Síndrome de Klippel -Trenaunay: presentación de un caso clínico

Se presenta una niña de un mes de vida que presentaba una extensa malformación vascular color "vino oporto" en la piel del miembro inferior izquierdo asociada con importante linfedema e hipertrofia corporal segmentaria armónica. Se realizó el diagnóstico de Síndrome de Klippel-Trenaunay, planteándose los diagnósticos diferenciales con Síndrome de Park-Weber, Síndrome de Klippel Trenaunay Servelle y otros.We present a 1-month-old girl with a large vascular malformation in the skin of the left leg associated with lymphedema and segmentary bone hyperthrophy. The diagnosis of Klippel-Trenaunay syndrome was done. We discuss the differential with Park-Weber Syndrome, Klippel Trenaunay Servelle and others

Follow-up of the air pollution and the human male-to-female ratio analysis in São Paulo, Brazil: a times series study

Objectives in order to assess if ambient air pollution in urban areas could be related to alterations in male/female ratio this study objectives to evaluate changes in ambient particulate matter (PM10) concentrations after implementation of pollution control programmes in São Paulo city and the secondary sex ratio (SRR).Design and methods A time series study was conducted. São Paulo's districts were stratified according to the PM10 concentrations levels and were used as a marker of overall air pollution. the male ratio was chosen to represent the secondary sex ratio (SSR=total male birth/total births). the SSR data from each area was analysed according to the time variation and PM10 concentration areas using descriptive statistics. the strength association between annual average of PM10 concentration and SSR was performed through exponential regression, and it was adopted as a statistical significance level of p<0.05.Results the exponential regression showed a negative and significant association between PM10 and SSR. SSR varied from 51.4% to 50.7% in São Paulo in the analysed period (2000-2007). Considering the PM10 average concentration in São Paulo city of 44.72g/m(3) in the study period, the SSR decline reached almost 4.37%, equivalent to 30934 less male births.Conclusions Ambient levels of PM10 are negatively associated with changes in the SSR. Therefore, we can speculate that higher levels of particulate pollution could be related to increased rates of female births.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo UNIFESP, ICAQF, Dept Ciencias Exatas & Terra, São Paulo, BrazilUniv São Paulo, Sch Med, Dept Pathol, Lab Expt Air Pollut LIM05, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, ICAQF, Dept Ciencias Exatas & Terra, São Paulo, BrazilCNPq: 573813/2008-5: FAPESP - 2008/57717-6Web of Scienc

Sickness Presenteeism in the Aftermath of COVID-19: Is Presenteeism Remote-Work Behavior the New (Ab)normal?

Due to the confinement imposed by the COVID-19 pandemic situation, companies adopted remote work more than ever. The rapid rise of remote work also affected local life and many employers introduced or extended their telework activities because of the associated advantages. However, despite the evident positive benefits, some employees were pressured to work remotely while ill. This evidence brought new challenges to the presenteeism literature. This article investigates how individual, economic/societal, and organizational/sectorial/supervisory-related variables can moderate the role of a contagious disease, such as the COVID-19, in explaining presenteeism behavior. Moreover, the current research presents a multi-level conceptual model (i.e., organizational, individual, supervisory factors) to describe how a new construct of remote-work presenteeism behavior mediates the relationship between different post pandemic health conditions (e.g., allergies, back pain, depression, anxiety) and future cumulative negative consequences. The authors suggested that the widespread pervasive adoption of remote work because of COVID-19 has important implications for the presenteeism literature and opens avenues for further research

A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death

: The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one of the factors that contributes to this variability as previously reported by the COVID-19 Host Genetics Initiative (HGI), which identified sixteen loci associated with COVID-19 severity. Herein, we investigated the genetic determinants of COVID-19 mortality, by performing a case-only genome-wide survival analysis, 60 days after infection, of 3904 COVID-19 patients from the GEN-COVID and other European series (EGAS00001005304 study of the COVID-19 HGI). Using imputed genotype data, we carried out a survival analysis using the Cox model adjusted for age, age2, sex, series, time of infection, and the first ten principal components. We observed a genome-wide significant (P-value < 5.0 × 10-8) association of the rs117011822 variant, on chromosome 11, of rs7208524 on chromosome 17, approaching the genome-wide threshold (P-value = 5.19 × 10-8). A total of 113 variants were associated with survival at P-value < 1.0 × 10-5 and most of them regulated the expression of genes involved in immune response (e.g., CD300 and KLR genes), or in lung repair and function (e.g., FGF19 and CDH13). Overall, our results suggest that germline variants may modulate COVID-19 risk of death, possibly through the regulation of gene expression in immune response and lung function pathways

