745 research outputs found

    Building a spreadsheet model.

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    Evolving Lorentzian Wormholes

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    Evolving Lorentzian wormholes with the required matter satisfying the Energy conditions are discussed. Several different scale factors are used and the corresponding consequences derived. The effect of extra, decaying (in time) compact dimensions present in the wormhole metric is also explored and certain interesting conclusions are derived for the cases of exponential and Kaluza--Klein inflation.Comment: 10 pages( RevTex, Twocolumn format), Two figures available on request from the first author. transmission errors corrected

    On the eigenvalues of Cayley graphs on the symmetric group generated by a complete multipartite set of transpositions

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    Given a finite simple graph \cG with nn vertices, we can construct the Cayley graph on the symmetric group SnS_n generated by the edges of \cG, interpreted as transpositions. We show that, if \cG is complete multipartite, the eigenvalues of the Laplacian of \Cay(\cG) have a simple expression in terms of the irreducible characters of transpositions, and of the Littlewood-Richardson coefficients. As a consequence we can prove that the Laplacians of \cG and of \Cay(\cG) have the same first nontrivial eigenvalue. This is equivalent to saying that Aldous's conjecture, asserting that the random walk and the interchange process have the same spectral gap, holds for complete multipartite graphs.Comment: 29 pages. Includes modification which appear on the published version in J. Algebraic Combi

    The EBV-encoded oncoprotein, LMP1, induces an epithelial-to-mesenchymal transition (EMT) via Its CTAR1 domain through integrin-mediated ERK-MAPK signalling

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    The Epstein⁻Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) oncogene can induce profound effects on epithelial growth and differentiation including many of the features of the epithelial-to-mesenchymal transition (EMT). To better characterise these effects, we used the well-defined Madin Darby Canine Kidney (MDCK) epithelial cell model and found that LMP1 expression in these cells induces EMT as defined by characteristic morphological changes accompanied by loss of E-cadherin, desmosomal cadherin and tight junction protein expression. The induction of the EMT phenotype required a functional CTAR1 domain of LMP1 and studies using pharmacological inhibitors revealed contributions from signalling pathways commonly induced by integrin⁻ligand interactions: extracellular signal-regulated kinases/mitogen-activated protein kinases (ERK-MAPK), PI3-Kinase and tyrosine kinases, but not transforming growth factor beta (TGFβ). More detailed analysis implicated the CTAR1-mediated induction of Slug and Twist in LMP1-induced EMT. A key role for β1 integrin signalling in LMP1-mediated ERK-MAPK and focal adhesion kianse (FAK) phosphorylation was observed, and β1 integrin activation was found to enhance LMP1-induced cell viability and survival. These findings support an important role for LMP1 in disease pathogenesis through transcriptional reprogramming that enhances tumour cell survival and leads to a more invasive, metastatic phenotype

    Towards the statistical detection of the warm-hot intergalactic medium in intercluster filaments of the cosmic web.

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    Modern analyses of structure formation predict a universe tangled in a ‘cosmic web’ of dark matter and diffuse baryons. These theories further predict that at low z, a significant fraction of the baryons will be shock-heated to T ∼ 105–107 K yielding a warm–hot intergalactic medium (WHIM), but whose actual existence has eluded a firm observational confirmation. We present a novel experiment to detect the WHIM, by targeting the putative filaments connecting galaxy clusters. We use HST/COS to observe a remarkable quasi-stellar object (QSO) sightline that passes within Δd = 3 Mpc from the seven intercluster axes connecting seven independent cluster pairs at redshifts 0.1 ≤ z ≤ 0.5. We find tentative excesses of total H I, narrow H I (NLA; Doppler parameters b < 50 km s−1), broad H I (BLA; b ≥ 50 km s−1) and O VI absorption lines within rest-frame velocities of Δv ≲ 1000 km s−1 from the cluster-pairs redshifts, corresponding to ∼2, ∼1.7, ∼6 and ∼4 times their field expectations, respectively. Although the excess of O VI likely comes from gas close to individual galaxies, we conclude that most of the excesses of NLAs and BLAs are truly intergalactic. We find the covering fractions, fc, of BLAs close to cluster pairs are ∼4–7 times higher than the random expectation (at the ∼2σ c.l.), whereas the fc of NLAs and O VI are not significantly enhanced. We argue that a larger relative excess of BLAs compared to those of NLAs close to cluster pairs may be a signature of the WHIM in intercluster filaments. By extending this analysis to tens of sightlines, our experiment offers a promising route to detect the WHIM

    On the warp drive space-time

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    In this paper the problem of the quantum stability of the two-dimensional warp drive spacetime moving with an apparent faster than light velocity is considered. We regard as a maximum extension beyond the event horizon of that spacetime its embedding in a three-dimensional Minkowskian space with the topology of the corresponding Misner space. It is obtained that the interior of the spaceship bubble becomes then a multiply connected nonchronal region with closed timelike curves and that the most natural vacuum allows quantum fluctuations which do not induce any divergent behaviour of the re-normalized stress-energy tensor, even on the event (Cauchy) chronology horizon. In such a case, the horizon encloses closed timelike curves only at scales close to the Planck length, so that the warp drive satisfies the Ford's negative energy-time inequality. Also found is a connection between the superluminal two-dimensional warp drive space and two-dimensional gravitational kinks. This connection allows us to generalize the considered Alcubierre metric to a standard, nonstatic metric which is only describable on two different coordinate patchesComment: 7 pages, minor comment on chronology protection added, RevTex, to appear in Phys. Rev.

    On the connection between the intergalactic medium and galaxies: the H I–galaxy cross-correlation at z ≲ 1

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    We present a new optical spectroscopic survey of 1777 ‘star-forming’ (‘SF’) and 366 ‘non-star-forming’ (‘non-SF’) galaxies at redshifts z ∼ 0-1 (2143 in total), 22 AGN and 423 stars, observed by instruments such as the Deep Imaging Multi-Object Spectrograph, the Visible Multi-Object Spectrograph and the Gemini Multi-Object Spectrograph, in three fields containing five quasi-stellar objects (QSOs) with Hubble Space Telescope (HST) ultraviolet spectroscopy. We also present a new spectroscopic survey of 173 ‘strong’ (1014 ≤ NHI≲ 1017 cm−2) and 496 ‘weak’ (1013 ≲ NHI 50 per cent of ‘weak’ H i systems reside within galaxy voids (hence not correlated with galaxies), and are confined in dark matter haloes of masses smaller than those hosting ‘strong’ systems and/or galaxies. We speculate that H i systems within galaxy voids might still be evolving in the linear regime even at scales ≲2 Mpc

    Properties of pattern formation and selection processes in nonequilibrium systems with external fluctuations

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    We extend the phase field crystal method for nonequilibrium patterning to stochastic systems with external source where transient dynamics is essential. It was shown that at short time scales the system manifests pattern selection processes. These processes are studied by means of the structure function dynamics analysis. Nonequilibrium pattern-forming transitions are analyzed by means of numerical simulations.Comment: 15 poages, 8 figure

    How transparent are central banks?

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    Central bank transparency has become the topic of a lively public and academic debate on monetary policy. However, this has been complicated by the fact that transparency is a qualitative concept that is hard to measure. This paper proposes an index for the transparency of monetary policy that comprises the political, economic, procedural, policy and operational aspects of central banking. The index is compiled for nine major central banks. It is based on a detailed analysis of actual information disclosure and reveals a rich variety in the degree and dynamics of central bank transparency
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