Propiedades psicométricas del Inventario de Situaciones y Respuestas de Ansiedad Breve (ISRA-B)

Introducción y objetivos La ansiedad es la reacción emocional más estudiada, que nos pone en alerta ante la posibilidad de obtener un resultado negativo, por lo que resulta adaptativa en la gran mayoría de las ocasiones, aunque también está en la base de los trastornos emocionales más prevalentes. Por ello, su evaluación ha generado mucha investigación y transferencia. El Inventario de Situaciones y Respuestas de Ansiedad (ISRA) fue desarrollado en España, incluye 22 situaciones (S) y 24 respuestas (R) de ansiedad, que al cruzarlas se forman 224 reactivos (del tipo «en tal S, experimento esta R»). Desde hace más de tres décadas ha sido ampliamente utilizado en la investigación, así como en la práctica, y se han publicado estudios sobre sus propiedades psicométricas en diferentes países. Una versión más breve (ISRA-B) de 46 ítems, sin contenidos cruzados S × R, sino una escala de 22 S y otra de 24 R, con las que evalúan las mismas ocho facetas de la ansiedad, ha mostrado buenas propiedades psicométricas también; sin embargo, existen menos publicaciones psicométricas en población española. El objetivo de este estudio fue analizar las propiedades psicométricas del ISRA-B en España. Método Para ello se contó con 3, 346 voluntarios (36.4% hombres), con edades de 15 a 94 años (media: 30.3; DE: 14.6). Resultados Los resultados confirmaron excelente consistencia interna para Total (.94) y subescala R (.91), buena para S (.89) y sistemas de respuesta Fisiológico (.86) y Cognitivo (.84), y aceptable para Motor (.70). También se encontró buena estabilidad test-retest al cabo de un mes (.78) y buena validez externa al correlacionar .87 con el ISRA original. La estructura factorial del ISRA-B obtenida se adecuó al modelo de Lang de tres sistemas de R y al modelo de Endler de interacción S × R, en los que se basa. Asimismo, se presentan los datos normativos, por sexo y grupo. Conclusión Se concluye que el ISRA-B es válido y confiable, mejora su aplicabilidad respecto al ISRA original, conservando sus propiedades psicométricas. Introduction and objectives: Anxiety is the most studied emotional reaction, which alerts us of the possibility of obtaining a negative result, making it adaptive in the vast majority of cases, although it is also one of the underlying factors of the most prevalent emotional disorders. Therefore, its assessment has generated a lot of research and transfer. The Inventory of Situations and Responses of Anxiety (ISRA) was developed in Spain and it includes 22 situations (S) and 24 responses (R) of anxiety, by which 224 items are formed by crossing them (i.e., «in such Situation, I experience this Reaction»). For more than three decades, it has been widely used in research and practice, and its psychometric properties have been published in different countries. A shorter, 46-item version (ISRA-B), with a 22 S scale plus another of 24 R was developed. The same eight facets of anxiety were assessed, showing good psychometric properties as well. However, there are few publications on the psychometric data using Spanish population. The objective of this study was to analyze the psychometric properties of ISRA-B in Spain. Methods: Three thousand three hundred and forty six volunteers (36.4% men), aged 15 to 94 years (mean: 30.3; SD: 14.6) were included. Results: The results confirmed excellent internal consistency for the Total (.94) and the Responses subscale (0.91), good for the Situations (0.89), as well as the Physiological (, 86) and Cognitive (0.84) response systems, and acceptable for the Motor (0.70). Good test-retest stability was also found after two months (0.78) and good external validity when correlated with the original ISRA (0.87). The results confirm the factor structure of the ISRA-B, adjusted to Lang''s triple response system model and to Endler''s S × R interaction model, on which it is based. Likewise, the normative data are presented, differentiated by sex and group. Conclusions: It is concluded that the ISRA-B is a valid and reliable instrument, which improves its applicability compared to the original ISRA by simplifying its format and number of items, while preserving its psychometric properties

Functional determinants for general self-adjoint extensions of Laplace-type operators resulting from the generalized cone

In this article we consider the zeta regularized determinant of Laplace-type operators on the generalized cone. For {\it arbitrary} self-adjoint extensions of a matrix of singular ordinary differential operators modelled on the generalized cone, a closed expression for the determinant is given. The result involves a determinant of an endomorphism of a finite-dimensional vector space, the endomorphism encoding the self-adjoint extension chosen. For particular examples, like the Friedrich's extension, the answer is easily extracted from the general result. In combination with \cite{BKD}, a closed expression for the determinant of an arbitrary self-adjoint extension of the full Laplace-type operator on the generalized cone can be obtained.Comment: 27 pages, 2 figures; to appear in Manuscripta Mathematic

Olaparib and ceralasertib (AZD6738) in patients with triple-negative advanced breast cancer: Results from Cohort E of the plasmaMATCH trial (CRUK/15/010)

Purpose: Approximately 10% to 15% of triple-negative breast cancers (TNBC) have deleterious mutations in BRCA1 and BRCA2 and may benefit from PARP inhibitor treatment. PARP inhibitors may also increase exogenous replication stress and thereby increase sensitivity to inhibitors of ataxia telangiectasia and Rad3-related (ATR) protein. This phase II study examined the activity of the combination of PARP inhibitor, olaparib, and ATR inhibitor, ceralasertib (AZD6738), in patients with advanced TNBC. Patients and Methods: Patients with TNBC on most recent biopsy who had received 1 or 2 lines of chemotherapy for advanced disease or had relapsed within 12 months of (neo)adjuvant chemotherapy were eligible. Treatment was olaparib 300 mg twice a day continuously and celarasertib 160 mg on days 1–7 on a 28-day cycle until disease progression. The primary endpoint was confirmed objective response rate (ORR). Tissue and plasma biomarker analyses were preplanned to identify predictors of response. Results: 70 evaluable patients were enrolled. Germline BRCA1/2 mutations were present in 10 (14%) patients and 3 (4%) patients had somatic BRCA mutations. The confirmed ORR was 12/70; 17.1% (95% confidence interval, 10.4–25.5). Responses were observed in patients without germline or somatic BRCA1/2 mutations, including patients with mutations in other homologous recombination repair genes and tumors with functional homologous recombination deficiency by RAD51 foci. Conclusions: The response rate to olaparib and ceralasertib did not meet prespecified criteria for activity in the overall evaluable population, but responses were observed in patients who would not be expected to respond to olaparib monotherapy

The On-orbit Calibrations for the Fermi Large Area Telescope

The Large Area Telescope (LAT) on--board the Fermi Gamma ray Space Telescope began its on--orbit operations on June 23, 2008. Calibrations, defined in a generic sense, correspond to synchronization of trigger signals, optimization of delays for latching data, determination of detector thresholds, gains and responses, evaluation of the perimeter of the South Atlantic Anomaly (SAA), measurements of live time, of absolute time, and internal and spacecraft boresight alignments. Here we describe on orbit calibration results obtained using known astrophysical sources, galactic cosmic rays, and charge injection into the front-end electronics of each detector. Instrument response functions will be described in a separate publication. This paper demonstrates the stability of calibrations and describes minor changes observed since launch. These results have been used to calibrate the LAT datasets to be publicly released in August 2009.Comment: 60 pages, 34 figures, submitted to Astroparticle Physic

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype