Eine Untersuchung kommerzieller Terminverwaltungs-Software im Hinblick auf die Kopplung mit natürlichsprachlichen Systemen

Das Projekt COSMA (Cooperative Schedule Management Agent) verfolgt das Ziel, einen maschinellen Sekretariatsassistenten zu erstellen, der Termine mit mehreren Teilnehmern über elektronische Post in natürlicher Sprache weitgehend selbständig vereinbart. COSMA stellt natürlichsprachlichen Service für autonome maschinelle Terminplanungs-Agenten zur Verfügung. Eine Anbindung an unterschiedliche kommerzielle Softwareprodukte zur Terminverwaltung könnte die Generalisierbarkeit der in COSMA verfolgten Ansätze nachhaltig plausibel machen. In der hier dokumentierten Untersuchung wurden im Zeitraum März bis Mai 1995 auf dem deutschen Markt befindlichen Produkte untersucht und bewertet. Einige ermöglichen den Zugang zu ihren Termindaten über eine allgemeine Programmierschnittstelle; doch keines stellt Agentenfähigkeit zur Verfügung: Alle Planungs-und Entscheidungsvorgänge bleiben dem Benutzer überlassen. Eine Einbindung in COSMA ist in vielen Fällen technisch möglich, aber erst nach Entwicklung und Einbindung geeigneter Agentensysteme sinnvoll.The project COSMA (Cooperative Schedule Management Agent) is developing a machine secretarial assistent, that can autonomously schedule appointments with several participants via electronic mail in natural language. COSMA provides natural language service for autonomous appointment scheduling machine agents. Adaptation of different commercial software products for appointment management could support the claim of generality of the approaches pursued within COSMA. The study described in this document includes products available on the German market between March and May 1995. Some allow access to their appointment data via an application program interface, but no one provides any agent functionality; i.e. all planning and decision making is left to the user. For some systems, adaptation to COSMA is possible technically, but seems meaningful only after developing and adapting suitable agent systems

Edge Couplers with relaxed Alignment Tolerance for Pick-and-Place Hybrid Integration of III-V Lasers with SOI Waveguides

We report on two edge-coupling and power splitting devices for hybrid integration of III-V lasers with sub-micrometric silicon-on-insulator (SOI) waveguides. The proposed devices relax the horizontal alignment tolerances required to achieve high coupling efficiencies and are suitable for passively aligned assembly with pick-and-place tools. Light is coupled to two on-chip single mode SOI waveguides with almost identical power coupling efficiency, but with a varying relative phase accommodating the lateral misalignment between the laser diode and the coupling devices, and is suitable for the implementation of parallel optics transmitters. Experimental characterization with both a lensed fiber and a Fabry-P\'erot semiconductor laser diode has been performed. Excess insertion losses (in addition to the 3 dB splitting) taken as the worst case over both waveguides of respectively 2 dB and 3.1 dB, as well as excellent 1 dB horizontal loss misalignment ranges of respectively 2.8 um and 3.8 um (worst case over both in-plane axes) have been measured for the two devices. Back-reflections to the laser are below -20 dB for both devices within the 1 dB misalignment range. Devices were fabricated with 193 nm DUV optical lithography and are compatible with mass-manufacturing with mainstream CMOS technology

High frequency electro-optic measurement of strained silicon racetrack resonators

The observation of the electro-optic effect in strained silicon waveguides has been considered as a direct manifestation of an induced $\chi^{(2)}$ non-linearity in the material. In this work, we perform high frequency measurements on strained silicon racetrack resonators. Strain is controlled by a mechanical deformation of the waveguide. It is shown that any optical modulation vanishes independently of the applied strain when the applied voltage varies much faster than the carrier effective lifetime, and that the DC modulation is also largely independent of the applied strain. This demonstrates that plasma carrier dispersion is responsible for the observed electro-optic effect. After normalizing out free carrier effects, our results set an upper limit of $8\,pm/V$ to the induced high-speed $\chi^{(2)}_{eff,zzz}$ tensor element at an applied stress of $-0.5\,GPa$. This upper limit is about one order of magnitude lower than the previously reported values for static electro-optic measurements

