All the King’s Horses, All the King’s Elephants: The Fates of Royal Animals in Nepal’s Post-Monarchy Period

In May of 2008, Nepal’s 240-year-old monarchy was legally dissolved. In the wake of this dissolution, the new interim government sought to replace royal institutions, procedures, and ceremonies with new, parallel processes. One unexpected royal legacy that politicians needed to resolve was that of the former royal animals that had been connected to the position of the King. The king of Nepal and palace institutions had been responsible for the welfare of a range of animals: private royal horses, a palace dairy herd, elephants in Chitwan, and an aviary of pheasants. Many of Nepal’s ex-royal animals have survived for years after the monarchy’s collapse, and many of them were left vulnerable, with no one clearly responsible for or dedicated to them in the new political context. The peculiar and marginalized fates of Nepal’s ex-royal animals highlight the profound institutional complexity the monarchy once entailed, and the far-reaching consequences of its dissolution. They also reveal the grudging and complex ways that parliamentary politicians and bureaucrats have handled some of the more inconvenient legacies of the institution they eliminated

Nepal and Bhutan in 2014

Both Nepal and Bhutan formed new parliamentary governments in 2014. In both cases, a new party took control, but major policies remained unchanged. Many people experienced hardships in buying basic commodities (because of inflation in Nepal and a subsidy dispute in Bhutan). Nepal faced three natural disasters

The Neurovascular Relation in Oxygen-induced Retinopathy

Purpose: Longitudinal studies in rat models of retinopathy of prematurity (ROP) have demonstrated that abnormalities of retinal vasculature and function change hand-in-hand. In the developing retina, vascular and neural structures are under cooperative molecular control. In this study of rats with oxygen-induced retinopathy (OIR) models of ROP, mRNA expression of vascular endothelial growth factor (VEGF), semaphorin (Sema), and their neuropilin receptor (NRP) were examined during the course of retinopathy to evaluate their roles in the observed neurovascular congruency. Methods: Oxygen exposures designed to induce retinopathy were delivered to Sprague-Dawley rat pups (n=36) from postnatal day (P) 0 to P14 or from P7 to P14. Room-air-reared controls (n=18) were also studied. Sensitivities of the rod photoreceptors ($S_{rod}$) and the postreceptor cells (Sm) were derived from electroretinographic (ERG) records. Arteriolar tortuosity, $T_A$, was derived from digital fundus images using Retinal Image multi-Scale Analysis (RISA) image analysis software. mRNA expression of $VEGF_{164}$, semaphorin IIIA (Sema3A), and neuropilin-1 (NRP-1) was evaluated by RT–PCR of retinal extracts. Tests were performed at P15–P16, P18–P19, and P25–P26. Relations among ERG, RISA, and PCR parameters were evaluated using linear regression on log transformed data. Results: Sm was low and $T_A$ was high at young ages, then both resolved by P25–P26. $VEGF_{164}$ and Sema3A mRNA expression were also elevated early and decreased with age. Low Sm was significantly associated with high $VEGF_{164}$ and Sema3A expression. Low Srod was also significantly associated with high VEGF164. $S_{rod}$ and Sm were both correlated with $T_A$. NRP-1 expression was little affected by OIR. Conclusions: The postreceptor retina appears to mediate the vascular abnormalities that characterize OIR. Because of the relationships revealed by these data, early treatment that targets the neural retina may mitigate the effects of ROP