and surrounding regions.Methods. To do this, Gaia EDR3 photometric data were combined with 2MASS measurements to derive extinction towards stars with accurate photometry and relative uncertainties on EDR3 parallaxes of less than 20%. We applied our hierarchical inversion algorithm adapted to inhomogeneous spatial distributions of target stars to this catalogue of individual extinctions.Results. We present the updated 3D dust extinction distribution and provide an estimate of the error on integrated extinctions from the Sun to each area in the 3D map. The full computational area is similar to the one of the previous DR2 map, that is to say with a 6 × 6 × 0.8 kpc3 volume around the Sun. Due to the addition of fainter target stars, the volume in which the clouds can be reconstructed has increased. Due to the improved accuracy of the parallaxes and photometric data in EDR3, extinctions among neighbouring targets are more consistent, allowing one to reach an increased contrast in the dense areas, while cavity contours are more regular. We show several comparisons with recent results on dust and star distributions. The wavy pattern around the Plane of the dust concentrations is better seen and exists over large regions. Its mean vertical peak-to-peak amplitude is of the order of 300 pc; interestingly, it is similar to the vertical period of the spectacular snail-shaped stellar kinematical pattern discovered in Gaia data.Conclusions. The Gaia EDR3 catalogue allows for a significant improvement of the extinction maps to be made, both in extent and quality. The hierarchical technique confirms its efficiency in the inversion of massive datasets. Future comparisons between 3D maps of interstellar matter and stellar distributions may help to understand which mergers or internal perturbations have shaped the Galaxy within the first 3 kpc

ESA Sea Surface Salinity Climate Change Initiative (Sea_Surface_Salinity_cci): weekly and monthly sea surface salinity products, v2.31, for 2010 to 2019

The European Space Agency (ESA) Sea Surface Salinity CCI consortium has produced global, level 4, multi-sensor Sea Surface Salinity maps covering the 2010-2019 period. This dataset collection contains Sea Surface Salinity (SSS) v2.31 data at a spatial resolution of 50km and a time resolution of 1 week. It has been spatially sampled on a 25km EASE (Equal Area Scalable Earth) grid and 1 day of time sampling. A monthly product is also available, at a spatial resolution of 25 km and a time resolution of 1 month. This has been spatially sampled on a 25 km EASE (Equal Area Scalable Earth) grid and 15 days of time sampling. In addition to salinity, information on errors are provided (see more in the user guide and product documentation available below and on the Sea Surface Salinity CCI web page)

Programming of Cardiovascular Dysfunction by Postnatal Overfeeding in Rodents.

Nutritional environment in the perinatal period has a great influence on health and diseases in adulthood. In rodents, litter size reduction reproduces the effects of postnatal overnutrition in infants and reveals that postnatal overfeeding (PNOF) not only permanently increases body weight but also affects the cardiovascular function in the short- and long-term. In addition to increased adiposity, the metabolic status of PNOF rodents is altered, with increased plasma insulin and leptin levels, associated with resistance to these hormones, changed profiles and levels of circulating lipids. PNOF animals present elevated arterial blood pressure with altered vascular responsiveness to vasoactive substances. The hearts of overfed rodents exhibit hypertrophy and elevated collagen content. PNOF also induces a disturbance of cardiac mitochondrial respiration and produces an imbalance between oxidants and antioxidants. A modification of the expression of crucial genes and epigenetic alterations is reported in hearts of PNOF animals. In vivo, a decreased ventricular contractile function is observed during adulthood in PNOF hearts. All these alterations ultimately lead to an increased sensitivity to cardiac pathologic challenges such as ischemia-reperfusion injury. Nevertheless, caloric restriction and physical exercise were shown to improve PNOF-induced cardiac dysfunction and metabolic abnormalities, drawing a path to the potential therapeutic correction of early nutritional programming