Feature Analysis for Discrimination of Motor Unit Action Potentials

© 2018 IEEE. In electrophysiological signal processing for intramuscular electromyography data (nEMG), single motor unit activity is of great interest. The changes of action potential (MUAP) morphology, motor unit (MU) activation, and recruitment provide the most informative part to study the nature causality in neuromuscular disorders. In practice, for a single nEMG recording, more than one motor unit activities (in the surrounding area of a needle electrode) are usually collected. Such a fact makes the MUAP discrimination that separates single unit activities a crucial task. Most neurology laboratories worldwide still recruit specialists who spend hours to manually or semi-automatically sort MUAPs. From a machine learning perspective, this task is analogous to the clustering-based classification problem in which the number of classes and other class information are unfortunately missing. In this paper, we present a feature analysis strategy to help better utilize unsupervised (i.e., totally automated) methods for MUAP discrimination. To that end, we extract a large pool of features from each MUAP. Then we select the top ranked candidates using clusterability scores as selection criteria. We found spectrograms of wavelet decomposition as a top-ranking feature, highly correlated to the motor unit reference and was more separable than existing features. Using a correlation-based clustering technique, we demonstrate the sorting performance with this feature set. Compared with the reference produced by human experts, our method obtained a comparable result (e.g., equivalent number of classes was found, identical MUAP morphology in each pair of corresponding MU class, and similar histograms of MUs). Taking the manual labels as references, our method got a much higher sensitivity and accuracy than the compared unsupervised sorting method. We obtained a similar result in MUAP classification to the reference

Freezing of Gait Detection in Parkinson's Disease: A Subject-Independent Detector Using Anomaly Scores

© 2012 IEEE. Freezing of gait (FoG) is common in Parkinsonian gait and strongly relates to falls. Current clinical FoG assessments are patients' self-report diaries and experts' manual video analysis. Both are subjective and yield moderate reliability. Existing detection algorithms have been predominantly designed in subject-dependent settings. In this paper, we aim to develop an automated FoG detector for subject independent. After extracting highly relevant features, we apply anomaly detection techniques to detect FoG events. Specifically, feature selection is performed using correlation and clusterability metrics. From a list of 244 feature candidates, 36 candidates were selected using saliency and robustness criteria. We develop an anomaly score detector with adaptive thresholding to identify FoG events. Then, using accuracy metrics, we reduce the feature list to seven candidates. Our novel multichannel freezing index was the most selective across all window sizes, achieving sensitivity (specificity) of 96% (79%). On the other hand, freezing index from the vertical axis was the best choice for a single input, achieving sensitivity (specificity) of 94% (84%) for ankle and 89% (94%) for back sensors. Our subject-independent method is not only significantly more accurate than those previously reported, but also uses a much smaller window (e.g., 3 s versus 7.5 s) and/or lower tolerance (e.g., 0.4 s versus 2 s)

Forensic Investigation of Cyberstalking Cases using Behavioural Evidence Analysis

Behavioural Evidence Analysis (BEA) is, in theory, useful in developing an understanding of the offender, the victim, the crime scene, and the dynamics of the crime. It can add meaning to the evidence obtained through digital forensic techniques and assist investigators with reconstruction of a crime. There is, however, little empirical research examining the application of BEA to actual criminal cases, particularly cyberstalking cases. This study addresses this gap by examining the utility of BEA for such cases in terms of understanding the behavioural and motivational dimensions of offending, and the way in which digital evidence can be interpreted. It reports on the forensic analysis of 20 cyberstalking cases investigated by Dubai Police in the last five years. Results showed that BEA helps to focus an investigation, enables better understanding and interpretation of victim and offender behaviour, and assists in inferring traits of the offender from available digital evidence. These benefits can help investigators to build a stronger case, reduce time wasted to mistakes, and to exclude suspects wrongly accused in cyberstalking cases

Kink oscillations of cooling coronal loops with variable cross-section

We study kink waves and oscillations in a thin expanding magnetic tube in the presence of flow. The tube consists of a core region and a thin transitional region at the tube boundary. In this region the plasma density monotonically decreases from its value in the core region to the value outside the tube. Both the plasma density and velocity of background flow vary along the tube and in time. Using the multiscale expansions we derive the system of two equations describing the kink oscillations. When there is no transitional layer the oscillations are described by the first of these two equations. We use this equation to study the effect of plasma density variation with time on kink oscillations of an expanding tube with a sharp boundary. We assume that the characteristic time of the density variation is much greater than the characteristic time of kink oscillations. Then we use the Wentzel-Kramer-Brillouin (WKB) method to derive the expression for the adiabatic invariant, which is the quantity that is conserved when the plasma density varies. The general theoretical results are applied to the kink oscillations of coronal magnetic loops. We consider an expanding loop with the half-circle shape and assume that the plasma temperature inside a loop decays exponentially with time. We numerically calculated the dependences of the fundamental mode frequency, the ratio of frequencies of the first overtone and fundamental mode, and the oscillation amplitude on time. We obtained that the oscillation frequency and amplitude increase and the frequency ratio decreases due to cooling. The amplitude increase is stronger for loops with a greater expansion factor. This effect is also more pronounced for higher loops. However, it is fairly moderate even for loops that are quite high

Recent Developments of Dual-Band Doherty Power Amplifiers for Upcoming Mobile Communications Systems

Power amplifiers in modern and future communications should be able to handle different modulation standards at different frequency bands, and in addition, to be compatible with the previous generations. This paper reviews the recent design techniques that have been used to operate dual-band amplifiers and in particular the Doherty amplifiers. Special attention is focused on the design methodologies used for power splitters, phase compensation networks, impedance inverter networks and impedance transformer networks of such power amplifier. The most important materials of the dual-band Doherty amplifier are highlighted and surveyed. The main problems and challenges covering dual-band design concepts are presented and discussed. In addition, improvement techniques to enhance such operations are also exploited. The study shows that the transistor parasitic has a great impact in the design of a dual-band amplifier, and reduction of the transforming ratio of the inverter simplifies the dual-band design. The offset line can be functionally replaced by a Π-network in dual-band design rather than T-network

A 70-W Asymmetrical Doherty Power Amplifier for 5G Base Stations

YesMuch attention has been paid to making 5G developments more en-ergy efficient, especially in view of the need for using high data rates with more complex modulation schemes within a limited bandwidth. The concept of the Doherty power amplifier for improving amplifier efficiency is explained in addi-tion to a case study of a 70W asymmetrical Doherty power Amplifier using two GaN HEMTs transistors with peak power ratings of 45W and 25W. The rationale for this choice of power ratio is discussed. The designed circuit works in the 3.4GHz frequency band with 200 MHz bandwidth. Rogers RO4350B substrate with dielectric constant εr=4.66 and thickness 0.035 mm is used. The perfor-mance analysis of the Doherty power amplifier is simulated using AWR MWO software. The simulated results showed that 54-64% drain efficiency has been achieved at 8 dB back-off within the specified bandwidth with an average gain of 10.7 dB

Transcatheter non-contact microwave ablation may enable circumferential renal artery denervation while sparing the vessel intima and media

Aims: Trials of transcatheter renal artery denervation (RDN) have failed to show consistent antihypertensive efficacy. Procedural factors and limitations of radiofrequency ablation can lead to incomplete denervation. The aim of the study was to show that non-contact microwave catheter ablation could produce deep circumferential perivascular heating while avoiding injury to the renal artery intima and media. Methods and results: A novel microwave catheter was designed and tested in a renal artery model consisting of layers of phantom materials embedded with a thermochromic liquid crystal sheet, colour range 50-78°C. Ablations were performed at 140 W for 180 sec and 120 W for 210 sec, delivering 25,200 J with renal arterial flow at 0.5 L/min and 0.1 L/min. Transcatheter microwave ablations 100-160 W for 180 sec were then performed in the renal arteries of five sheep. In vitro, ablations at 140 W and 0.5 L/min flow produced circumferential lesions 5.9±0.2 mm deep and 19.2±1.5 mm long with subendothelial sparing depth of 1.0±0.1 mm. In vivo, transcatheter microwave ablation was feasible with no collateral visceral thermal injury. There was histological evidence of preferential outer media and adventitial ablation. Conclusions: Transcatheter microwave ablation for RDN appears feasible and provides a heating pattern that may enable more complete denervation while sparing the renal arterial intima and media

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

The mitochondrial permeability transition pore is a recognized drug target for neurodegenerative conditions such as multiple sclerosis and for ischemia-reperfusion injury in the brain and heart. The peptidylprolyl isomerase, cyclophilin D (CypD, PPIF), is a positive regulator of the pore, and genetic downregulation or knock-out improves outcomes in disease models. Current inhibitors of peptidylprolyl isomerases show no selectivity between the tightly conserved cyclophilin paralogs and exhibit significant off-target effects, immunosuppression, and toxicity. We therefore designed and synthesized a new mitochondrially targeted CypD inhibitor, JW47, using a quinolinium cation tethered to cyclosporine. X-ray analysis was used to validate the design concept, and biological evaluation revealed selective cellular inhibition of CypD and the permeability transition pore with reduced cellular toxicity compared with cyclosporine. In an experimental autoimmune encephalomyelitis disease model of neurodegeneration in multiple sclerosis, JW47 demonstrated significant protection of axons and improved motor assessments with minimal immunosuppression. These findings suggest that selective CypD inhibition may represent a viable therapeutic strategy for MS and identify quinolinium as a mitochondrial targeting group for <i>in vivo</i> use

Wireless Electromagnetic Radiation Assessment Based on the Specific Absorption Rate (SAR): A Review Case Study

Employing Electromagnetic Fields (EMFs) in new wireless communication and sensing technologies has substantially increased the level of human exposure to EMF waves. This paper presents a useful insight into the interaction of electromagnetic fields with biological media that is defined by the heat generation due to induced currents and dielectric loss. The Specific Absorption Rate (SAR) defines the heating amount in a biological medium that is irradiated by an electromagnetic field value. The paper reviews the radio frequency hazards due to the SAR based on various safety standards and organisations, including a detailed investigation of previously published work in terms of modelling and measurements. It also summarizes the most common techniques utilised between 1978 and 2021, in terms of the operational frequency spectrum, bandwidth, and SAR values