Factores clínicos asociados a reinfección de covid-19 en personal de salud que labora en el área covid del estado de Hidalgo

At the end of 2019, the first cases of COVID-19 began, whose causative agent is the SARS-CoV 2 virus. Since then and to date, the world continues to suffer from it and there are still many unanswered questions, for example, what are the clinical factors that favor infection and reinfection? For this, working with exposed people, such as health personnel is necessary. Objective: Identify the clinical factors that were associated with COVID-19 in Health personnel. Methodology: For this, a survey was applied to health personnel who were caring for patients with COVID-19. A total of 150 people were studied as health personnel, including 117 women and 33 men. The results showed that men were more susceptible to infection than women, comorbidities favor the symptoms of COVID-19, mostly in men; vaccination does not protect against infection by the virus; those infected are reinfected on more than one occasion and for up to six months. This work allows us to conclude that it is necessary to be more careful in men than in women in cases of COVID since it is possible that the virus will not be eliminated in several months.A finales del año 2019 comienzan los primeros casos de COVID-19 cuyo agente causal es el virus SARS-CoV 2. Desde entonces y hasta la fecha el mundo sigue padeciéndolo y aún hay muchas interrogantes sin contestar, por ejemplo ¿cuáles son los factores clínicos favorecen la infección y la reinfección? Para ello es necesario trabajar con personas expuestas, como es el personal de salud. Objetivo: Identificar los factores clínicos qué se asociaban a COVID-19 en personal de Salud. Metodología: Para ello se aplicó una encuesta al personal de salud que se encontraba atendiendo a pacientes con COVID-19. Fue un total de 150 personas estudiadas como personal de salud, entre ellos 117 mujeres y 33 hombres. Los resultados demostraron que los hombres fueron más susceptibles a la infección que las mujeres, las comorbilidades favorecen la sintomatología a  COVID-19, mayormente en los hombres; la vacunación no protege contra la infección por el virus; los infectados se reinfectan en más de una ocasión y hasta por seis meses. Este trabajo permite concluir hay que tener más cuidado en los hombres que en las mujeres en casos de COVID ya que es posible que no se elimine el virus en varios meses

Heterozygous Arrhythmogenic Cardiomyopathy-desmoplakin Mutation Carriers Exhibit a Subclinical Cutaneous Phenotype with Cell Membrane Disruption and Lack of Intercellular Adhesion

Genetic variants that result in truncation in desmoplakin (DSP) are a known cause of arrhythmogenic cardiomyopathy (AC). In homozygous carriers, the combined involvement of skin and heart muscle is well defined, however, this is not the case in heterozygous carriers. The aim of this work is to describe cutaneous findings and analyze the molecular and ultrastructural cutaneous changes in this group of patients. Four women and eight men with a mean age of 48 ± 14 years were included. Eight met definitive criteria for AC, one was borderline and three were silent carriers. No relevant macroscopic changes in skin and hair were detected. However, significantly lower skin temperature (29.56 vs. 30.97 ◦C, p = 0.036) and higher transepidermal water loss (TEWL) (37.62 vs. 23.95 g m 2 h 1, p = 0.028) were observed compared to sex- and age-matched controls. Histopathology of the skin biopsy showed widening of intercellular spaces and acantholysis of keratinocytes in the spinous layer. Immunohistochemistry showed a strongly reduced expression of DSP in all samples. Trichogram showed regular nodules (thickening) compatible with pseudomonilethrix. Therefore, regardless of cardiac involvement, heterozygous patients with truncation-type variants in DSP have lower skin temperature and higher TEWL, constant microscopic skin involvement with specific patterns and pseudomonilethrix in the trichogram.Andalusian Society of Cardiology with a “beca de Investigación general

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT- 2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the The Catalan Government DURSI grant 2009SGR1489

Adelante / Endavant

Séptimo desafío por la erradicación de la violencia contra las mujeres del Institut Universitari d’Estudis Feministes i de Gènere "Purificación Escribano" de la Universitat Jaume

Preservation of the crude avocado oil with electric field treatment

158-161<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:es;mso-bidi-language:ar-sa"="" lang="EN-US">The effect of an electric field (EF) application on crude avocado oils samples was evaluated and presented. Polyphenol oxidase enzyme in avocado pulp is inactivated by the treatment of EF, the conditions of the treatment are a square voltage 9 kV cm-1 with a <span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa;="" mso-bidi-font-weight:bold"="" lang="EN-US">frequency of 60 Hz for 3 min. The aim of this study was to analyze the effect of the EF as a preservation method on crude avocado oil. EF is<span style="font-size: 11.0pt;mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman","serif";="" mso-fareast-font-family:"times="" roman";mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="" lang="EN-US"> directly applied on avocado pulp and oil was extracted. The oil is stored in a closed container at room temperature and analyzed at different periods of time with the Fourier transform infrared spectroscopy technique in the mid infrared region. Chemical values like acidity, peroxide and iodine are also reported. T<span style="font-size:11.0pt; mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:es-mx;="" mso-bidi-language:ar-sa"="" lang="EN-US">he fatty acid composition in avocado oils is not substantially modified by the EF during the storage. EF treatment may decrease the rate of oxidation reaction of unsaturated fatty acids extending the shelf life of avocado oil.</span

Comparison of the proximal chemical and fatty acid composition of the fried grasshopper’s (Orthoptera) dish

"In Mexico, especially in Hidalgo State, a variety of insects are sold in different culinary preparation ways, which the most accepted by the consumer living in the city are the butter-fried grasshoppers. Therefore, the objective of this work was to compare the proximal chemical composition and the quality of fatty acids in the butter-fried grasshoppers that are commercialized. The samples of fresh and fried grasshoppers were purchased. The fresh samples were dehydrated and both samples were homogenized and proximal chemical composition and fatty acids were analyzed. The oils were extracted with Soxhlet extraction equipment. To measure the quality of the oils, a chemical analysis and an instrumental analysis were carried out. The lipids were the majority in the dehydrated (40.11%) and fried (47.67%) samples. Moisture and temperature were the variables that increased the lipid degradation in the samples. There was a difference in the percentages of saturated and unsaturated fatty acids in dehydrated and fried samples, with 37.11% and 44.41%, and 62.77% and 55.46%, respectively. The excess consumption of this dish, in addition of a low physical activity, can cause damage to the body; therefore, it is suggested to select an alternate lipid source"

Antecedentes familiares de primer grado como factor de riesgo en el cáncer colorrectal

Objective: To evaluate the association between first-degree family history and colorectal cancer (CRC). Method: We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression. Result: First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80-2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29-7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52-6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI: 2.65-8.65). Conclusions: First-degree relatives of CRC increase the chances of developing this tumor, they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures. (C) 2021 SESPAS. Published by Elsevier Espana, S.L.U