The Scientific Bases of Sustainability: Methods, Measures and Correlations

Defining and assessing sustainability of complex systems (ecosystems, production systems, territorial systems, etc.) is a crucial challenge for modern science. Several instruments are necessary to answer a lot of questions related to the interactions between man and Nature. Policy makers, businessmen, researchers, managers, environmentalists and common people need information in order to understand what is sustainability and what is the distance of their behaviours from it. Sustainability indicators have been developed with the purpose to answer all these questions.The paper presents the results of the SPIn-Eco project, a sustainability analysis of the Province of Siena (Italy). It has produced a data set that allows a practical comparison among several approaches and indicators by means of correlation analysis. Important correlations were found between Ecological Footprint and CO2 emissions as well as with the non renewable exogenous part of Emergy flow. No correlation was found between total emergy flow and total ecological footprin

An emergy evaluation of a medieval water management system: The case of the underground "Bottini" in Siena (Italy)

In the middle ages, Siena had a high population density and had to face the problem of water supply within the city walls for housing, crafts, industrial activities and fire risks. With this aim, a series of underground drifts, namely "Bottini", was built at the beginning of the 13th century and achieved a total length of 25 km in the 14th century. Bottini have been capturing rain water and conducting it from the countryside to the fountains in the city centre for centuries. Brick pavements and other structures, such as brick vaults (where necessary), guaranteed water clearness and allowed a special team of workers, "bottinieri", to move throughout the tunnels for management and maintenance. Bottini still bring 9.5 l/s of clear water. Currently water is only used to fill the fountains and is then wasted. Based on statistics on water use, we argued that the activity of maintaining Bottini is not only a good practice for the conservation of a precious cultural heritage, but could also be potentially an opportunity for improving urban ecology. In this paper, we propose to investigate the environmental impact of water use comparing Bottini with a contemporary water management system. In particular, an "emergy evaluation" was developed for providing information about the sustainability of water use, both nowadays and in the past. Preliminary results showed that Bottini have a much lower environmental impact and can be potentially reused by withdrawing water and using it for some activities - such as irrigation of gardens and playgrounds, street washing and sanitary use - within the historical centre of Siena

Sub-National Scale Initiatives for Climate Change Mitigation: Refining the Approach to Increase the Effectiveness of the Covenant of Mayors

Climate change mitigation strategies include sub-national initiatives proposed and operated by municipalities. An example of such initiatives is the Covenant of Mayors, the signatories of which are requested to compile territorial greenhouse gas emission inventories to identify entry points for mitigating policies and to be able to monitor their effectiveness over time. However, the current accounting approach presents some limitations, providing an incomplete picture of the territorial emissive status, thus hampering the mitigation potential of the set of measures. The present study shows that the current approach required by the Sustainable Energy and Climate Action Plan (SECAP) guidelines for compiling the Baseline Emission Inventory (BEI) can be complemented with the accounting guidelines proposed by the Intergovernmental Panel on Climate Change (IPCC) in order to fill existing gaps and provide a comprehensive picture from a different point of view. The proposed refinement demonstrates that local administrative bodies can count on a tool able to provide detailed and accurate information, stimulate knowledge and awareness, and optimize local mitigation efforts sometimes limited by the application of large scale (national) top-down initiatives

Successful treatment of recurrent small bowel adenocarcinoma by cytoreductive surgery and chemotherapy: a case report and review of the literature

<p>Abstract</p> <p>Introduction</p> <p>Small bowel adenocarcinoma is a rare malignancy associated with a poor prognosis and there is little evidence of effective treatment. Recurrent small bowel adenocarcinoma is an intractable disease for which there is little information available regarding its treatment by palliative therapy. We present a case of recurrent small bowel adenocarcinoma successfully treated by cytoreductive surgery and palliative chemotherapy.</p> <p>Case presentation</p> <p>We report the case of a 72-year-old Japanese female who developed a peritoneal metastasis from recurrent small bowel adenocarcinoma after curative resection and adjuvant chemotherapy with S-1 and polysaccharide K. She underwent cytoreductive surgery followed by chemotherapy with folinic acid/fluorouracil/oxaliplatin and folinic acid/fluorouracil/irinotecan with polysaccharide K. Subsequently, no sign of a recurrence was observed 42 months after the second operation.</p> <p>Conclusion</p> <p>To the best of our knowledge, this is the first case report of the successful treatment of peritoneal metastasis from small bowel adenocarcinoma by cytoreductive surgery and combination chemotherapy (folinic acid/fluorouracil/oxaliplatin and folinic acid/fluorouracil/irinotecan with polysaccharide K).</p

Tracker Operation and Performance at the Magnet Test and Cosmic Challenge

During summer 2006 a fraction of the CMS silicon strip tracker was operated in a comprehensive slice test called the Magnet Test and Cosmic Challenge (MTCC). At the MTCC, cosmic rays detected in the muon chambers were used to trigger the readout of all CMS sub-detectors in the general data acquisition system and in the presence of the 4 T magnetic field produced by the CMS superconducting solenoid. This document describes the operation of the Tracker hardware and software prior, during and after data taking. The performance of the detector as resulting from the MTCC data analysis is also presented

Pain in platin-induced neuropathies: A systematic review and meta-analysis

INTRODUCTION: Platin-induced peripheral neuropathy (PIPN) is a common cause of PN in cancer patients. The aim of this paper is to systematically review the current literature regarding PIPN, with a particular focus on epidemiological and clinical characteristics of painful PIPN, and to discuss relevant management strategies. METHODS: A systematic computer-based literature search was conducted on the PubMed database. RESULTS: This search strategy resulted in the identification of 353 articles. After the eligibility assessment, 282 articles were excluded. An additional 24 papers were identified by scanning the reference lists. In total, 95 papers met the inclusion criteria and were used for this review. The prevalence of neuropathic symptoms due to acute toxicity of oxaliplatin was estimated at 84.6%, whereas PN established after chemotherapy with platins was estimated at 74.9%. Specifically regarding pain, the reported prevalence of pain due to acute toxicity of oxaliplatin was estimated at 55.6%, whereas the reported prevalence of chronic peripheral neuropathic pain in PIPN was estimated at 49.2%. CONCLUSION: Peripheral neuropathy is a common complication in patients receiving platins and can be particularly painful. There is significant heterogeneity among studies regarding the method for diagnosing peripheral neuropathy. Nerve conduction studies are the gold standard and should be performed in patients receiving platins and complaining of neuropathic symptoms post-treatment

CMS physics technical design report : Addendum on high density QCD with heavy ions

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