Depression and cardiovascular disease: Selected findings, controversies, and clinical implications from 2009

We systematically searched published empirical research on depression and cardiovascular disease (CVD) and found 494 unique articles published in 2009. Several particularly notable and provocative findings and controversies emerged from this survey of the 2009 literature. First, multiple large observational studies found that antidepressant use was associated with increased risk of incident stroke, CVD, or sudden cardiac death. Second, four randomized controlled trials on depression interventions in CVD patients reported important efficacy results that should guide future trials. Finally, the vigorous debate on whether patients with CVD should be routinely screened (and subsequently treated) for depression continued in 2009 even as some observed that routine screening for CVD in depressed patients is more evidence-based and appropriate. This article reviews these selected provocative findings and controversies from our search and explores their clinical implications

Men’s and Women’s Health Beliefs Differentially Predict Coronary Heart Disease Incidence in a Population-Based Sample

Objective. To examine gender differences in the association between beliefs in heart disease preventability and 10-year incidence of coronary heart disease (CHD) in a population-based sample. Methods. A total of 2,688 Noninstitutionalized Nova Scotians without prior CHD enrolled in the Nova Scotia Health Study (NSHS95) and were followed for 10 years. Risk factors, health behaviors, and incident CHD were assessed. Participants responded “yes” or “no” to a question about heart disease preventability. Survival models, adjusted for age, income, total and high-density lipoprotein cholesterol, and systolic blood pressure, were used to estimate the relation between health belief and incident CHD. Gender differences in the relation between health beliefs and health behaviors were assessed. Results. Gender was a significant moderator of the relation between belief and CHD incidence; specifically, women who believed heart disease could be prevented were less likely to have incident CHD events compared with women who believed heart disease could not be prevented (hazard ratio [HR] = 0.36, 95% confidence interval [CI] = 0.24-0.55, p < .001). This relation was not found for men. Belief was also related to smoking behavior for women (β = −0.70, odds ratio [OR] = 0.50, 95% CI = 0.33-0.74, p = .001) but not for men. Smoking significantly mediated the relation between health beliefs and incident CHD for women (z = −1.96, p = .05), but not for men. Conclusion. Health belief in prevention and subsequent smoking was an important independent predictor of incident CHD in women but not in men

Separate parts of occipito-temporal white matter fibers are associated with recognition of faces and places

A central finding of functional MRI studies is the highly selective response of distinct brain areas in the occipital temporal cortex to faces and places. However, little is known about the association of white matter fibers with the processing of these object categories. In the current study we used DTI-based tractography to reconstruct two main fibers that connect the occipital lobe with the anterior temporal lobe (inferior longitudinal fasciculus-ILF) and with the frontal lobe (inferior fronto-occipital fasciculus-IFOF) in normal individuals. In addition to MRI scans subjects performed face, scene and body recognition tasks outside the scanner. Results show that recognition of faces and scenes were selectively associated with separate parts of the ILF. In particular, face recognition was highly associated with the fractional anisotropy (FA) of the anterior part of the ILF in the right hemisphere. In contrast, scene recognition was strongly correlated with the FA of the posterior and middle but not the anterior part of the ILF bilaterally. Our findings provide the first demonstration that faces and places are not only associated with distinct brain areas but also with separate parts of white matter fibers

Organizational Studies in Space: Stanislaw Lem and the Writing of Social Science Fiction

This paper seeks to introduce the oeuvre of the Polish science fiction author, Stanislaw Lem, whose work is argued to carry significance for students of organizational conduct. Singling out his most famous novel, Solaris, for particular attention, a critical interpretation is offered that selectively highlights Lem's epistemological and ontological pre-occupations concerning scientific inquiry and the human condition. These concerns are seen to resonate with contemporary issues in the field of organization studies. In particular, the rhetorical role of mimesis, viewed as a synthesis of rational and non-rational human motives, within Solaris is taken to inform a wide range of human conduct. The paper concludes by calling for a realist mode of organizational discourse that explores the dialectical relationship between what it characterizes as 'solar' and 'lunar' dimensions of human behaviour. A new challenge to organization studies will be not simply to learn from the substantive concerns of literary genres such as science fiction, but also to aspire after the narrative skills of their leading exponents

Detailed analysis of the isotopic composition of CO and characterization of the air masses arriving at Mount Sonnblick (Austrian Alps)

Air sampling for analysis of CO and its isotopic composition (C-13, O-18, and C-14) has been performed at the alpine station Sonnblick(47 degreesN, 13 degreesE, 3106 m above sea level) since September 1996. A high degree of variability is observed, which is due to the wide variation in the origin of air masses sampled. On the basis of the CO and isotope results, a classification of the different samples is performed. Other data such as Be-7, O-3, relative humidity, and back trajectories are used to give additional information about the air mass origin. Background values, representative of the NH midlatitudes free troposphere, are observed about 50% of the time and are used to define seasonal cycles. CO and its isotopes show a minimum in summer and a maximum in winter with extreme values of 90 and 160 ppb for CO, -30 and -25 parts per thousand for delta C-13, 0 and 8 parts per thousand for delta O-18, and 8 and 20 molecules cm(-3) STP for (CO)-C-14. CO and stable isotope data are compared with results from a three-dimensional model (TM2). Generally good agreement supports the CO, delta (CO)-C-13, and deltaC(18)O source/sink distributions inferred by the model. According to model calculations, fossil fuel combustion contributes 35% in summer and 50% in winter of total CO for such a midlatitude location. Other categories of sampled air are "subtropical," "polluted," and "stratospheric" and are observed 24%, 18%, and 4% of the time. Corresponding signatures of CO and its isotopic variations are presented, and some specific events are discussed