15 research outputs found
ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE)
Get PDFBackground: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs
employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to
evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum, a celastraceus, that is used in Mexico
as an anti-infective in febrile-type diseases.
Materials and methods: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested
against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Trypanosoma cruzi. A quantitative HPLC analysis of
pristimerin and tingenone was performed.
Results: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50’s of 0.80,
0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%).
Conclusions: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa
ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE)
No full textBackground: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs
employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to
evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum, a celastraceus, that is used in Mexico
as an anti-infective in febrile-type diseases.
Materials and methods: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested
against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Trypanosoma cruzi. A quantitative HPLC analysis of
pristimerin and tingenone was performed.
Results: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50’s of 0.80,
0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%).
Conclusions: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa
Comparative fingerprint analyses of extracts from the root bark of wild Hippocratea excelsa
No full textIsolation and Identification of Cytotoxic Compounds from Aeschynomene fascicularis, a Mayan Medicinal Plant
No full textSynthesis and biological evaluation of diaryl urea derivatives designed as potential anticarcinoma agents using de novo structure-based lead optimization approach
No full text
Design, synthesis, and biological evaluation of novel benzo[b]thiophene-diaryl urea derivatives as potential anticancer agents
No full textScreening of Venezuelan Medicinal Plant Extracts for Cytostatic and Cytotoxic Activity Against Tumor Cell Lines
No full textNovel anticancer activity and anticancer mechanisms of Brassica oleracea L. var. capitata f. rubra
No full text