Design of a high-speed germanium-tin absorption modulator at mid-infrared wavelengths

We propose a high-speed electro-absorption modulator based on a direct bandgap Ge0.875Sn0.125 alloy operating at mid-infrared wavelengths. Enhancement of the Franz-Keldysh-effect by confinement of the applied electric field to GeSn in a reverse-biased junction results in 3.2dB insertion losses, a 35GHz bandwidth and a 6dB extinction ratio for a 2Vpp drive signal

Silicon Nitride C-Band Grating Coupler with Reduced Waveguide Back-Reflection Using Adaptively Corrected Elliptical Grates

We present experimental results for a fully etched C-band grating coupler with reduced back reflection fabricated in an 800 nm silicon nitride platform. Back-reflections are reduced by symmetrically interrupting the first few grates around the center axis of the propagating light. The span of the etched grates is gradually increased until they cover the full width. By interrupting the grates, light is reflected back obliquely, which leads to the excitation of higher-order modes that are scattered out of the structure. While this approach has been previously shown in silicon, it comes with a significant penalty in coupling efficiency of around 2.4 dB of extra loss in the layer stack investigated here. In this work, we present the design and measurement results of a grating coupler in which waveguide-to-waveguide back-reflections are suppressed by ~10 dB with this technique, while at the same time mitigating excess insertion losses by reshaping the grates as ellipses of varying eccentricity. This helps to compensate the phase front error induced by the interruption of the grates. This correction does not affect the level by which the back-reflection is suppressed, but reduces the insertion loss penalty from 2.4 dB to 1 dB

Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis

Antimicrobial resistance represents a growing global health problem. The emergence of novel resistance mechanisms necessitates the development of alternative approaches to investigate the molecular fundamentals of resistance, leading ultimately to new strategies for counteracting them. To gain deeper insight into antibiotic-target interactions, the binding of the frontline anti-tuberculosis drug isoniazid (INH) to a target enzyme, InhA, from Mycobacterium tuberculosis was studied using ultrafast two-dimensional infrared (2D-IR) spectroscopy and molecular simulations. Comparing wild-type InhA with a series of single point mutations, it was found that binding of the INH-NAD inhibitor to susceptible forms of the enzyme caused increased vibrational coupling between residues located in the Rossmann fold co-factor binding site of InhA, reducing dynamic fluctuations. The effect correlated with biochemical assay data, being markedly reduced in the INH-resistant S94A mutant and absent in the biochemically-inactive P193A control. Molecular dynamics simulations and calculations of inter-residue couplings indicate that the changes in coupling and dynamics are not localised to the co-factor binding site, but permeate much of the protein. We thus propose that the resistant S94A mutation circumvents subtle changes in global structural dynamics caused by INH upon binding to the wild-type enzyme that may impact upon the formation of important protein-protein complexes in the fatty acid synthase pathway of M. tuberculosis

Evolutionary distances in the twilight zone -- a rational kernel approach

Phylogenetic tree reconstruction is traditionally based on multiple sequence alignments (MSAs) and heavily depends on the validity of this information bottleneck. With increasing sequence divergence, the quality of MSAs decays quickly. Alignment-free methods, on the other hand, are based on abstract string comparisons and avoid potential alignment problems. However, in general they are not biologically motivated and ignore our knowledge about the evolution of sequences. Thus, it is still a major open question how to define an evolutionary distance metric between divergent sequences that makes use of indel information and known substitution models without the need for a multiple alignment. Here we propose a new evolutionary distance metric to close this gap. It uses finite-state transducers to create a biologically motivated similarity score which models substitutions and indels, and does not depend on a multiple sequence alignment. The sequence similarity score is defined in analogy to pairwise alignments and additionally has the positive semi-definite property. We describe its derivation and show in simulation studies and real-world examples that it is more accurate in reconstructing phylogenies than competing methods. The result is a new and accurate way of determining evolutionary distances in and beyond the twilight zone of sequence alignments that is suitable for large datasets.Comment: to appear in PLoS ON