LETTER FROM THE EDITOR

We are pleased to publish this special edition of the Journal of Undergraduate Research in Alberta (JURA) which features peer-reviewed abstracts from the 2015 Biomedical Engineering and NSERC CREATE Summer Research Symposium at the University of Calgary. This Symposium allows undergraduate students to gain experience in writing and presenting their summer research projects in a conference-like setting. This year’s Symposium featured four sessions with topics focused around Cell and Tissue Engineering, Imaging, Modelling, Obesity, and Biomechanics.The Research Symposium was jointly supported by the NSERC CREATE Training Program for Biomedical Engineers of the 21st Century and the Biomedical Engineering Graduate Program at the University of Calgary. We would like to start by acknowledging these sponsors for their continued support of the Symposium. Thank you for providing a unique opportunity for enrichment for these young researchers. Special thanks to Dr. Walter Herzog, the founder and leader of the CREATE Program at the University of Calgary. In its final year, the CREATE Training Program funded high-level summer research of another 9 undergraduate researchers. In total, CREATE has funded the work of 57 undergraduate students over the past six years. The program has significantly advanced knowledge in many areas of biomedical engineering research and has given young researchers a head start in their early academic careers. Congratulations to six very successful years. Special thanks to Kenneth Fuh for overseeing the organization of the 2015 Biomedical Engineering and NSERC CREATE Summer Research Symposium and to all members of the CREATE program who contributed to the Research Symposium and this edition of JURA. Lastly, we would like to acknowledge the undergraduate students whose hard work is featured in this special edition of JURA. The Biomedical Engineering and NSERC CREATE Symposium is a success each year because of the efforts put forth by these exceptional students. We hope you enjoy this special edition of JURA.  Sincerely, Maurice Mohr & JURA Editorial Board Editor for the Journal of Undergraduate Research in Albert

Muscle tuning and preferred movement path – a paradigm shift

In the last 40 years, the scientific debate around running injuries and running shoes has been dominated by two paradigms, the ‘impact’ and the ‘pronation’ paradigms. However, the development of running shoe technologies aimed at reducing impact forces and pronation has not led to a decline of running-related injuries. This article recommends to abandon the ‘impact’ and ‘pronation’ paradigms due to a lack of biomechanical and epidemiological evidence and instead suggests a shift to new paradigms: ‘Muscle tuning’ and the ‘preferred movement path’. These paradigms represent new approaches to understanding the biomechanical patterns of each individual runner and how they are controlled by the neuromuscular system. Experimental evidence in support of the ‘muscle tuning’ and ‘preferred movement path’ paradigms are presented and discussed regarding their relevance for running performance, injuries, and footwear. Finally, this paper proposes that the concept of ‘functional groups’ should be used and further developed to overcome the challenge that groups of individuals respond differently to footwear interventions. First, groups of individuals who behave similarly (functional groups) should be identified. Second, running shoes should be selected to match the characteristics of the identified functional groups in order to optimize the beneficial effects of running shoes for improving running performance and reducing the risk of running injuries

EFFECTS OF AN 8-WEEK KNEE INJURY PREVENTION PROGRAM AND TECHNIQUE MODIFICATION TRAINING ON CHANGE-OF-DIRECTION PERFORMANCE

The purpose of this analysis was to determine whether an 8-week knee injury prevention program with an additional focus on change-of-direction (COD) technique training results in improved COD performance compared to a control training group with a focus on linear sprint training. Although both groups showed indicators for superior performance during a 135-degree COD, such as a more effective reorientation of the body, the COD technique modification component was ineffective in improving overall COD completion time or ground contact times. Follow-up analyses will show whether the COD group adopted a safer COD movement strategy following training, e.g. by reducing the knee valgus loading

The preferred movement path paradigm: influence of running shoes on joint movement

PURPOSE: (a) to quantify differences in lower extremity joint kinematics for groups of runners subjected to different running footwear conditions, and (b) to quantify differences in lower extremity joint kinematics on an individual basis for runners subjected to different running footwear conditions. METHODS: Three-dimensional ankle and knee joint kinematics were collected for 35 heel-toe runners when wearing three different running shoes and when running barefoot. Absolute mean differences in ankle and knee joint kinematics were computed between running shoe conditions. The percentage of individual runners who displayed differences below a 2°, 3° and 5° threshold were also calculated. RESULTS: The results indicate that the mean kinematics of the ankle and knee joints were similar between running shoe conditions. Aside from ankle dorsi-flexion and knee flexion, the percentage of runners maintaining their movement path between running shoes (i.e. less than 3°) was in the order of magnitude of about 80 to 100%. Many runners showed ankle and knee joint kinematics that differed between a conventional running shoe and barefoot by more than 3°, especially for ankle dorsiflexion and knee flexion CONCLUSION: Many runners stay in the same movement path (the preferred movement path) when running in various different footwear conditions. The percentage of runners maintaining their preferred movement path depends on the magnitude of the change introduced by the footwear condition