Editorial: Presenteeism in the Aftermath of COVID-19: New Trends and Contributions Regarding Sickness Presence at Work

As Guest Editors for the Frontiers in Psychology (Organizational Psychology section), we are delighted to announce that thirteen thought-provoking articles were accepted for inclusion in this Special Issue entitled 'Presenteeism in the Aftermath of COVID-19: New Trends and Contributions Regarding Sickness Presence at Work'. We believe all these research projects make a substantial contribution to the literature and will set the tone for future avenues of research on sickness presenteeism. In that sense, after a peer review that had the contribution of more than 30 high-quality international external reviewers with expertise in the domain of presenteeism, the 13 accepted papers highlight relevant contributions to the growing field of presenteeism. Undeniably, the COVID-19 pandemic experience has introduced conjunctural and structural challenges in society, economy, organizations, and individuals with determining impact in our life. More than ever, the act of going to work while ill (i.e., presenteeism) has been questioned and, consequently, the construct deserves to be studied in more detail. The therapeutical act of presenteeism (c.f., Karanika-Murray, & Biron, 2020) will never be perceived the way as it was before. Going to work with a contagious disease like the flu, something normal in the past, and sometimes supported by companies with climates (Ferreira et al., 2019) and cultures (Simpson, 1998) of presenteeism, will not likely be observed or even reinforced in the same way. Therefore, this new pandemic imposed some challenges for employees and managers and, as usually, when unexpected events happen, science moves forward. These papers represent just a few examples of how something so relevant such as presenteeism found room for a new era of research. With this collection of articles, we seek to provide some guidance for both managers and employees by helping them to clarify the 'should I stay or should I go to work while ill' dilemma

Editorial Frontiers in Psychology - Special Issue 'Presenteeism in the Aftermath of COVID-19'

As Guest Editors for the Frontiers in Psychology (Organizational Psychology section), we are delighted to announce that thirteen thought-provoking articles were accepted for inclusion in this Special Issue entitled 'Presenteeism in the Aftermath of COVID-19: New Trends and Contributions Regarding Sickness Presence at Work'. We believe all these research projects make a substantial contribution to the literature and will set the tone for future avenues of research on sickness presenteeism. In that sense, after a peer review that had the contribution of more than 30 high-quality international external reviewers with expertise in the domain of presenteeism, the 13 accepted papers highlight relevant contributions to the growing field of presenteeism. Undeniably, the COVID-19 pandemic experience has introduced conjunctural and structural challenges in society, economy, organizations, and individuals with determining impact in our life. More than ever, the act of going to work while ill (i.e., presenteeism) has been questioned and, consequently, the construct deserves to be studied in more detail. The therapeutical act of presenteeism (c.f., Karanika-Murray, & Biron, 2020) will never be perceived the way as it was before. Going to work with a contagious disease like the flu, something normal in the past, and sometimes supported by companies with climates (Ferreira et al., 2019) and cultures (Simpson, 1998) of presenteeism, will not likely be observed or even reinforced in the same way. Therefore, this new pandemic imposed some challenges for employees and managers and, as usually, when unexpected events happen, science moves forward. These papers represent just a few examples of how something so relevant such as presenteeism found room for a new era of research. With this collection of articles, we seek to provide some guidance for both managers and employees by helping them to clarify the 'should I stay or should I go to work while ill' dilemma

Reversible Karatsuba's Algorithm

Karatsuba discovered the first algorithm that accomplishes multiprecision integer multiplication with complexity below that of the grade-school method. This algorithm is implemented nowadays in computer algebra systems using irreversible logic. In this paper we describe reversible circuits for the Karatsuba's algorithm and analyze their computational complexity. We discuss garbage disposal methods and compare with the well known Bennett's schemes. These circuits can be used in reversible computers which have the advantage of being very efficient in terms of energy consumption. The algorithm can also be used in quantum computers and is an improvement of previous circuits for the same purpose described in the literature