Trois bibliothécaires des Lumières et leur participation à la constitution de bibliothèques « bohêmes »

Personnage du bibliothécaire en Bohême à la période des Lumières, c\u27est à dire des prémices de l\u27éveil national à travers trois portraits symboliques d\u27une génération « d’éveilleurs » (buditelé) de « patriotes ardents » (horliví vlastenci) et « d’infatigables défenseurs de la culture écrite tchèque »

Killing Innovation?: Antitrust Implications of Killer Acquisitions

Killer instinct is a key business asset. Firms live and die by their strategic choices, and the desire to outcompete rivals colors most business decisions. While many firms strive to win market share on their merits, economists have recently identified an anti-competitive practice—killer acquisition—that enables incumbents to maintain market share by burying,rather than beating, rival technologies. In these acquisitions, firms buy competitors to prevent market cannibalization, preserving profits at a price that is right for both the acquirer and the target

Standard operating procedures for the nonlinear biodynamics laboratory

After having worked in the Non-Linear Biodynamics lab for a few months, I determined that conducting original research is not where my true interests lie. Through this process, however, I learned a great deal about the equipment and systems that are key elements in the research process for projects that are conducted in this lab. A current need in the lab is a document of standard operating procedures. Such a document would have the primary purpose of smoothing the transition of new graduate students entering the lab, so they could learn the processes and basic system operation quickly in order to be up to speed with the more “veteran” members of the lab. Aside from the above primary goal, a secondary goal of writing this SOP document is to create a standardized method for the organization of research projects being conducted in the lab. This will allow for simpler archiving of major grant-funded projects, and will also provide a suitable place for other research projects that are not as formal in nature.Kinesiology and Health Educatio

Sunblazer State Determination Investigation

Investigation of estimation problem to determine methods of processing transmitted data to obtain optimum state estimation of Sunblazer solar prob

Airborne Particulate Matter at a Bus Station: Concentration Levels and Governing Parameters

Traffic emissions are an important contributor to ambient air pollution, especially in large cities featuring extensive and high density traffic networks. Bus fleets represent a significant part of inner city traffic causing an increase in exposure to general public, passengers and drivers along bus routes and at bus stations. Limited information is available on quantification of the levels, and governing parameters affecting the air pollution exposure at bus stations. The presented study investigated the bus emissions-dominated ambient air in a large, inner city bus station, with a specific focus on submicrometer particles. The study’s objectives were (i) quantification of the concentration levels; (ii) characterisation of the spatio-temporal variation; (iii) identification of the parameters governing the emissions levels at the bus station and (iv) assessment of the relationship between particle concentrations measured at the street level (background) and within the bus station. The results show that up to 90% of the emissions at the station are ultrafine particles (smaller than 100 nm), with the concentration levels up to 10 times the value of urban ambient air background (annual) and up to 4 times the local ambient air background. The governing parameters affecting particle concentration at the station were bus flow rate and meteorological conditions (wind velocity). Particle concentration followed a diurnal trend, with an increase in the morning and evening, associated with traffic rush hours. Passengers’ exposure could be significant compared to the average outdoor and indoor exposure levels

Brain regions show different metabolic and protein arginine methylation phenotypes in frontotemporal dementias and Alzheimer's disease

Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disease with multiple histopathological subtypes. FTD patients share similar symptoms with Alzheimer's disease (AD). Hence, FTD patients are commonly misdiagnosed as AD, despite the consensus clinical diagnostic criteria. It is therefore of great clinical need to identify a biomarker that can distinguish FTD from AD and control individuals, and potentially further differentiate between FTD pathological subtypes. We conducted a metabolomic analysis on post-mortem human brain tissue from three regions: cerebellum, frontal cortex and occipital cortex from control, FTLD-TDP type A, type A-C9, type C and AD. Our results indicate that the brain subdivisions responsible for different functions show different metabolic patterns. We further explored the region-specific metabolic characteristics of different FTD subtypes and AD patients. Different FTD subtypes and AD share similar metabolic phenotypes in the cerebellum, but AD exhibited distinct metabolic patterns in the frontal and occipital regions compared to FTD. The identified brain region-specific metabolite biomarkers could provide a tool for distinguishing different FTD subtypes and AD and provide the first insights into the metabolic changes of FTLD-TDP type A, type A-C9, type C and AD in different regions of the brain. The importance of protein arginine methylation in neurodegenerative disease has come to light, so we investigated whether the arginine methylation level contributes to disease pathogenesis. Our findings provide new insights into the relationship between arginine methylation and metabolic changes in FTD subtypes and AD that could be further explored, to study the molecular mechanism of pathogenesis