From Corporate Social Responsibility to Accountability Mechanisms:The Role of the Convention on Biological Diversity

This paper traces the progressive shift at the international level from purely voluntary approaches (corporate social responsibility or CSR) towards accountability mechanisms to ensure the environmentally sound conduct of private entities. It examines whether the most recent international discussion on human rights and corporate accountability have adequately considered environmental protection concerns. It then concentrates on the growing number of international oversight mechanisms that provide a readily-available and impartial avenue for addressing complaints against private companies..

Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study

Background & AimsIn acute liver failure, severity of liver injury and clinical progression of disease are in part consequent upon activation of the innate immune system. Endotoxaemia contributes to innate immune system activation and the detoxifying function of albumin, critical to recovery from liver injury, is irreversibly destroyed in acute liver failure. University College London-Liver Dialysis Device is a novel artificial extracorporeal liver assist device, which is used with albumin infusion, to achieve removal and replacement of dysfunctional albumin and reduction in endotoxaemia. We aimed to test the effect of this device on survival in a pig model of acetaminophen-induced acute liver failure.MethodsPigs were randomised to three groups: Acetaminophen plus University College London-Liver Dialysis Device (n=9); Acetaminophen plus Control Device (n=7); and Control plus Control Device (n=4). Device treatment was initiated two h after onset of irreversible acute liver failure.ResultsThe Liver Dialysis Device resulted in 67% reduced risk of death in acetaminophen-induced acute liver failure compared to Control Device (hazard ratio=0.33, p=0.0439). This was associated with 27% decrease in circulating irreversibly oxidised human non-mercaptalbumin-2 throughout treatment (p=0.046); 54% reduction in overall severity of endotoxaemia (p=0.024); delay in development of vasoplegia and acute lung injury; and delay in systemic activation of the TLR4 signalling pathway. Liver Dialysis Device-associated adverse clinical effects were not seen.ConclusionsThe survival benefit and lack of adverse effects would support clinical trials of University College London-Liver Dialysis Device in acute liver failure patients

Human Rights and the environment : the interdependence of human rights and a healthy environment in the context of national legislation on natural resources

This legal paper reflects on the evolution of international law on the interdependence of human rights and the environment. It illustrates their significance for the development and implementation of national laws on agricultural development and the management of renewable natural resources, ranging from land, water, fisheries, plants, and animals, to food, forestry, wildlife, biodiversity and trade laws. It is also relevant for national laws on climate change, gender equality, agribusiness operations, the right to food, the right to water and the prevention of potential conflicts arising from the competition for natural resources. The paper brings together lessons learned through the mandate of the former United Nations Special Rapporteur on human rights and the environment, John H. Knox, and academic research on international biodiversity law and human rights, by Elisa Morgera. The Paper gives an overview of the increasing cross-fertilization between international environmental law and international human rights law. It looks specifically at nature conservation and the human rights of Indigenous Peoples. It also focuses on other areas of the nexus between human rights and biodiversity that are of particular relevance to national laws on natural resource

nanoscale characterisation of hybrid photovoltaic cells based on c61 capped cdse qds

Hybrid solar cells based on 1,2 methanofullerene (C61) capped CdSe and poly (3-hexylthiophene) (P3HT) were been investigated through a range of techniques. High resolution transmission electron microscopy (HRTEM) was used to characterize size, morphology and crystal structure of as-grown and C61-capped CdSe quantum dots. Cross sectional lamellar specimens were prepared from full photovoltaic devices using a focused ion beam milling approach. The sections were analysed by high angle annular dark field imaging in scanning TEM mode to determine the morphology of the device, in particular the intermixing of P3HT and capped quantum dots

Improving the eco-efficiency of an agricultural water use system

During the last two decades, the concept of eco-efficiency has been recognized as a suitable measure of progress towards a greener and more sustainable economy. The prefix “eco-” refers to both economic and ecological (environmental) performance. The need for improving eco-efficiency leads to the challenge of identifying the most promising alternative solutions which improve both the economic and the environmental performance of a given system (“eco-innovations”). Therefore, it becomes critical to develop eco-efficiency metrics for measuring environmental and economic performance of a system. The current paper presents a methodological framework that attempts to explore the use of eco-efficiency indicators in meso-level water use systems and through them to assess the impact of innovative technologies in such systems. The assessment of the environmental performance follows a life-cycle oriented approach using the midpoint impact categories while the economic performance is measured using the Total Value Added to the product due to water use. The eco-efficiency is expressed as the ratio of the economic performance indicator to the environmental performance indicator. The proposed approach is applied to a water use system of the agricultural sector, and more specifically to the fresh form tomato crop production in Phthiotida. The analysis reveals that the most important environmental impacts of the system are (i) greenhouse gas emissions due to energy consumption, (ii) release of toxic substances, due to the use of fertilizers and pesticides and (iii) depletion of freshwater resources. Three alternative interventions are examined for upgrading the value chain: (i) installation of sub-surface drip irrigation system, (ii) replacement of diesel pumps with solar pumps and (iii) use of organic fertilizers. Based on the findings, all of the proposed interventions have a positive impact on the overall eco-efficiency of the system. Sub-surface drip irrigation is the least favorable mainly due to its high investment cost. The use of solar pumps strongly influences climate change and photochemical ozone formation while the use of organic fertilizers has a more balanced impact on all indicators, with an emphasis on eutrophication. Thus, for a more holistic approach, regarding the eco-efficiency performance, a combined application of these three scenarios may be proposed

Magnesium lactate in the treatment of Gitelman syndrome: patient-reported outcomes.

BACKGROUND: Gitelman syndrome (GS) is a rare recessively inherited renal tubulopathy associated with renal potassium (K) and magnesium (Mg) loss. It requires lifelong K and Mg supplementation at high doses that are at best unpalatable and at worst, intolerable. In particular, gastrointestinal side effects often limit full therapeutic usage. METHODS: We report here the analysis of a cohort of 28 adult patients with genetically proven GS who attend our specialist tubular disorders clinic, in whom we initiated the use of a modified-release Mg preparation (slow-release Mg lactate) and who were surveyed by questionnaire. RESULTS: Twenty-five patients (89%) preferred the new treatment regimen. Of these 25, 17 (68%) regarded their symptom burden as improved and seven reported no worsening. Of the 25 who were not Mg-treatment naïve, 13 (59%) patients reported fewer side effects, 7 (32%) described them as the same and only 2 (9%) considered side effects to be worse. Five were able to increase their dose without ill-effect. Overall, biochemistry improved in 91% of the 23 patients switched from therapy with other preparations who chose to continue the modified-release Mg preparation. Eleven (48%) improved both their Mg and K mean levels, 3 (13%) improved Mg levels only and in 7 cases (30%), K levels alone rose. CONCLUSIONS: Patient-reported and biochemical outcomes using modified-release Mg supplements were very favourable, and patient choice should play a large part in choosing Mg supplements with GS patients.This work was supported by the Wellcome Trust and the NIHR Cambridge Biomedical Research Centre, and contains data that were presented in abstract form at ASN Kidney week 2014.This is the final version of the article. It first appeared from Oxford University Press via https://doi.org/10.1093/ndt/gfw01

Principles for transformative ocean governance

With a focus on oceans, we collaborated across ecological, social and legal disciplines to respond to the United Nations call for transformation in the ‘2030 Agenda for Sustainable Development’. We developed a set of 13 principles that strategically and critically connect transformative ocean research to transformative ocean governance (complementing the UN Decade for Ocean Science). We used a rigorous, iterative and transparent consensus-building approach to define the principles, which can interact in supporting, neutral or sometimes conflicting ways. We recommend that the principles could be applied as a comprehensive set and discuss how to learn from their interactions, particularly those that reveal hidden tensions. The principles can bring and keep together partnerships for innovative ocean action. This action must respond to the many calls to reform current ocean-use practices which are based on economic growth models that have perpetuated inequities and fuelled conflict and environmental decline