Exploring the social innovation co-production nexus in Sofia: The case of Toplocentrala within the AGORA project

This paper investigates the territorial implications of social innovation and co-production of services in strategic spatial planning. It focuses on the regeneration of Toplocentrala, a socialist heritage building in Sofia that has been transformed into a regional centre for contemporary arts, within the context of the AGORA project’s strategic planning process. The research aims to enhance our understanding of the role of public action in social innovation and the need to redefine collaborative practices within institutional frameworks to promote innovation. A multi-method approach combining qualitative and quantitative data was employed, including site visits, interviews with key stakeholders, and secondary data analysis. The study highlights how strategic spatial planning processes involving social innovation and co-production of services can reshape the relationship between the state and civil society

La investigación formativa en ciencias empresariales: .Experiencias de investigación formativa POLIPIF

El material propuesto en el libro resume gran parte de la calidad de los trabajos presentados y la evolución en el desarrollo de las capacidades de los estudiantes en un contexto actual, complejo y retador, que refleja la realidad de las organizaciones actuales sobre escenarios estratégicos y manejo de situaciones complejas, para que, cuando lleguen a ser empleados o emprendedores, sepan afrontar cada paso hacia el cambio

American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus

10.1002/acr.23834ARTHRITIS CARE & RESEARCH715579-59

Global variations in diabetes mellitus based on fasting glucose and haemogloblin A1c

Fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) are both used to diagnose diabetes, but may identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening had elevated FPG, HbA1c, or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardised proportion of diabetes that was previously undiagnosed, and detected in survey screening, ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the agestandardised proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global gap in diabetes diagnosis and surveillance.peer-reviewe

Reseñas de libros

Montes Serrano, Carlos. Cicerón y la cultura artística del Renacimiento (Por Alberto Grijalba Bengoetxea) pp.4-5.-- Casado de Amezúa V.ázquez, Joaquín.La unidad temática. Aproximación a un modelo de intervención en la ciudad construida (Por Antonio J. Gómez-Blanco Pontes) pp. 5.6.-- Granero Martín, Francisco. Agua y territorio. Arquitectura y paisaje (Por Carlos Montes Serrano) pp.6-7.-- Gámiz Gordo, Antonio. Cinco grabados de Vejer (siglos XVI-XVIII). Estudio crítico (Por Eduardo Mosquera Adell) pp. 8-9.-- Bellido Blanco, Santiago. El río Duero, un análisis gráfico arquitectónico. Influencia del entorno natural en la conformación del paisaje humanizado (Por Fernando Linares García) pp.9-10.-- Esteve Secall, Carlos. El cuadrante solar del Real Monasterio de San Jerónimo de Granada (Por Joaquin Casado de Amezúa) pp.10-11.-- Navarro Fajardo, Juan Carlos. Bóvedas de la arquitectura gótica valenciana. Traza V montea (Por .Jorge llopis Verdú) pp.11-12.-- Puebla Pons, Juan. La iconografía del modelo (Por Jaime Sanmartí Verdaguer) pp. 13.-- Cabanes Ginés, José Luis. Geometría Proyectiva y Representación Técnica (Por Pablo Navarro Esteve) pp.14.-- Herrero Rey, Almudena. Tratadística inglesa de arquitectura, 1563-1664 pp.15.-- Albareda Mussons, Antonio. Del espacio del cómic al espacio pp.16.-- Bruscato Portella, Underlea. De lo digital en arquitectura cinematográfico pp.17-18.-- Cabanes Ginés, José Luis. Rectificación fotogramétrica de objetos planos por métodos gráficos basados en principios proyectivos pp.18.-- I Congreso Iberoamericano Expresión Gráfica Arquitectónica en México. EGA MEXICO 2006 (Por Enrique Solana Suárez) pp.19-20.-- La iconografía del modelo (Por Juan Puebla fons) pp.21.-- En recuerdo de Emilio Díaz Martínez (Por J.M. Gentíl ) pp.22.--Grijalba Bengoetxea, A.; Gómez-Blanco Pontes, AJ.; Montes Serrano, C.; Mosquera Adell, E.; Linares García, F.; Casado De Amezúa, J.; Llopis Verdú, J.... (2007). Reseñas de libros. EGA Expresión Gráfica Arquitectónica. 12(12):4-23. https://doi.org/10.4995/ega.2007.10287OJS423121

I Plan de igualdade entre mulleres e homes no Servizo Galego de Saúde. Período 2021-2024

I Plan de Igualdade entre mulleres e homes no Servizo Galego de Saúde, período 2021-2024, definido como un conxunto ordenado de medidas adoptadas despois de realizar un diagnóstico de situación, tendentes a alcanzar na organización a igualdade de trato e de oportunidades entre mulleres e homes e a eliminar a discriminación por razón de sexo.I Plan de Igualdad entre mujeres y hombres en el Servicio Gallego de Salud, período 2021-2024, definido como un conjunto ordenado de medidas adoptadas después de realizar un diagnóstico de situación, tendentes a alcanzar en la organización la igualdad de trato y de oportunidades entre mujeres y hombres y a eliminar la discriminación por razón de sexo

American college of rheumatology provisional criteria for clinically relevant improvement in children and adolescents with childhood-onset systemic Lupus erythematosus

To develop a Childhood Lupus Improvement Index (CHILI) as a tool to measure response to therapy in childhood-onset systemic lupus erythematosus (cSLE), with a focus on clinically relevant improvement (CRIcSLE). Methods Pediatric nephrology and rheumatology subspecialists (n = 213) experienced in cSLE management were invited to define CRIcSLE and rate a total of 433 unique patient profiles for the presence/absence of CRIcSLE. Patient profiles included the following cSLE core response variables (CRVs): global assessment of patient well-being (patient-global), physician assessment of cSLE activity (MD-global), disease activity index score (here, we used the Systemic Lupus Erythematosus Disease Activity Index), urine protein-to-creatinine ratio, and Child Health Questionnaire physical summary score. Percentage and absolute changes in these cSLE-CRVs (baseline versus follow-up) were considered in order to develop candidate algorithms and validate their performance (sensitivity, specificity, area under the receiver operating characteristic curve [AUC]; range 0-1). Results During an international consensus conference, unanimous agreement on a definition of CRIcSLE was achieved; cSLE experts (n = 13) concurred (100%) that the preferred CHILI algorithm considers absolute changes in the cSLE-CRVs. After transformation to a range of 0-100, a CHILI score of >= 54 had outstanding accuracy for identifying CRIcSLE (AUC 0.93, sensitivity 81.1%, and specificity 84.2%). CHILI scores also reflect minor, moderate, and major improvement for values exceeding 15, 68, and 92, respectively (all AUC >= 0.92, sensitivity >= 93.1%, and specificity >= 73.4%). Conclusion The CHILI is a new, seemingly highly accurate index for measuring CRI in cSLE over time. This index is useful to categorize the degree of response to therapy in children and adolescents with cSLE.715579590CNPQ - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulo303422/2015-7; 7/2016-9; 304255/2015-7215/03756-

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

International audienceAbstract Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

: Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit