13 research outputs found

    Slaves for Sale: Abolitionist Art and the American Slave Trade

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    Visual Representations of Slavery Maurie McInnis, an art professor at the University of Virginia has written a rare book. In the first instance she has thrown fresh light on slavery and abolition, two much-studied topics. Secondly, she has produced a book that deserves considerable atte...

    NSTX-U theory, modeling and analysis results

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    The mission of the low aspect ratio spherical tokamak NSTX-U is to advance the physics basis and technical solutions required for optimizing the configuration of next-step steady-state tokamak fusion devices. NSTX-U will ultimately operate at up to 2 MA of plasma current and 1 T toroidal field on axis for 5 s, and has available up to 15 MW of neutral beam injection power at different tangency radii and 6 MW of high harmonic fast wave heating. With these capabilities NSTX-U will develop the physics understanding and control tools to ramp-up and sustain high performance fully non-inductive plasmas with large bootstrap fraction and enhanced confinement enabled via the low aspect ratio, high beta configuration. With its unique capabilities, NSTX-U research also supports ITER and other critical fusion development needs. Super-Alfvenic ions in beam-heated NSTX-U plasmas access energetic particle (EP) parameter space that is relevant for both α-heated conventional and low aspect ratio burning plasmas. NSTX-U can also generate very large target heat fluxes to test conventional and innovative plasma exhaust and plasma facing component solutions. This paper summarizes recent analysis, theory and modelling progress to advance the tokamak physics basis in the areas of macrostability and 3D fields, EP stability and fast ion transport, thermal transport and pedestal structure, boundary and plasma material interaction, RF heating, scenario optimization and real-time control

    The Yersinia Ysc-Yop 'type III' weaponry

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    'Type III secretion'--the mechanism by which some pathogenic bacteria inject proteins straight into the cytosol of eukaryotic cells to 'anaesthetize' or 'enslave' them--was discovered in 1994. Important progress has been made in this area during the past few years: the bacterial organelles responsible for this secretion--called 'injectisomes'--have been visualized, the structures of some of the bacterial protein 'effectors' have been determined, and considerable progress has been made in understanding the intracellular action of the effectors. Type III secretion is key to the pathogenesis of bacteria from the Yersinia genus

    The Virulence Plasmid of Yersinia

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    Size sorting in marine muds: Processes, pitfalls, and prospects for paleoflow-speed proxies

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    The basis for, and use of, fine grain size parameters for inference of paleoflow speeds is reviewed here. The basis resides in data on deposited sediment taken in conjunction with flow speed measurements in the field, experimental data on suspended sediment transport and deposition, and theoretical treatments of the generation of size distributions of deposits from suspension controlled by particle settling velocity and flow speed. In the deep sea, sorting events occur under resuspension/deposition events in benthic storms. At flow speeds below 10 - 15 cm s(-1), size in the noncohesive "sortable silt'' ( 10 - 63 mm) range is controlled by selective deposition, whereas above that range, removal of finer material by winnowing also plays a role. The best particle size instruments to measure a flow speed - related grain size employ the settling velocity method, while laser diffraction sizers can yield misleading results because of particle shape effects. Potential problems, including source effects, downslope supply on continental margins, spatial variability of flow over bedforms, and influence of ice-rafted detritus, are examined. A number of studies using the sortable silt flow speed proxy are reviewed, and inverse modeling of grain size distributions is examined. Outstanding problems are that corroboration is sparse because almost no studies have yet used the full range of proxies for flow rate and water mass identification and that the sortable silt mean size is not yet properly calibrated in terms of flow speed

    The type III secretion injectisome

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    The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver protein effectors across eukaryotic cellular membranes. In recent years, significant progress has been made in our understanding of its structure, assembly and mode of operation. The principal structural components of the injectisome, from the base located in the bacterial cytosol to the tip of the needle protruding from the cell surface, have been investigated in detail. The structures of several constituent proteins were solved at the atomic level and important insights into the assembly process have been gained. However, despite the ongoing concerted efforts of molecular and structural biologists, the role of many of the constituent components of this nanomachine remain unknown
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