Sex-Specific Hip Movement Is Correlated With Pelvis and Upper Body Rotation During Running

There is a sex bias for common overuse running injuries that are associated with sex-specific hip kinematics. Gait retraining programs aimed at altering hip kinematics may be more efficient if they incorporated an understanding of how hip kinematics are correlated with the movement of the remaining body segments. We applied a principal component analysis to structure the whole-body running kinematics of 23 runners (12 ♀) into k = 12 principal movements (PMk), describing correlated patterns of upper and lower body movements. We compared the time-dependent movement amplitudes with respect to each PMk between males and females using a waveform analysis and interpreted our findings according to stick figure animations. The movement amplitudes of two PMs (PM6 and PM8) showed statistically significant effects of “sex,” which were independent of running speed. According to PM8, females showed more hip adduction, which correlated with increased transverse rotation of the pelvis and upper body compared to men. We propose that increased hip adduction and upper body rotation in female runners may be a strategy to compensate for a less efficient arm and upper body swing compared to men. Gait interventions aimed at reducing hip adduction and running-related injuries in female runners should consider instructions for both upper and lower body to maximize training efficacy

Adolescent brain maturation and cortical folding: evidence for reductions in gyrification

Evidence from anatomical and functional imaging studies have highlighted major modifications of cortical circuits during adolescence. These include reductions of gray matter (GM), increases in the myelination of cortico-cortical connections and changes in the architecture of large-scale cortical networks. It is currently unclear, however, how the ongoing developmental processes impact upon the folding of the cerebral cortex and how changes in gyrification relate to maturation of GM/WM-volume, thickness and surface area. In the current study, we acquired high-resolution (3 Tesla) magnetic resonance imaging (MRI) data from 79 healthy subjects (34 males and 45 females) between the ages of 12 and 23 years and performed whole brain analysis of cortical folding patterns with the gyrification index (GI). In addition to GI-values, we obtained estimates of cortical thickness, surface area, GM and white matter (WM) volume which permitted correlations with changes in gyrification. Our data show pronounced and widespread reductions in GI-values during adolescence in several cortical regions which include precentral, temporal and frontal areas. Decreases in gyrification overlap only partially with changes in the thickness, volume and surface of GM and were characterized overall by a linear developmental trajectory. Our data suggest that the observed reductions in GI-values represent an additional, important modification of the cerebral cortex during late brain maturation which may be related to cognitive development

Dyes, flies, and sunny skies: photodynamic therapy and neglected tropical diseases

Photodynamic therapy, in its various applications, represents the focused combination of electromagnetic radiation, a chemical (usually a dye) capable of its absorption and conversion, and oxygen to provide cytotoxicity (cell killing). The effect has been known for over a century, and there is considerable clinical use in terms of its application to various cancers. However, the antimicrobial properties of the technology, which are considerable, have received only a lukewarm reception by healthcare providers, and the possibilities for tropical disease therapy are mainly unexplored. This is particularly vexatious given both the inexpensive nature of the photosensitisers and light sources available and the lack of conventional forward progress in widespread diseases such as leishmaniasis, trypanosomiasis, and tuberculosis in the Developing World. The following review therefore covers the use, or potential use, of the photodynamic approach in this area, mainly with reference to tropical diseases having current ‘neglected’ status according to the World Health Organisation. © 2016 The Authors. Coloration Technology © 2016 Society of Dyers and Colourist

ECSGS Management Plan

Version 0.9 reviewed by ESA at the Euclid SGS Preliminary Requirements Review (2013) Version 1.9 reviewed by ESA at the Euclid SGS System Requirements Review (2015)The ECSGS Management Plan is focused on the following topics: ECSGS organisation, responsibilities, reporting; ECSGS costing, manpower, effort tracking; ECSGS logistic (when relevant); organisation of individual OUs and SDCs under ECSGS coordination. Sections 9 and 10 contain global and local organisation details, and the names of responsible staff. The management principles expressed in this document are a coherent extension of those described in the ECSGS Science Implementation Plan. The document is compliant with the ECSS standards, as tailored for the Euclid SGS