1,553 research outputs found
Metallicity inhomogeneities in local star-forming galaxies as sign of recent metal-poor gas accretion
We measure the oxygen metallicity of the ionized gas along the major axis of
seven dwarf star-forming galaxies. Two of them, SDSSJ1647+21 and SDSSJ2238+14,
show 0.5 dex metallicity decrements in inner regions with enhanced
star-formation activity. This behavior is similar to the metallicity drop
observed in a number of local tadpole galaxies by Sanchez Almeida et al. (2013)
and interpreted as showing early stages of assembling in disk galaxies, with
the star formation sustained by external metal-poor gas accretion. The
agreement with tadpoles has several implications: (1) it proves that galaxies
other than the local tadpoles present the same unusual metallicity pattern. (2)
Our metallicity inhomogeneities were inferred using the direct method, thus
discarding systematic errors usually attributed to other methods. (3) Taken
together with the tadpole data, our findings suggest a threshold around one
tenth the solar value for the metallicity drops to show up. Although galaxies
with clear metallicity drops are rare, the physical mechanism responsible for
them may sustain a significant part of the star-formation activity in the local
Universe. We argue that the star-formation dependence of the mass-metallicity
relationship, as well as other general properties followed by most local disk
galaxies, are naturally interpreted as side effects of pristine gas infall.
Alternatives to the metal poor gas accretion are examined too.Comment: Accepted for publication in ApJ. 10 pages. 5 Fig
The influence of prior VATS experience in the learning curvefor single-port VATS lobectomy: a multicenter comparative study
OBJECTIVES: Competency in VATS lobectomy is estimated to be complete after 50 cases. We aimed to exÂŹplore the impact of previous multiport VATS lobectomy competency in completing this workÂŹload of Single-Port procedures ...postprin
The major upgrade of the MAGIC telescopes, Part II: A performance study using observations of the Crab Nebula
MAGIC is a system of two Imaging Atmospheric Cherenkov Telescopes located in
the Canary island of La Palma, Spain. During summer 2011 and 2012 it underwent
a series of upgrades, involving the exchange of the MAGIC-I camera and its
trigger system, as well as the upgrade of the readout system of both
telescopes. We use observations of the Crab Nebula taken at low and medium
zenith angles to assess the key performance parameters of the MAGIC stereo
system. For low zenith angle observations, the standard trigger threshold of
the MAGIC telescopes is ~50GeV. The integral sensitivity for point-like sources
with Crab Nebula-like spectrum above 220GeV is (0.66+/-0.03)% of Crab Nebula
flux in 50 h of observations. The angular resolution, defined as the sigma of a
2-dimensional Gaussian distribution, at those energies is < 0.07 degree, while
the energy resolution is 16%. We also re-evaluate the effect of the systematic
uncertainty on the data taken with the MAGIC telescopes after the upgrade. We
estimate that the systematic uncertainties can be divided in the following
components: < 15% in energy scale, 11-18% in flux normalization and +/-0.15 for
the energy spectrum power-law slope.Comment: 21 pages, 25 figures, accepted for publication in Astroparticle
Physic
Multi-Wavelength Observations of the Blazar 1ES 1011+496 in Spring 2008
The BL Lac object 1ES 1011+496 was discovered at Very High Energy gamma-rays
by MAGIC in spring 2007. Before that the source was little studied in different
wavelengths. Therefore a multi-wavelength (MWL) campaign was organized in
spring 2008. Along MAGIC, the MWL campaign included the Metsahovi radio
observatory, Bell and KVA optical telescopes and the Swift and AGILE
satellites. MAGIC observations span from March to May, 2008 for a total of 27.9
hours, of which 19.4 hours remained after quality cuts. The light curve showed
no significant variability. The differential VHE spectrum could be described
with a power-law function. Both results were similar to those obtained during
the discovery. Swift XRT observations revealed an X-ray flare, characterized by
a harder when brighter trend, as is typical for high synchrotron peak BL Lac
objects (HBL). Strong optical variability was found during the campaign, but no
conclusion on the connection between the optical and VHE gamma-ray bands could
be drawn. The contemporaneous SED shows a synchrotron dominated source, unlike
concluded in previous work based on nonsimultaneous data, and is well described
by a standard one zone synchrotron self Compton model. We also performed a
study on the source classification. While the optical and X-ray data taken
during our campaign show typical characteristics of an HBL, we suggest, based
on archival data, that 1ES 1011+496 is actually a borderline case between
intermediate and high synchrotron peak frequency BL Lac objects.Comment: 13 pages, accepted for publication in MNRA
Probing the very-high-energy gamma-ray spectral curvature in the blazar PG 1553+113 with the MAGIC telescopes
PG 1553+113 is a very-high-energy (VHE, ) -ray
emitter classified as a BL Lac object. Its redshift is constrained by
intergalactic absorption lines in the range . The MAGIC telescopes
have monitored the source's activity since 2005. In early 2012, PG 1553+113 was
found in a high-state, and later, in April of the same year, the source reached
its highest VHE flux state detected so far. Simultaneous observations carried
out in X-rays during 2012 April show similar flaring behaviour. In contrast,
the -ray flux at observed by Fermi-LAT is
compatible with steady emission. In this paper, a detailed study of the flaring
state is presented. The VHE spectrum shows clear curvature, being well fitted
either by a power law with an exponential cut-off or by a log-parabola. A
simple power-law fit hypothesis for the observed shape of the PG 1553+113 VHE
-ray spectrum is rejected with a high significance (fit probability
P=2.6 ). The observed curvature is compatible with the
extragalactic background light (EBL) imprint predicted by current generation
EBL models assuming a redshift . New constraints on the redshift are
derived from the VHE spectrum. These constraints are compatible with previous
limits and suggest that the source is most likely located around the optical
lower limit, , based on the detection of Ly absorption. Finally,
we find that the synchrotron self-Compton (SSC) model gives a satisfactory
description of the observed multi-wavelength spectral energy distribution
during the flare.Comment: 13 pages, 7 figures, accepted for publication in MNRA
Interactions of KidâKis toxinâantitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of KidâKis oligomers
The parD operon of Escherichia coli plasmid R1 encodes a toxinâantitoxin system, which is involved in plasmid stabilization. The toxin Kid inhibits cell growth by RNA degradation and its action is neutralized by the formation of a tight complex with the antitoxin Kis. A fascinating but poorly understood aspect of the kidâkis system is its autoregulation at the transcriptional level. Using macromolecular (tandem) mass spectrometry and DNA binding assays, we here demonstrate that Kis pilots the interaction of the KidâKis complex in the parD regulatory region and that two discrete Kis-binding regions are present on parD. The data clearly show that only when the Kis concentration equals or exceeds the Kid concentration a strong cooperative effect exists between strong DNA binding and Kid(2)âKis(2)âKid(2)âKis(2) complex formation. We propose a model in which transcriptional repression of the parD operon is tuned by the relative molar ratio of the antitoxin and toxin proteins in solution. When the concentration of the toxin exceeds that of the antitoxin tight Kid(2)âKis(2)âKid(2) complexes are formed, which only neutralize the lethal activity of Kid. Upon increasing the Kis concentration, (Kid(2)âKis(2))(n) complexes repress the kidâkis operon
Spintronics: Fundamentals and applications
Spintronics, or spin electronics, involves the study of active control and
manipulation of spin degrees of freedom in solid-state systems. This article
reviews the current status of this subject, including both recent advances and
well-established results. The primary focus is on the basic physical principles
underlying the generation of carrier spin polarization, spin dynamics, and
spin-polarized transport in semiconductors and metals. Spin transport differs
from charge transport in that spin is a nonconserved quantity in solids due to
spin-orbit and hyperfine coupling. The authors discuss in detail spin
decoherence mechanisms in metals and semiconductors. Various theories of spin
injection and spin-polarized transport are applied to hybrid structures
relevant to spin-based devices and fundamental studies of materials properties.
Experimental work is reviewed with the emphasis on projected applications, in
which external electric and magnetic fields and illumination by light will be
used to control spin and charge dynamics to create new functionalities not
feasible or ineffective with conventional electronics.Comment: invited review, 36 figures, 900+ references; minor stylistic changes
from the published versio
Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV
A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay
channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7
TeV is presented. The data were collected at the LHC, with the CMS detector,
and correspond to an integrated luminosity of 4.6 inverse femtobarns. No
significant excess is observed above the background expectation, and upper
limits are set on the Higgs boson production cross section. The presence of the
standard model Higgs boson with a mass in the 270-440 GeV range is excluded at
95% confidence level.Comment: Submitted to JHE
Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea
Background Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there is a paucity of evidence on the efficacy of NIV in patients with OHS without severe OSA. We performed a multicentre randomised clinical trial to determine the comparative efficacy of NIV versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO2) as the main outcome measure. Methods Between May 2009 and December 2014 we sequentially screened patients with OHS without severe OSA. Participants were randomised to NIV versus lifestyle modification and were followed for 2 months. Arterial blood gas parameters, clinical symptoms, health-related quality of life assessments, polysomnography, spirometry, 6-min walk distance test, blood pressure measurements and healthcare resource utilisation were evaluated. Statistical analysis was performed using intention-to-treat analysis. Results A total of 365 patients were screened of whom 58 were excluded. Severe OSA was present in 221 and the remaining 86 patients without severe OSA were randomised. NIV led to a significantly larger improvement in PaCO2 of -6 (95% CI -7.7 to -4.2) mm Hg versus -2.8 (95% CI -4.3 to -1.3) mm Hg, (p<0.001) and serum bicarbonate of -3.4 (95% CI -4.5 to -2.3) versus -1 (95% CI -1.7 to -0.2 95% CI) mmol/L (p<0.001). PaCO2 change adjusted for NIV compliance did not further improve the inter-group statistical significance. Sleepiness, some health-related quality of life assessments and polysomnographic parameters improved significantly more with NIV than with lifestyle modification. Additionally, there was a tendency towards lower healthcare resource utilisation in the NIV group. Conclusions NIV is more effective than lifestyle modification in improving daytime PaCO2, sleepiness and polysomnographic parameters. Long-term prospective studies are necessary to determine whether NIV reduces healthcare resource utilisation, cardiovascular events and mortality
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