Sustainable entrepreneurship as a community of practice.

Wilson, Hugh - Associate Supervisor Macdonald, Emma K. Associate SupervisorSustainable entrepreneurship literature at the micro-level of individual enterprises identifies several issues hampering their growth, such as lack of funding and other resources, and psychological and/or geographical isolation. Macro-level research identifies attempts at supportive policy, such as new enterprise funding and incubation hubs; however, sustainable entrepreneurs often find these resources inaccessible or insufficient. There is very limited research, however, examining the impact of the meso-level context of sustainable entrepreneurs, and whether this level can help address their challenges. This study’s motivating objective is therefore: To examine the phenomenon of sustainable entrepreneurship at the meso-level, in order to better understand how it can be enabled. Initial field immersion in an EU-funded research project led abductively to the observation that actors in the sustainable entrepreneurship field appear to interact at the meso-level to address issues collaboratively. This led to the overarching research question: Does a community of practice form around sustainable entrepreneurship, and if so, what does it look like? Three more specific questions were: RQ1: What drives the formation of a sustainable entrepreneurship community of practice? RQ2: What shared practices does the sustainable entrepreneurship community of practice enact? And RQ3: What outcomes arise from these practices, and for whom? These questions were explored through analysis of data-collection episodes over a three-year period that the author attended as a participant observer alongside sustainable entrepreneurs and allied stakeholders. A key finding is that a sustainable-entrepreneurship community of practice exists: actors with a shared commitment to the domain of sustainable entrepreneurship collaborate as part of a community to solve problems by sharing practice and learning from one another. Four drivers for this community of practice are identified: perceived isolation, a lack of resources, reduced government, and prosocial motivation. The community participates in four high-level practices: network building, resource sharing, evolving business models, and re-shaping the sustainable entrepreneurship infrastructure. Four categories of outcome from the community of practice emerge: individual empowerment, enterprise scaling and proliferating, civil society strengthening, and mainstreaming sustainable entrepreneurship. Collectively, these practices can reduce some of the issues facing sustainable entrepreneurs, such as limited funding and resources. This thesis contributes to communities of practice theory by demonstrating that the feature of situated learning (Lave and Wenger, 2011) via the four shared practices creates social capital, highlighted in the entrepreneurship literature as a key factor for success (Honig and Davidsson, 2003). In this way, this thesis provides a novel contribution to theory by indicating how participation in the community of practice can help sustainable entrepreneurs address the issues identified and thereby develop, scale and replicate triple-bottom-line business models. They do so, not just solving problems but supporting the wider multistakeholder members to maximise opportunities and positively influence the societal and political environment for SE. It also shows how situated learning about the domain more widely is both a motivation and desired outcome of CoP membership. Through the social capital generated, this community can influence the macro-level and thereby further mainstream the phenomenon of sustainable entrepreneurship.PhD in Leadership and Managemen

Policy for sustainable entrepreneurship: a crowdsourced framework

Sustainable entrepreneurship—entrepreneurship with social and ecological gains as well as economic ones—has the potential to play a significant role in addressing societal and environmental challenges. However, sustainability and entrepreneurship have hitherto been addressed through separate policy regimes, and it is not clear how policymakers can encourage sustainable entrepreneurship specifically. The authors develop a policy framework for sustainable entrepreneurship, using an open innovation approach with policymakers, business executives, academics, entrepreneurs and other relevant actors, including an online crowdsourcing event with 150 participants. The framework incorporates five policy domains: creating awareness and skills; building networks; funding and investing; measuring impact and performance; and innovating government. The article proposes a modified version of the multi-level perspective (MLP) on how socio-technical transitions occur, since the findings suggest that policy can catalyze the facilitation and aggregation of innovations coming from the niche level, thereby evolving the socio-technical regime, in addition to the role of policy described in earlier work in stabilizing the socio-technical regime. Contributions to entrepreneurship policy literature include the policy domain of measuring impact and performance, as appropriate success measures are non-trivial in a triple bottom line environment, and the potential for open policy innovation in entrepreneurship policy. Contributions to sustainability policy literature include the requirements for support mechanisms and capacity building to empower individuals to contribute as innovators and entrepreneurs and not just consumers. The sustainable entrepreneurship framework can be applied by policymakers to develop context-specific policies: this is illustrated with a worked example of EU policy recommendations. The paper also outlines a method for crowdsourcing policy innovations

Policy for sustainable entrepreneurship: a crowdsourced framework

Sustainable entrepreneurship—entrepreneurship with social and ecological gains as well as economic ones—has the potential to play a significant role in addressing societal and environmental challenges. However, sustainability and entrepreneurship have hitherto been addressed through separate policy regimes, and it is not clear how policymakers can encourage sustainable entrepreneurship specifically. The authors develop a policy framework for sustainable entrepreneurship, using an open innovation approach with policymakers, business executives, academics, entrepreneurs and other relevant actors, including an online crowdsourcing event with 150 participants. The framework incorporates five policy domains: creating awareness and skills; building networks; funding and investing; measuring impact and performance; and innovating government. The article proposes a modified version of the multi-level perspective (MLP) on how socio-technical transitions occur, since the findings suggest that policy can catalyze the facilitation and aggregation of innovations coming from the niche level, thereby evolving the socio-technical regime, in addition to the role of policy described in earlier work in stabilizing the socio-technical regime. Contributions to entrepreneurship policy literature include the policy domain of measuring impact and performance, as appropriate success measures are non-trivial in a triple bottom line environment, and the potential for open policy innovation in entrepreneurship policy. Contributions to sustainability policy literature include the requirements for support mechanisms and capacity building to empower individuals to contribute as innovators and entrepreneurs and not just consumers. The sustainable entrepreneurship framework can be applied by policymakers to develop context-specific policies: this is illustrated with a worked example of EU policy recommendations. The paper also outlines a method for crowdsourcing policy innovations

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival