Act Now for Your Tomorrow: Final Report of the National Commission on Nursing Workforce for Long-Term Care

The nursing workforce shortage faced by long-term care providers stems from factors both outside and inside the organization and operation of long-term care services. The nursing shortage diminishes quality of care and increases the costs of providing services. Resolution of the long-term care nursing workforce challenge will require improvement of the recruitment and retention of nurses. The leadership for the efforts to improve the long-term care workforce must come from the community itself. New and sustained leadership for action by long-term care leaders is the critical factor necessary to the development of the recommended initiatives and the achievement of the goals of the National Commission on Nursing Workforce for Long-Term Care

Ion Transport and the True Transference Number in Nonaqueous Polyelectrolyte Solutions for Lithium Ion Batteries.

Nonaqueous polyelectrolyte solutions have been recently proposed as high Li+ transference number electrolytes for lithium ion batteries. However, the atomistic phenomena governing ion diffusion and migration in polyelectrolytes are poorly understood, particularly in nonaqueous solvents. Here, the structural and transport properties of a model polyelectrolyte solution, poly(allyl glycidyl ether-lithium sulfonate) in dimethyl sulfoxide, are studied using all-atom molecular dynamics simulations. We find that the static structural analysis of Li+ ion pairing is insufficient to fully explain the overall conductivity trend, necessitating a dynamic analysis of the diffusion mechanism, in which we observe a shift from largely vehicular transport to more structural diffusion as the Li+ concentration increases. Furthermore, we demonstrate that despite the significantly higher diffusion coefficient of the lithium ion, the negatively charged polyion is responsible for the majority of the solution conductivity at all concentrations, corresponding to Li+ transference numbers much lower than previously estimated experimentally. We quantify the ion-ion correlations unique to polyelectrolyte systems that are responsible for this surprising behavior. These results highlight the need to reconsider the approximations typically made for transport in polyelectrolyte solutions

The Grizzly, April 17, 2008

Owen Gingerich Discusses Religion and Evolution at UC • Breakaway Presents P.S. We\u27ve Missed You at UC! • Kennedy Speaks • Achievement Gap: An Issue Left Behind? • All Dogs Go to Heaven: Review of Black Lab Bistro • UC Theater Dances in an Irish Spring • Opinions: Want Change? Vote Obama; Elitists in Government? Yes Please! • A Swingin\u27 Season for UC Tennishttps://digitalcommons.ursinus.edu/grizzlynews/1762/thumbnail.jp

The Grizzly, November 13, 2008

Berman Expands to Envelop Art and Imagination • Election Night Brings Cheer to Liberal Ursinus College • Changes Expected for This Year\u27s New Member Education • Passage of Prop 8 Leaves Same-Sex Couples Concerned • Days After Election: Obama Gets to Work • Forensics: Not the Science, but the Ursinus Debate Team • Escape Velocity\u27s Eternalmotion Strikes a Chord at UC • Finding the Phillies Parade: An Unforgettable Adventure • History Attached to a Philly Row Home • Opinions: Barack Obama: Our Next President • Kait Sutherland Finishes Out Hockey Reign at Ursinushttps://digitalcommons.ursinus.edu/grizzlynews/1775/thumbnail.jp

The Grizzly, October 9, 2008

Biden and Palin Hold Their Ground in 2008 Debate • Pimps Up, Ho\u27s Down: Hip-Hop Music and Modern Women • Indian Temple Stampede Kills Hundreds, Injures Others • Hollywood Mourns Legend Paul Newman • Earth Shattering Stock Market Fall Shakes Nation • Spotlight on Sally Rousse: Dance Artistry at its Finest • Ursinus in Tuebingen Students Travel to Berlin, Munich • Introducing the Gender Wage Gap • Opinions: Democratic and Republican Extremes at Ursinus College; Zack\u27s Dining: Why Wait? • Women\u27s Rugby in for Incredible Season • UC Men\u27s Rugby: Sport with Quickly Growing Popularityhttps://digitalcommons.ursinus.edu/grizzlynews/1771/thumbnail.jp

The Grizzly, November 20, 2008

Adding Machine Makes Explosive Debut on UC Campus • Active Minds Encourages Students to Relax: Stop Stressing! • Creative Writing Author John Holman Visits UC Students • Is the Economy Affecting Your Waistline? • More Bailout News: AIG • Inside the Busy Life of Senior Laura Ng • Plummer Speaks About Importance of Election • Ottinger Fights Child Illiteracy in Cold • Play n Trade: New Store for Gamers • Letter to the Editor • Sunny Review • Dracula\u27s Ball Recap: Ideal Halloween Destination • Hockey Prepares for On-Campus Nationals This Weekendhttps://digitalcommons.ursinus.edu/grizzlynews/1776/thumbnail.jp

The Grizzly, October 2, 2008

Lighting Up Laws: New Smoking Policies on College Campuses • Sexual Perversity Comes to Ursinus • Water, Water Everywhere • Users to Delete Profiles? Student Reactions to New Facebook • U.S. Credit Crisis Hits Home for Some Ursinus Students • College Students Hurt by Economic Woes • Banned Books Week • Lethal Filler Found in Chinese Dairy • Texting Responsible for Train Crash? • Hispania Dances Their Hearts Out for an Ursinus Audience • Tribute to Sub Connection Employee Patro • A Look Into the Past with the Sophomore Class President • Women in Science: Progress in the Scientific Community • Kabuki Dancer to Choreograph at UC • College Students Targets for ID Theft • Opinions: Presidential Debate 2008: The Battle in Mississippi; Open Your Eyes to the Truth About Senator Barack Obama; Political Messages Overtake Television More Than Ever • Cross Country Senior Spotlight: Christa Johnson • Cosmic Sucker Punch: UC Ultimate Frisbee Scores • Could New Turf Field be the Key to Football\u27s Future Success?https://digitalcommons.ursinus.edu/grizzlynews/1770/thumbnail.jp

A meta-analysis of previous falls and subsequent fracture risk in cohort studies

NC Harvey acknowledges funding from the UK Medical Research Council (MC_PC_21003; MC_PC_21001). The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, and 75N92021D00005. Funding for the MrOS USA study comes from the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128. Funding for the SOF study comes from the National Institute on Aging (NIA), and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supported by grants (AG05407, AR35582, AG05394, AR35584, and AR35583). Funding for the Health ABC study was from the Intramural research program at the National Institute on Aging under the following contract numbers: NO1-AG-6–2101, NO1-AG-6–2103, and NO1-AG-6–2106.Peer reviewedPostprin

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology

Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.

Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity